CXCR4 ELISA Kit for Human(Homo sapiens) | EIAab.comCXCR4 ELISA Kit for Human(Homo sapiens)

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CXCR4 (Gene name),

C-X-C chemokine receptor type 4 (Protein name ), CXCR4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

CXCR4;

Protein name:

C-X-C chemokine receptor type 4(CXC-R4;CXCR-4);

Alternative:

Fusin;FB22;LCR1;HM89;NPYRL;Leukocyte-derived seven transmembrane domain receptor(LESTR);Stromal cell-derived factor 1 receptor(SDF-1 receptor);

CD:

CD184;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin.

Function:

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.

Subcellular Location:

Cell membrane Multi-pass membrane protein In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated.

Protein Attributes:

Sequence length:

352

Sequence:

50:

100:

150:

200:

250:

300:

350:

352:

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

String:

P61073

MIM:

162643

Pfam:

PF00001

STRING:

9606.ENSP00000386884

UniGene:

Hs.593413

KEGG:

hsa:7852

SMR:

P61073

Uniprot:

P61073

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ELISA Kit for Human CXC-R4

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E2170h

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ELISA Kit for Human CXC-R4

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E2170p

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96T

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ELISA Kit for Human CXC-R4

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E2170b

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ELISA Kit for Human CXC-R4

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E2170m

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ELISA Kit for Human CXC-R4

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E2170d

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96T

ELISA Kit for Human CXC-R4

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E2170r

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96T

CLIA Kit for Human CXC-R4

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U2170p

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96T

CLIA Kit for Human CXC-R4

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U2170b

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96T

CLIA Kit for Human CXC-R4

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U2170m

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96T

CLIA Kit for Human CXC-R4

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U2170h

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CLIA Kit for Human CXC-R4

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U2170r

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CLIA Kit for Human CXC-R4

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U2170d

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Polyclonal Antibody for Human CXC-R4

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P2170Rb-r

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Polyclonal Antibody for Human CXC-R4

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P2170Rb-h

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Polyclonal Antibody for Human CXC-R4

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P2170Rb-m

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Monoclonal Antibody for Human CXC-R4

Protein for Human CXC-R4

R&D Technical Data

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Precision

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Citations

[1].

"The serum concentrations of chemokine CXCL12 and its specific receptor CXCR4 in patients with esophageal cancer"

M Łukaszewicz-Zając, B Mroczko, M Kozłowski, et al.

From:Disease markers

References

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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PRELIMINARY FUNCTION
tissue: Lung.
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"A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells."
Jazin E.E. , Yoo H. , Blomqvist A.G. , Yee F. , Weng G. , Walker M.W. , Salon J. , Larhammar D. , Wahlestedt C.R.
Regul. Pept.47:247-258(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PRELIMINARY FUNCTION
tissue: Fetal brain.
3.

"Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen."
Federsppiel B. , Melhado I.G. , Duncan A.M.V. , Delaney A.D. , Schappert K. , Clark-Lewis I. , Jirik F.R.
Genomics16:707-712(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal spleen.
4.

"Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes."
Loetscher M. , Geiser T. , O'Reilly T. , Zwahlen R. , Baggiolini M. , Moser B.
J. Biol. Chem.269:232-237(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Monocyte.
5.

"Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors."
Nomura H. , Nielsen B.W. , Matsushima K.
Int. Immunol.5:1239-1249(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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"HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor."
Feng Y. , Broder C.C. , Kennedy P.E. , Berger E.A.
Science272:872-877(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION OF ITS HIV-1 CORECEPTOR FUNCTION
7.

"Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1."
Wegner S.A. , Ehrenberg P.K. , Chang G. , Dayhoff D.E. , Sleeker A.L. , Michael N.L.
J. Biol. Chem.273:4754-4760(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Peripheral blood leukocyte.
8.

"Genomic organization and promoter characterization of human CXCR4 gene."
Caruz A. , Samsom M. , Alonso J.M. , Alcami J. , Baleux F. , Virelizier J.-L. , Parmentier M. , Arenzana-Seisdedos F.
FEBS Lett.426:271-278(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
9.

"Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion."
Xiao L. , Weiss S.H. , Qari S.H. , Rudolph D. , Zhao C. , Denny T.N. , Hodge T. , Lal R.B.
AIDS Res. Hum. Retroviruses15:1201-1208(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
10.

"Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues."
Frodl R. , Gierschik P. , Moepps B.
J. Recept. Signal Transduct.18:321-344(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Peripheral blood lymphocyte.
11.

"CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant."
Gupta S.K. , Pillarisetti K.
J. Immunol.163:2368-2372(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Neutrophil.
12.

Fan Z. , Li T. , Li J. , Luo B.
Submitted (2001-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
13.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Adrenal gland.
14.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Warren C.N. , Aronstam R.S. , Sharma S.V.
Submitted (2003-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
15.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
16.

SeattleSNPs variation discovery resource
Submitted (2004-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
17.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
18.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
19.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon.
20.

"The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry."
Bleul C.C. , Farzan M. , Choe H. , Parolin C. , Clark-Lewis I. , Sodroski J. , Springer T.A.
Nature382:829-833(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
21.

"The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1."
Oberlin E. , Amara A. , Bachelerie F. , Bessia C. , Virelizier J.-L. , Arenzana-Seisdedos F. , Schwartz O. , Heard J.-M. , Clark-Lewis I. , Legler D.F. , Loetscher M. , Baggiolini M. , Moser B.
Nature382:833-835(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
22.

Oberlin E. , Amara A. , Bachelerie F. , Bessia C. , Virelizier J.-L. , Arenzana-Seisdedos F. , Schwartz O. , Heard J.-M. , Clark-Lewis I. , Legler D.F. , Loetscher M. , Baggiolini M. , Moser B.
Nature384:288-288(1996)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
23.

"Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines."
Lapham C.K. , Ouyang J. , Chandrasekhar B. , Nguyen N.Y. , Dimitrov D.S. , Golding H.
Science274:602-605(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION AS HIV-1 CORECEPTOR
24.

"CD4-independent infection by HIV-2 is mediated by fusin/CXCR4."
Endres M.J. , Clapham P.R. , Marsh M. , Ahuja M. , Turner J.D. , McKnight A. , Thomas J.F. , Stoebenau-Haggarty B. , Choe S. , Vance P.J. , Wells T.N.C. , Power C.A. , Sutterwala S.S. , Doms R.W. , Landau N.R. , Hoxie J.A.
Cell87:745-756(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION AS HIV-2 PRIMARY RECEPTOR IN SOME ISOLATES
25.

"AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor."
Donzella G.A. , Schols D. , Lin S.W. , Este J.A. , Nagashima K.A. , Maddon P.J. , Allaway G.P. , Sakmar T.P. , Henson G. , De Clercq E. , Moore J.P.
Nat. Med.4:72-77(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ANTAGONIST;INTERACTION WITH CXCL12;CHARACTERIZATION AS HIV-1 CORECEPTOR
26.

"Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry."
Farzan M. , Mirzabekov T. , Kolchinsky P. , Wyatt R. , Cayabyab M. , Gerard N.P. , Gerard C. , Sodroski J. , Choe H.
Cell96:667-676(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION
27.

"Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses."
Brelot A. , Heveker N. , Adema K. , Hosie M.J. , Willett B. , Alizon M.
J. Virol.73:2576-2586(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ARG-183; ARG-188 AND ASP-193
28.

"Identification of CXCR4 domains that support coreceptor and chemokine receptor functions."
Doranz B.J. , Orsini M.J. , Turner J.D. , Hoffman T.L. , Berson J.F. , Hoxie J.A. , Peiper S.C. , Brass L.F. , Doms R.W.
J. Virol.73:2752-2761(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAINS;INTERACTION WITH HIV-1 SURFACE PROTEIN GP120
29.

"beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4."
Cheng Z.J. , Zhao J. , Sun Y. , Hu W. , Wu Y.L. , Cen B. , Wu G.-X. , Pei G.
J. Biol. Chem.275:2479-2485(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2;FUNCTION
30.

"Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities."
Brelot A. , Heveker N. , Montes M. , Alizon M.
J. Biol. Chem.275:23736-23744(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CXCL12;MUTAGENESIS OF 2-GLU--SER-9; 4-ILE--ASP-20; TYR-7; 10-ASP--ASP-20; TYR-12; 14-GLU-GLU-15; TYR-21; ASP-97; ASP-171; ASP-187; ASP-193; ASP-262; GLU-268 AND GLU-288
31.

"N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates."
Chabot D.J. , Chen H. , Dimitrov D.S. , Broder C.C.
J. Virol.74:4404-4413(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-11;INTERACTION WITH HIV-1 ENV;SUBUNIT;MUTAGENESIS OF ASN-11; THR-13 AND ASN-176
32.

"Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1."
Xiao H. , Neuveut C. , Tiffany H.L. , Benkirane M. , Rich E.A. , Murphy P.M. , Jeang K.-T.
Proc. Natl. Acad. Sci. U.S.A.97:11466-11471(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT
33.

"A CD14-independent LPS receptor cluster."
Triantafilou K. , Triantafilou M. , Dedrick R.L.
Nat. Immunol.2:338-345(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION AS LPS RECEPTOR;INTERACTION WITH GDF5; HSP90AA1 AND HSPA8;TISSUE SPECIFICITY
34.

"The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry."
Farzan M. , Babcock G.J. , Vasilieva N. , Wright P.L. , Kiprilov E. , Mirzabekov T. , Choe H.
J. Biol. Chem.277:29484-29489(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-18;IDENTIFICATION OF PROTEOGLYCAN;INTERACTION WITH CXCL12;SULFATION AT TYR-21;MUTAGENESIS OF TYR-7; THR-8; SER-9; TYR-12; SER-18 AND TYR-21
35.

"The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4."
Marchese A. , Raiborg C. , Santini F. , Keen J.H. , Stenmark H. , Benovic J.L.
Dev. Cell5:709-722(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY ITCH;SUBCELLULAR LOCATION
36.

"Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease."
Hernandez P.A. , Gorlin R.J. , Lukens J.N. , Taniuchi S. , Bohinjec J. , Francois F. , Klotman M.E. , Diaz G.A.
Nat. Genet.34:70-74(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
37.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
38.

"Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells."
Forde S. , Tye B.J. , Newey S.E. , Roubelakis M. , Smythe J. , McGuckin C.P. , Pettengell R. , Watt S.M.
Blood109:1825-1833(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD164
39.

"Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation."
Berchiche Y.A. , Chow K.Y. , Lagane B. , Leduc M. , Percherancier Y. , Fujii N. , Tamamura H. , Bachelerie F. , Heveker N.
J. Biol. Chem.282:5111-5115(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASN-119; ASP-133; ARG-134 AND TYR-135
40.

"Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases."
Seibert C. , Veldkamp C.T. , Peterson F.C. , Chait B.T. , Volkman B.F. , Sakmar T.P.
Biochemistry47:11251-11262(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION AT TYR-7; TYR-12 AND TYR-21;INTERACTION WITH CXCL12
41.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
42.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319 AND SER-348;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
43.

"The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction."
Bhandari D. , Robia S.L. , Marchese A.
Mol. Biol. Cell20:1324-1339(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITCH;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-324 AND SER-325;MUTAGENESIS OF SER-324; SER-325 AND SER-330
44.

"Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling."
Busillo J.M. , Armando S. , Sengupta R. , Meucci O. , Bouvier M. , Benovic J.L.
J. Biol. Chem.285:7805-7817(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-321; SER-324; SER-325; SER-330; SER-339 AND SER-351;INTERACTION WITH ARRB2 AND ARRC;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY
45.

"CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin."
Saini V. , Marchese A. , Majetschak M.
J. Biol. Chem.285:15566-15576(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBIQUITIN
46.

"F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse."
Perez-Martinez M. , Gordon-Alonso M. , Cabrero J.R. , Barrero-Villar M. , Rey M. , Mittelbrunn M. , Lamana A. , Morlino G. , Calabia C. , Yamazaki H. , Shirao T. , Vazquez J. , Gonzalez-Amaro R. , Veiga E. , Sanchez-Madrid F.
J. Cell Sci.123:1160-1170(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DBN1;SUBCELLULAR LOCATION
47.

"Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4."
Malik R. , Marchese A.
Mol. Biol. Cell21:2529-2541(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBIQUITIN
48.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
49.

"Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway."
Cheng S.B. , Quinn J.A. , Graeber C.T. , Filardo E.J.
J. Biol. Chem.286:22441-22455(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
50.

"Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity."
Tadagaki K. , Tudor D. , Gbahou F. , Tschische P. , Waldhoer M. , Bomsel M. , Jockers R. , Kamal M.
Blood119:4908-4918(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-5 PROTEIN UL78
51.

"Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12)."
Veldkamp C.T. , Seibert C. , Peterson F.C. , Sakmar T.P. , Volkman B.F.
J. Mol. Biol.359:1400-1409(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-38;SULFATION AT TYR-21;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH CXCL12
52.

"Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12."
Veldkamp C.T. , Seibert C. , Peterson F.C. , De la Cruz N.B. , Haugner J.C. III , Basnet H. , Sakmar T.P. , Volkman B.F.
Sci. Signal.1:RA4-RA4(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-38 OF SULFATED MUTANT ALA-28 IN COMPLEX WITH CXCL12
53.

"Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists."
Wu B. , Chien E.Y. , Mol C.D. , Fenalti G. , Liu W. , Katritch V. , Abagyan R. , Brooun A. , Wells P. , Bi F.C. , Hamel D.J. , Kuhn P. , Handel T.M. , Cherezov V. , Stevens R.C.
Science330:1066-1071(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 2-325 OF MUTANTS LEU-125 AND THR-240 IN COMPLEX WITH ANTAGONISTS CVX15 AND IT1T;HOMODIMERIZATION;DISULFIDE BONDS

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