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Index > Protein center > DDAH1(Gene name) > Human
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  • DDAH1 (Gene name),
  • N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (Protein name ),  DDAH1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DDAH1(DDAH);
    Protein name:
    N(G),N(G)-dimethylarginine dimethylaminohydrolase 1(DDAH-1;Dimethylarginine dimethylaminohydrolase 1);
    Alternative:
    Dimethylargininase-1;DDAHI;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    285
    Sequence:
    50:
    MAGLGHPAAF | GRATHAVVRA | LPESLGQHAL | RSAKGEEVDV | ARAERQHQLY | 
    100:
    VGVLGSKLGL | QVVELPADES | LPDCVFVEDV | AVVCEETALI | TRPGAPSRRK | 
    150:
    EVDMMKEALE | KLQLNIVEMK | DENATLDGGD | VLFTGREFFV | GLSKRTNQRG | 
    200:
    AEILADTFKD | YAVSTVPVAD | GLHLKSFCSM | AGPNLIAIGS | SESAQKALKI | 
    250:
    MQQMSDHRYD | KLTVPDDIAA | NCIYLNIPNK | GHVLLHRTPE | EYPESAKVYE | 
    285:
    KLKDHMLIPV | SMSELEKVDG | LLTCCSVLIN | KKVDS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    String:
    MIM:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human DDAH-1
    Cat.:
    E0300r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human DDAH-1
    Cat.:
    E0300m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human DDAH-1
    Cat.:
    E0300h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human DDAH-1
    Cat.:
    E0300b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DDAH-1
    Cat.:
    U0300h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human DDAH-1
    Cat.:
    U0300r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DDAH-1
    Cat.:
    U0300m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DDAH-1
    Cat.:
    U0300b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human DDAH-1
    Cat.:
    P0300Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DDAH-1
    Cat.:
    P0300Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DDAH-1
    Polyclonal Antibody for Human DDAH-1
    Cat.:
    P0300Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human DDAH-1
    Monoclonal Antibody for Human DDAH-1
    Monoclonal Antibody for Human DDAH-1
    Monoclonal Antibody for Human DDAH-1
    Protein for Human DDAH-1
    Protein for Human DDAH-1
    Protein for Human DDAH-1
    Protein for Human DDAH-1

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    References
    1. 1.
      "Purification, cDNA cloning and expression of human NG,NG-dimethylarginine dimethylaminohydrolase."
      Kimoto M. , Miyatake S. , Sasagawa T. , Yamashita H. , Okita M. , Oka T. , Ogawa T. , Tsuji H.
      Eur. J. Biochem.258:863-868(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 2-12 AND 35-50;ABSENCE OF BOUND ZINC;ACETYLATION AT ALA-2
      tissue: Kidney.
      tissue: Liver.
    2. 2.
      "Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases."
      Leiper J.M. , Santa Maria J. , Chubb A. , MacAllister R.J. , Charles I.G. , Whitley G.S. , Vallance P.
      Biochem. J.343:209-214(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Endometrial cancer.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
      tissue: Kidney.
      tissue: Stomach.
      tissue: Testis.
    7. 7.
      Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-31; 46-57; 112-136; 150-196; 212-230 AND 268-281;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    8. 8.
      "Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in NO regulation."
      Forbes S.P. , Druhan L.J. , Guzman J.E. , Parinandi N. , Zhang L. , Green-Church K.B. , Cardounel A.J.
      Biochemistry47:1819-1826(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;ENZYME REGULATION;IDENTIFICATION BY MASS SPECTROMETRY;BIOPHYSICOCHEMICAL PROPERTIES
    9. 9.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 2-284 IN COMPLEXES WITH CITRULLINE AND INHIBITOR L-257
    12. 12.
      "Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide."
      Wang Y. , Monzingo A.F. , Hu S. , Schaller T.H. , Robertus J.D. , Fast W.
      Biochemistry48:8624-8635(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH N-1-IMINOPROPYL-L-ORNITHINE;CATALYTIC ACTIVITY;ZINC-BINDING;ENZYME REGULATION;SUBUNIT;BIOPHYSICOCHEMICAL PROPERTIES;ACTIVE SITE;MUTAGENESIS OF LEU-30; GLU-78 AND LEU-271;IDENTIFICATION BY MASS SPECTROMETRY
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