DAB2 ELISA Kit for Human(Homo sapiens) | EIAab.comDAB2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > DAB2(Gene name) > Human

DAB2 (Gene name),

Disabled homolog 2 (Protein name ), DAB2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

DAB2(DOC2);

Protein name:

Disabled homolog 2;

Alternative:

Differentially-expressed protein 2;DOC-2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with the globular tail of MYO6. Interacts with DAB2IP. Interacts with NOSTRIN.

Function:

Component of the CSF-1 signal transduction pathway.

Subcellular Location:

Cytoplasmic vesicle clathrin-coated vesicle membrane Membrane clathrin-coated pit Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles.

Protein Attributes:

Sequence length:

770

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

770:

ASSQPVSSEM | YRDPFGNPFA |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1601

UniGene:

Hs.696631

STRING:

9606.ENSP00000313391

SMR:

P98082

MIM:

601236

Pfam:

PF00640

String:

P98082

UniGene:

Hs.481980

Uniprot:

P98082

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ELISA Kit for Human Disabled homolog 2

Cat.:

E2121h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Disabled homolog 2

Cat.:

E2121m

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MSDS:

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Packing:

96T

ELISA Kit for Human Disabled homolog 2

Cat.:

E2121r

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MSDS:

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Packing:

96T

CLIA Kit for Human Disabled homolog 2

Cat.:

U2121m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Disabled homolog 2

Cat.:

U2121h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Disabled homolog 2

Cat.:

U2121r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Disabled homolog 2

Cat.:

P2121Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Disabled homolog 2

Cat.:

P2121Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Disabled homolog 2

Cat.:

P2121Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Disabled homolog 2

Protein for Human Disabled homolog 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Sequence, genomic structure, and chromosomal assignment of human DOC-2."
Albertsen H.M. , Smith S.A. , Melis R. , Williams B. , Holik P. , Stevens J. , White R.
Genomics33:207-213(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
2.

"DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer."
Mok S.C. , Chan W.Y. , Wong K.-K. , Cheung K.K. , Lau C.C. , Ng S.W. , Baldini A. , Colitti C.V. , Rock C.O. , Berkowitz R.S.
Oncogene16:2381-2387(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;ALTERNATIVE SPLICING
tissue: Ovary.
3.

"Disabled-2 inactivation is an early step in ovarian tumorigenicity."
Fazili Z. , Sun W. , Mittelstaedt S. , Cohen C. , Xu X.-X.
Oncogene18:3104-3113(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY
4.

"Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2)."
Sheng Z. , He J. , Tuppen J.A. , Sun W. , Fazili Z. , Smith E.R. , Dong F.B. , Xu X.-X.
Genomics70:381-386(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 3)
5.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Placenta.
8.

"Molecular cloning of differentially expressed genes in human epithelial ovarian cancer."
Mok S.C. , Wong K.-K. , Chan R.K.W. , Lau C.C. , Tsao S.-W. , Knapp R.C. , Berkowitz R.S.
Gynecol. Oncol.52:247-252(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-304 (ISOFORM 1)
tissue: Ovary.
9.

"Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin."
Oleinikov A.V. , Zhao J. , Makker S.P.
Biochem. J.347:613-621(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP2
10.

"The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway."
Hocevar B.A. , Smine A. , Xu X.X. , Howe P.H.
EMBO J.20:2789-2801(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMAD2; SMAD3; TGFBR1 AND TGFBR2;MUTAGENESIS OF PHE-166
11.

"Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton."
Morris S.M. , Arden S.D. , Roberts R.C. , Kendrick-Jones J. , Cooper J.A. , Luzio J.P. , Buss F.
Traffic3:331-341(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYO6;SUBCELLULAR LOCATION;MUTAGENESIS OF 684-SER--PHE-686
12.

"Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."
Howe P.H.
EMBO J.22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DVL3 AND AXIN1
13.

"Dab2 links CIN85 with clathrin-mediated receptor internalization."
Kowanetz K. , Terzic J. , Dikic I.
FEBS Lett.554:81-87(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH3KBP1;MUTAGENESIS OF ARG-720
14.

"The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin."
Gallagher H. , Oleinikov A.V. , Fenske C. , Newman D.J.
Biochimie86:179-182(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP2;TISSUE SPECIFICITY
15.

"The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer."
Zhoul J. , Hernandez G. , Tu S.W. , Huang C.L. , Tseng C.P. , Hsieh J.T.
Cancer Res.65:9906-9913(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH."
Maurer M.E. , Cooper J.A.
J. Cell Sci.119:4235-4246(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
20.

"Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins."
Chao W.T. , Kunz J.
FEBS Lett.583:1337-1343(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
21.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis."
Chetrit D. , Barzilay L. , Horn G. , Bielik T. , Smorodinsky N.I. , Ehrlich M.
J. Biol. Chem.286:5392-5403(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
24.

"Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator."
Fu L. , Rab A. , Tang L.P. , Rowe S.M. , Bebok Z. , Collawn J.F.
Biochem. J.441:633-643(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
25.

"Disabled-2 (Dab2) inhibits Wnt/beta-catenin signalling by binding LRP6 and promoting its internalization through clathrin."
Jiang Y. , He X. , Howe P.H.
EMBO J.31:2336-2349(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LRP6
26.

"FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis."
Mulkearns E.E. , Cooper J.A.
Mol. Biol. Cell23:1330-1342(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENDOCYTOSIS;INTERACTION WITH FCHO2
27.

"Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."
Umasankar P.K. , Sanker S. , Thieman J.R. , Chakraborty S. , Wendland B. , Tsang M. , Traub L.M.
Nat. Cell Biol.14:488-501(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCHO1

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