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Index > Protein center > CST3(Gene name) > Human
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  • CST3 (Gene name),
  • Cystatin-C (Protein name ),  CYTC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    CST3;
    Protein name:
    Cystatin-C;
    Alternative:
    Gamma-trace;Cystatin-3;Post-gamma-globulin;Neuroendocrine basic polypeptide;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    146
    Sequence:
    50:
    MAGPLRAPLL | LLAILAVALA | VSPAAGSSPG | KPPRLVGGPM | DASVEEEGVR | 
    100:
    RALDFAVGEY | NKASNDMYHS | RALQVVRARK | QIVAGVNYFL | DVELGRTTCT | 
    146:
    KTQPNLDNCP | FHDQPHLKRK | AFCSFQIYAV | PWQGTMTLSK | STCQDA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    SMR:
    MIM:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cystatin-C
    MSDS:
    Please sign in first.
    ELISA Kit for Human Cystatin-C
    Cat.:
    E0896m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Cystatin-C
    Cat.:
    E0896h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Cystatin-C
    Cat.:
    E0896r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Cystatin-C
    Cat.:
    E0896b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cystatin-C
    Cat.:
    U0896h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cystatin-C
    Cat.:
    U0896r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Cystatin-C
    Cat.:
    U0896m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Cystatin-C
    MSDS:
    Please sign in first.
    CLIA Kit for Human Cystatin-C
    Cat.:
    U0896b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Cystatin-C
    Cat.:
    P0896Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cystatin-C
    Polyclonal Antibody for Human Cystatin-C
    Polyclonal Antibody for Human Cystatin-C
    Cat.:
    P0896Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cystatin-C
    Cat.:
    P0896Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cystatin-C
    Monoclonal Antibody for Human Cystatin-C
    Monoclonal Antibody for Human Cystatin-C
    Monoclonal Antibody for Human Cystatin-C
    Monoclonal Antibody for Human Cystatin-C
    Cat.:
    M0896h
    Price:
    Please sign in first.
    Packing:
    40ug
    Protein for Human Cystatin-C
    Protein for Human Cystatin-C
    Protein for Human Cystatin-C
    Protein for Human Cystatin-C
    Protein for Human Cystatin-C

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    Linearity
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    References
    1. 1.
      "Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C."
      Abrahamson M. , Grubb A. , Olafsson I. , Lundwall A.
      FEBS Lett.216:229-233(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    2. 2.
      "The human cystatin C gene (CST3) is a member of the cystatin gene family which is localized on chromosome 20."
      Saitoh E. , Sabatini L.M. , Eddy R.L. , Shows T.B. , Azen E.A. , Isemura S. , Sanada K.
      Biochem. Biophys. Res. Commun.162:1324-1331(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-25
    3. 3.
      "Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases."
      Levy E. , Lopez-Otin C. , Ghiso J. , Geltner D. , Frangione B.
      J. Exp. Med.169:1771-1778(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT AMYL6 GLN-94
      tissue: Brain.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Leukocyte.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Synovial cell.
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    11. 11.
      "Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis."
      Grubb A. , Loefberg H.
      Proc. Natl. Acad. Sci. U.S.A.79:3024-3027(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-146
    12. 12.
      "Human cystatin, a new protein inhibitor of cysteine proteinases."
      Brzin J. , Popovic T. , Turk V.
      Biochem. Biophys. Res. Commun.118:103-109(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-76
    13. 13.
      "Protein inhibitors of cysteine proteinases. III. Amino-acid sequence of cystatin from chicken egg white."
      Turk V. , Brzin J. , Longer M. , Ritonja A. , Eropkin M. , Borchart U. , Machleidt W.
      Hoppe-Seyler's Z. Physiol. Chem.364:1487-1496(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-73
    14. 14.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-41
    15. 15.
      "The disulphide bridges of human cystatin C (gamma-trace) and chicken cystatin."
      Grubb A. , Loefberg H. , Barrett A.J.
      FEBS Lett.170:370-374(1984)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    16. 16.
      "Cystatin C as a potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease."
      Sanchez J.C. , Guillaume E. , Lescuyer P. , Allard L. , Carrette O. , Scherl A. , Burgess J. , Corthals G.L. , Burkhard P.R. , Hochstrasser D.F.
      Proteomics4:2229-2233(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    17. 17.
      "A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: an additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility."
      Ratnayaka A. , Paraoan L. , Spiller D.G. , Hiscott P. , Nelson G. , White M.R. , Grierson I.
      Exp. Eye Res.84:1135-1139(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ALA-25
    18. 18.
      "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
      Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS];STRUCTURE OF CARBOHYDRATES
      tissue: Cerebrospinal fluid.
    19. 19.
      "Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry."
      Ryan C.M. , Souda P. , Halgand F. , Wong D.T. , Loo J.A. , Faull K.F. , Whitelegge J.P.
      J. Am. Soc. Mass Spectrom.21:908-917(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;MASS SPECTROMETRY
      tissue: Saliva.
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping."
      Janowski R. , Kozak M. , Jankowska E. , Grzonka Z. , Grubb A. , Abrahamson M. , Jaskolski M.
      Nat. Struct. Biol.8:316-320(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 27-146
    22. 22.
      "3D domain-swapped human cystatin C with amyloid-like intermolecular beta-sheets."
      Janowski R. , Kozak M. , Abrahamson M. , Grubb A. , Jaskolski M.
      Proteins61:570-578(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.03 ANGSTROMS) OF 27-146
    23. 23.
      "Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis."
      Abrahamson M. , Jonsdottir S. , Olafsson I. , Jensson O. , Grubb A.
      Hum. Genet.89:377-380(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AMYL6 GLN-94
    24. 24.
      "CST3 genotype associated with exudative age related macular degeneration."
      Zurdel J. , Finckh U. , Menzer G. , Nitsch R.M. , Richard G.
      Br. J. Ophthalmol.86:214-219(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT THR-25 WITH ARMD11
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