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Index > Protein center > CTCFL(Gene name) > Human
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  • CTCFL (Gene name),
  • Transcriptional repressor CTCFL (Protein name ),  CTCFL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CTCFL(BORIS);
    Protein name:
    Transcriptional repressor CTCFL;
    Alternative:
    CCCTC-binding factor;Brother of the regulator of imprinted sites;CTCF-like protein;CTCF paralog;Zinc finger protein CTCF-T;Cancer/testis antigen 27(CT27);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3.
    Function:
    Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    663
    Sequence:
    50:
    MAATEISVLS | EQFTKIKELE | LMPEKGLKEE | EKDGVCREKD | HRSPSELEAE | 
    100:
    RTSGAFQDSV | LEEEVELVLA | PSEESEKYIL | TLQTVHFTSE | AVELQDMSLL | 
    150:
    SIQQQEGVQV | VVQQPGPGLL | WLEEGPRQSL | QQCVAISIQQ | ELYSPQEMEV | 
    200:
    LQFHALEENV | MVASEDSKLA | VSLAETTGLI | KLEEEQEKNQ | LLAERTKEQL | 
    250:
    FFVETMSGDE | RSDEIVLTVS | NSNVEEQEDQ | PTAGQADAEK | AKSTKNQRKT | 
    300:
    KGAKGTFHCD | VCMFTSSRMS | SFNRHMKTHT | SEKPHLCHLC | LKTFRTVTLL | 
    350:
    RNHVNTHTGT | RPYKCNDCNM | AFVTSGELVR | HRRYKHTHEK | PFKCSMCKYA | 
    400:
    SVEASKLKRH | VRSHTGERPF | QCCQCSYASR | DTYKLKRHMR | THSGEKPYEC | 
    450:
    HICHTRFTQS | GTMKIHILQK | HGENVPKYQC | PHCATIIARK | SDLRVHMRNL | 
    500:
    HAYSAAELKC | RYCSAVFHER | YALIQHQKTH | KNEKRFKCKH | CSYACKQERH | 
    550:
    MTAHIRTHTG | EKPFTCLSCN | KCFRQKQLLN | AHFRKYHDAN | FIPTVYKCSK | 
    600:
    CGKGFSRWIN | LHRHSEKCGS | GEAKSAASGK | GRRTRKRKQT | ILKEATKGQK | 
    650:
    EAAKGWKEAA | NGDEAAAEEA | STTKGEQFPG | EMFPVACRET | TARVKEEVDE | 
    663:
    GVTCEMLLNT | MDK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Transcriptional repressor CTCFL
    Cat.:
    E2613h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Transcriptional repressor CTCFL
    Cat.:
    E2613m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Transcriptional repressor CTCFL
    Cat.:
    U2613m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Transcriptional repressor CTCFL
    Cat.:
    U2613h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Transcriptional repressor CTCFL
    Cat.:
    P2613Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Transcriptional repressor CTCFL
    Cat.:
    P2613Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Transcriptional repressor CTCFL
    Monoclonal Antibody for Human Transcriptional repressor CTCFL
    Protein for Human Transcriptional repressor CTCFL
    Protein for Human Transcriptional repressor CTCFL

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma."
      Loukinov D.I. , Pugacheva E. , Vatolin S. , Pack S.D. , Moon H. , Chernukhin I. , Mannan P. , Larsson E. , Kanduri C. , Vostrov A.A. , Cui H. , Niemitz E.L. , Rasko J.E.J. , Docquier F.M. , Kistler M. , Breen J.J. , Zhuang Z. , Quitschke W.W. , more...
      Proc. Natl. Acad. Sci. U.S.A.99:6806-6811(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10 AND 11);FUNCTION;VARIANT ALA-177
      tissue: Testis.
    2. 2.
      "The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation."
      Jelinic P. , Stehle J.-C. , Shaw P.
      PLoS Biol.4:E355-E355(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Testis.
    3. 3.
      "Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors."
      Renaud S. , Pugacheva E.M. , Delgado M.D. , Braunschweig R. , Abdullaev Z. , Loukinov D. , Benhattar J. , Lobanenkov V.
      Nucleic Acids Res.35:7372-7388(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-177
      tissue: Testis.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-177
      tissue: Testis.
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-177
    8. 8.
      "The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer."
      Klenova E.M. , Morse H.C. III , Ohlsson R. , Lobanenkov V.V.
      Semin. Cancer Biol.12:399-414(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    9. 9.
      "DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation."
      Sun L. , Huang L. , Nguyen P. , Bisht K.S. , Bar-Sela G. , Ho A.S. , Bradbury C.M. , Yu W. , Cui H. , Lee S. , Trepel J.B. , Feinberg A.P. , Gius D.
      Cancer Res.68:2726-2735(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression."
      Nguyen P. , Bar-Sela G. , Sun L. , Bisht K.S. , Cui H. , Kohn E. , Feinberg A.P. , Gius D.
      Mol. Cell. Biol.28:6720-6729(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BAG6/BAT3 AND SETD1A
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