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Index > Protein center > CX3CR1(Gene name) > Human
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  • CX3CR1 (Gene name),
  • CX3C chemokine receptor 1 (Protein name ),  CX3C1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CX3CR1(CMKBRL1;GPR13);
    Protein name:
    CX3C chemokine receptor 1(C-X3-C CKR-1;CX3CR1);
    Alternative:
    CMK-BRL-1(CMK-BRL1);Beta chemokine receptor-like 1;G-protein coupled receptor 13;Fractalkine receptor;V28;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160.
    Function:
    Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    355
    Sequence:
    50:
    MDQFPESVTE | NFEYDDLAEA | CYIGDIVVFG | TVFLSIFYSV | IFAIGLVGNL | 
    100:
    LVVFALTNSK | KPKSVTDIYL | LNLALSDLLF | VATLPFWTHY | LINEKGLHNA | 
    150:
    MCKFTTAFFF | IGFFGSIFFI | TVISIDRYLA | IVLAANSMNN | RTVQHGVTIS | 
    200:
    LGVWAAAILV | AAPQFMFTKQ | KENECLGDYP | EVLQEIWPVL | RNVETNFLGF | 
    250:
    LLPLLIMSYC | YFRIIQTLFS | CKNHKKAKAI | KLILLVVIVF | FLFWTPYNVM | 
    300:
    IFLETLKLYD | FFPSCDMRKD | LRLALSVTET | VAFSHCCLNP | LIYAFAGEKF | 
    350:
    RRYLYHLYGK | CLAVLCGRSV | HVDFSSSESQ | RSRHGSVLSS | NFTYHTSDGD | 
    355:
    ALLLL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human C-X3-C CKR-1
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    E1523r
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    ELISA Kit for Human C-X3-C CKR-1
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    E1523h
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    ELISA Kit for Human C-X3-C CKR-1
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    ELISA Kit for Human C-X3-C CKR-1
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    E1523b
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    Packing:
    96T
    ELISA Kit for Human C-X3-C CKR-1
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    CLIA Kit for Human C-X3-C CKR-1
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    U1523b
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    CLIA Kit for Human C-X3-C CKR-1
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    U1523h
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    Packing:
    96T
    CLIA Kit for Human C-X3-C CKR-1
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    CLIA Kit for Human C-X3-C CKR-1
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    Packing:
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    CLIA Kit for Human C-X3-C CKR-1
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    Packing:
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    Polyclonal Antibody for Human C-X3-C CKR-1
    Polyclonal Antibody for Human C-X3-C CKR-1
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    P1523Rb-m
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    Packing:
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    Polyclonal Antibody for Human C-X3-C CKR-1
    Polyclonal Antibody for Human C-X3-C CKR-1
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    P1523Rb-r
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    Polyclonal Antibody for Human C-X3-C CKR-1
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    P1523Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human C-X3-C CKR-1
    Monoclonal Antibody for Human C-X3-C CKR-1
    Monoclonal Antibody for Human C-X3-C CKR-1
    Monoclonal Antibody for Human C-X3-C CKR-1
    Monoclonal Antibody for Human C-X3-C CKR-1
    Protein for Human C-X3-C CKR-1
    Protein for Human C-X3-C CKR-1
    Protein for Human C-X3-C CKR-1
    Protein for Human C-X3-C CKR-1
    Protein for Human C-X3-C CKR-1

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    References
    1. 1.
      "The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues."
      Raport C.J. , Schweickart V.L. , Eddy R.L. Jr. , Shows T.B. , Gray P.W.
      Gene163:295-299(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene."
      Combadiere C. , Ahuja S.K. , Murphy P.M.
      DNA Cell Biol.14:673-680(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus."
      DeVries M.E. , Cao H. , Wang J. , Xu L. , Kelvin A.A. , Ran L. , Chau L.A. , Madrenas J. , Hegele R.A. , Kelvin D.J.
      J. Biol. Chem.278:11985-11994(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-185 (ISOFORM 4);VARIANTS ILE-249 AND MET-280
      tissue: Amygdala.
      tissue: Thalamus.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      NIEHS SNPs program
      Submitted (2007-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASP-13; ILE-249 AND MET-280
    7. 7.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Blood.
    10. 10.
      "CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein."
      Tripp R.A. , Jones L.P. , Haynes L.M. , Zheng H. , Murphy P.M. , Anderson L.J.
      Nat. Immunol.2:732-738(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HRSV PROTEIN G
    11. 11.
      "Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors."
      Garin A. , Tarantino N. , Faure S. , Daoudi M. , Lecureuil C. , Bourdais A. , Debre P. , Deterre P. , Combadiere C.
      J. Immunol.171:5305-5312(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;CHARACTERIZATION (ISOFORMS 2 AND 3)
    12. 12.
      "Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion."
      Imai T. , Hieshima K. , Haskell C. , Baba M. , Nagira M. , Nishimura M. , Kakizaki M. , Takagi S. , Nomiyama H. , Schall T.J. , Yoshie O.
      Cell91:521-530(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    13. 13.
      "Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1."
      Combadiere C. , Salzwedel K. , Smith E.D. , Tiffany H.L. , Berger E.A. , Murphy P.M.
      J. Biol. Chem.273:23799-23804(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    14. 14.
      "Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1."
      Faure S. , Meyer L. , Costagliola D. , Vaneensberghe C. , Genin E. , Autran B. , Delfraissy J.-F. , McDermott D.H. , Murphy P.M. , Debre P. , Theodorou I. , Combadiere C.
      Science287:2274-2277(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-57; ILE-122; ILE-249 AND MET-280
    15. 15.
      "Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease."
      Moatti D. , Faure S. , Fumeron F. , Amara M.E.-W. , Seknadji P. , McDermott D.H. , Debre P. , Aumont M.C. , Murphy P.M. , de Prost D. , Combadiere C.
      Blood97:1925-1928(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-249
    16. 16.
      "The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration."
      Tuo J. , Smith B.C. , Bojanowski C.M. , Meleth A.D. , Gery I. , Csaky K.G. , Chew E.Y. , Chan C.C.
      FASEB J.18:1297-1299(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-249 AND MET-280;ASSOCIATION WITH ARMD12
    17. 17.
      "CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration."
      Combadiere C. , Feumi C. , Raoul W. , Keller N. , Rodero M. , Pezard A. , Lavalette S. , Houssier M. , Jonet L. , Picard E. , Debre P. , Sirinyan M. , Deterre P. , Ferroukhi T. , Cohen S.Y. , Chauvaud D. , Jeanny J.C. , Chemtob S. , more...
      J. Clin. Invest.117:2920-2928(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS ILE-249 AND MET-280;EFFECT ON CHEMOTAXIS OF MONOCYTES OF ARMD12 PATIENTS
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