Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > DAB2(Gene name) > Human
  • Add your favorite
  • DAB2 (Gene name),
  • Disabled homolog 2 (Protein name ),  DAB2_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    DAB2(DOC2);
    Protein name:
    Disabled homolog 2;
    Alternative:
    Differentially-expressed protein 2;DOC-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the globular tail of MYO6. Interacts with DAB2IP. Interacts with NOSTRIN.
    Function:
    Component of the CSF-1 signal transduction pathway.
    Subcellular Location:
    Cytoplasmic vesicle clathrin-coated vesicle membrane Membrane clathrin-coated pit Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles.
    Protein Attributes:
    Sequence length:
    770
    Sequence:
    50:
    MSNEVETSAT | NGQPDQQAAP | KAPSKKEKKK | GPEKTDEYLL | ARFKGDGVKY | 
    100:
    KAKLIGIDDV | PDARGDKMSQ | DSMMKLKGMA | AAGRSQGQHK | QRIWVNISLS | 
    150:
    GIKIIDEKTG | VIEHEHPVNK | ISFIARDVTD | NRAFGYVCGG | EGQHQFFAIK | 
    200:
    TGQQAEPLVV | DLKDLFQVIY | NVKKKEEEKK | KIEEASKAVE | NGSEALMILD | 
    250:
    DQTNKLKSGV | DQMDLFGDMS | TPPDLNSPTE | SKDILLVDLN | SEIDTNQNSL | 
    300:
    RENPFLTNGI | TSCSLPRPTP | QASFLPENAF | SANLNFFPTP | NPDPFRDDPF | 
    350:
    TQPDQSTPSS | FDSLKSPDQK | KENSSSSSTP | LSNGPLNGDV | DYFGQQFDQI | 
    400:
    SNRTGKQEAQ | AGPWPFSSSQ | TQPAVRTQNG | VSEREQNGFS | VKSSPNPFVG | 
    450:
    SPPKGLSIQN | GVKQDLESSV | QSSPHDSIAI | IPPPQSTKPG | RGRRTAKSSA | 
    500:
    NDLLASDIFA | PPVSEPSGQA | SPTGQPTALQ | PNPLDLFKTS | APAPVGPLVG | 
    550:
    LGGVTVTLPQ | AGPWNTASLV | FNQSPSMAPG | AMMGGQPSGF | SQPVIFGTSP | 
    600:
    AVSGWNQPSP | FAASTPPPVP | VVWGPSASVA | PNAWSTTSPL | GNPFQSNIFP | 
    650:
    APAVSTQPPS | MHSSLLVTPP | QPPPRAGPPK | DISSDAFTAL | DPLGDKEIKD | 
    700:
    VKEMFKDFQL | RQPPAVPARK | GEQTSSGTLS | AFASYFNSKV | GIPQENADHD | 
    750:
    DFDANQLLNK | INEPPKPAPR | QVSLPVTKST | DNAFENPFFK | DSFGSSQASV | 
    770:
    ASSQPVSSEM | YRDPFGNPFA | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    MIM:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Disabled homolog 2
    Cat.:
    E2121h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Disabled homolog 2
    Cat.:
    E2121m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Disabled homolog 2
    Cat.:
    E2121r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Disabled homolog 2
    Cat.:
    U2121m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Disabled homolog 2
    Cat.:
    U2121h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Disabled homolog 2
    Cat.:
    U2121r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Disabled homolog 2
    Cat.:
    P2121Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Disabled homolog 2
    Cat.:
    P2121Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Disabled homolog 2
    Cat.:
    P2121Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Disabled homolog 2
    Monoclonal Antibody for Human Disabled homolog 2
    Monoclonal Antibody for Human Disabled homolog 2
    Protein for Human Disabled homolog 2
    Protein for Human Disabled homolog 2
    Protein for Human Disabled homolog 2

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Sequence, genomic structure, and chromosomal assignment of human DOC-2."
      Albertsen H.M. , Smith S.A. , Melis R. , Williams B. , Holik P. , Stevens J. , White R.
      Genomics33:207-213(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
    2. 2.
      "DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer."
      Mok S.C. , Chan W.Y. , Wong K.-K. , Cheung K.K. , Lau C.C. , Ng S.W. , Baldini A. , Colitti C.V. , Rock C.O. , Berkowitz R.S.
      Oncogene16:2381-2387(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;ALTERNATIVE SPLICING
      tissue: Ovary.
    3. 3.
      "Disabled-2 inactivation is an early step in ovarian tumorigenicity."
      Fazili Z. , Sun W. , Mittelstaedt S. , Cohen C. , Xu X.-X.
      Oncogene18:3104-3113(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY
    4. 4.
      "Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2)."
      Sheng Z. , He J. , Tuppen J.A. , Sun W. , Fazili Z. , Smith E.R. , Dong F.B. , Xu X.-X.
      Genomics70:381-386(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 3)
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    7. 8.
      "Molecular cloning of differentially expressed genes in human epithelial ovarian cancer."
      Mok S.C. , Wong K.-K. , Chan R.K.W. , Lau C.C. , Tsao S.-W. , Knapp R.C. , Berkowitz R.S.
      Gynecol. Oncol.52:247-252(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-304 (ISOFORM 1)
      tissue: Ovary.
    8. 9.
      "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin."
      Oleinikov A.V. , Zhao J. , Makker S.P.
      Biochem. J.347:613-621(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP2
    9. 10.
      "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway."
      Hocevar B.A. , Smine A. , Xu X.X. , Howe P.H.
      EMBO J.20:2789-2801(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMAD2; SMAD3; TGFBR1 AND TGFBR2;MUTAGENESIS OF PHE-166
    10. 11.
      "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton."
      Morris S.M. , Arden S.D. , Roberts R.C. , Kendrick-Jones J. , Cooper J.A. , Luzio J.P. , Buss F.
      Traffic3:331-341(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYO6;SUBCELLULAR LOCATION;MUTAGENESIS OF 684-SER--PHE-686
    11. 12.
      "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."
      Howe P.H.
      EMBO J.22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DVL3 AND AXIN1
    12. 13.
      "Dab2 links CIN85 with clathrin-mediated receptor internalization."
      Kowanetz K. , Terzic J. , Dikic I.
      FEBS Lett.554:81-87(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH3KBP1;MUTAGENESIS OF ARG-720
    13. 14.
      "The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin."
      Gallagher H. , Oleinikov A.V. , Fenske C. , Newman D.J.
      Biochimie86:179-182(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP2;TISSUE SPECIFICITY
    14. 15.
      "The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer."
      Zhoul J. , Hernandez G. , Tu S.W. , Huang C.L. , Tseng C.P. , Hsieh J.T.
      Cancer Res.65:9906-9913(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 16.
      "The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH."
      Maurer M.E. , Cooper J.A.
      J. Cell Sci.119:4235-4246(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 17.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 19.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    19. 20.
      "Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins."
      Chao W.T. , Kunz J.
      FEBS Lett.583:1337-1343(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    20. 21.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 23.
      "Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis."
      Chetrit D. , Barzilay L. , Horn G. , Bielik T. , Smorodinsky N.I. , Ehrlich M.
      J. Biol. Chem.286:5392-5403(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    23. 24.
      "Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator."
      Fu L. , Rab A. , Tang L.P. , Rowe S.M. , Bebok Z. , Collawn J.F.
      Biochem. J.441:633-643(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    24. 25.
      "Disabled-2 (Dab2) inhibits Wnt/beta-catenin signalling by binding LRP6 and promoting its internalization through clathrin."
      Jiang Y. , He X. , Howe P.H.
      EMBO J.31:2336-2349(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LRP6
    25. 26.
      "FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis."
      Mulkearns E.E. , Cooper J.A.
      Mol. Biol. Cell23:1330-1342(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENDOCYTOSIS;INTERACTION WITH FCHO2
    26. 27.
      "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."
      Umasankar P.K. , Sanker S. , Thieman J.R. , Chakraborty S. , Wendland B. , Tsang M. , Traub L.M.
      Nat. Cell Biol.14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCHO1
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
    Top Searches
    Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Tumor necrosis Asprosin TRAP1A Alpha
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter