Gene name:
CX3CR1 (CMKBRL1;GPR13) ;
Protein name:
CX3C chemokine receptor 1 (C-X3-C CKR-1;CX3CR1) ;
Alternative:
CMK-BRL-1 (CMK-BRL1) ;Beta chemokine receptor-like 1 ;G-protein coupled receptor 13 ;Fractalkine receptor ;V28 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160.
Function:
Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MDQFPESVTE | NFEYDDLAEA | CYIGDIVVFG | TVFLSIFYSV | IFAIGLVGNL |
100:
LVVFALTNSK | KPKSVTDIYL | LNLALSDLLF | VATLPFWTHY | LINEKGLHNA |
150:
MCKFTTAFFF | IGFFGSIFFI | TVISIDRYLA | IVLAANSMNN | RTVQHGVTIS |
200:
LGVWAAAILV | AAPQFMFTKQ | KENECLGDYP | EVLQEIWPVL | RNVETNFLGF |
250:
LLPLLIMSYC | YFRIIQTLFS | CKNHKKAKAI | KLILLVVIVF | FLFWTPYNVM |
300:
IFLETLKLYD | FFPSCDMRKD | LRLALSVTET | VAFSHCCLNP | LIYAFAGEKF |
350:
RRYLYHLYGK | CLAVLCGRSV | HVDFSSSESQ | RSRHGSVLSS | NFTYHTSDGD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
Rabbit
ELISA Kit for Human C-X3-C CKR-1
ELISA Kit for Human C-X3-C CKR-1
ELISA Kit for Human C-X3-C CKR-1
ELISA Kit for Human C-X3-C CKR-1
ELISA Kit for Human C-X3-C CKR-1
CLIA Kit for Human C-X3-C CKR-1
CLIA Kit for Human C-X3-C CKR-1
CLIA Kit for Human C-X3-C CKR-1
CLIA Kit for Human C-X3-C CKR-1
CLIA Kit for Human C-X3-C CKR-1
Polyclonal Antibody for Human C-X3-C CKR-1
Polyclonal Antibody for Human C-X3-C CKR-1
Polyclonal Antibody for Human C-X3-C CKR-1
Polyclonal Antibody for Human C-X3-C CKR-1
Polyclonal Antibody for Human C-X3-C CKR-1
Monoclonal Antibody for Human C-X3-C CKR-1
Monoclonal Antibody for Human C-X3-C CKR-1
Monoclonal Antibody for Human C-X3-C CKR-1
Monoclonal Antibody for Human C-X3-C CKR-1
Monoclonal Antibody for Human C-X3-C CKR-1
Protein for Human C-X3-C CKR-1
Protein for Human C-X3-C CKR-1
Protein for Human C-X3-C CKR-1
Protein for Human C-X3-C CKR-1
Protein for Human C-X3-C CKR-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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Nat. Genet.36:40-45(2004)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-185 (ISOFORM 4);VARIANTS ILE-249 AND MET-280
tissue :
Amygdala .
tissue :
Thalamus .
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Submitted (2006-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASP-13; ILE-249 AND MET-280
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Blood .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HRSV PROTEIN G
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING;CHARACTERIZATION (ISOFORMS 2 AND 3)
12.
"Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion."
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Cell91:521-530(1997)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
14.
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Autran B.
,
Delfraissy J.-F.
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Science287:2274-2277(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS ALA-57; ILE-122; ILE-249 AND MET-280
15.
"Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease."
Moatti D.
,
Faure S.
,
Fumeron F.
,
Amara M.E.-W.
,
Seknadji P.
,
McDermott D.H.
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de Prost D.
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Blood97:1925-1928(2001)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT ILE-249
16.
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Cited for : VARIANTS ILE-249 AND MET-280;ASSOCIATION WITH ARMD12
17.
"CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration."
Combadiere C.
,
Feumi C.
,
Raoul W.
,
Keller N.
,
Rodero M.
,
Pezard A.
,
Lavalette S.
,
Houssier M.
,
Jonet L.
,
Picard E.
,
Debre P.
,
Sirinyan M.
,
Deterre P.
,
Ferroukhi T.
,
Cohen S.Y.
,
Chauvaud D.
,
Jeanny J.C.
,
Chemtob S.
,
Behar-Cohen F.
,
Sennlaub F.
more...
J. Clin. Invest.117:2920-2928(2007)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : CHARACTERIZATION OF VARIANTS ILE-249 AND MET-280;EFFECT ON CHEMOTAXIS OF MONOCYTES OF ARMD12 PATIENTS