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Index > Protein center > DDC(Gene name) > Human
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  • DDC (Gene name),
  • Aromatic-L-amino-acid decarboxylase (Protein name ),  DDC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    DDC(AADC);
    Protein name:
    Aromatic-L-amino-acid decarboxylase(AADC);
    Alternative:
    DOPA decarboxylase(DDC);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    480
    Sequence:
    50:
    MNASEFRRRG | KEMVDYMANY | MEGIEGRQVY | PDVEPGYLRP | LIPAAAPQEP | 
    100:
    DTFEDIINDV | EKIIMPGVTH | WHSPYFFAYF | PTASSYPAML | ADMLCGAIGC | 
    150:
    IGFSWAASPA | CTELETVMMD | WLGKMLELPK | AFLNEKAGEG | GGVIQGSASE | 
    200:
    ATLVALLAAR | TKVIHRLQAA | SPELTQAAIM | EKLVAYSSDQ | AHSSVERAGL | 
    250:
    IGGVKLKAIP | SDGNFAMRAS | ALQEALERDK | AAGLIPFFMV | ATLGTTTCCS | 
    300:
    FDNLLEVGPI | CNKEDIWLHV | DAAYAGSAFI | CPEFRHLLNG | VEFADSFNFN | 
    350:
    PHKWLLVNFD | CSAMWVKKRT | DLTGAFRLDP | TYLKHSHQDS | GLITDYRHWQ | 
    400:
    IPLGRRFRSL | KMWFVFRMYG | VKGLQAYIRK | HVQLSHEFES | LVRQDPRFEI | 
    450:
    CVEVILGLVC | FRLKGSNKVN | EALLQRINSA | KKIHLVPCHL | RDKFVLRFAI | 
    480:
    CSRTVESAHV | QRAWEHIKEL | AADVLRAERE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human AADC
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    E1431h
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    ELISA Kit for Human AADC
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    E1431m
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    96T
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    ELISA Kit for Human AADC
    Cat.:
    E1431r
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    96T
    ELISA Kit for Human AADC
    Cat.:
    E1431b
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    96T
    ELISA Kit for Human AADC
    Cat.:
    E1431p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AADC
    Cat.:
    U1431p
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    Packing:
    96T
    CLIA Kit for Human AADC
    Cat.:
    U1431r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AADC
    Cat.:
    U1431b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AADC
    Cat.:
    U1431m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AADC
    Cat.:
    U1431h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human AADC
    Polyclonal Antibody for Human AADC
    Cat.:
    P1431Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AADC
    Polyclonal Antibody for Human AADC
    Cat.:
    P1431Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AADC
    Cat.:
    P1431Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human AADC
    Monoclonal Antibody for Human AADC
    Monoclonal Antibody for Human AADC
    Monoclonal Antibody for Human AADC
    Monoclonal Antibody for Human AADC
    Protein for Human AADC
    Protein for Human AADC
    Protein for Human AADC
    Protein for Human AADC
    Protein for Human AADC

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    References
    1. 1.
      "Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase."
      Ichinose H. , Kurosawa Y. , Titani K. , Fujita K. , Nagatsu T.
      Biochem. Biophys. Res. Commun.164:1024-1030(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-17
      tissue: Pheochromocytoma.
    2. 2.
      "Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs."
      Scherer L.J. , McPherson J.D. , Wasmuth J.J. , Marsh L.J.
      Genomics13:469-471(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-17
    3. 3.
      "Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis."
      Sumi-Ichinose C. , Ichinose H. , Takahashi E. , Hori T. , Nagatsu T.
      Biochemistry31:2229-2238(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];DISEASE;VARIANT VAL-17
    4. 4.
      "Identification and characterization of a novel form of the human L-dopa decarboxylase mRNA."
      Vassilacopoulou D.S. , Sideris D.C. , Vassiliou A.G. , Fragoulis E.G.
      Neurochem. Res.29:1817-1823(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING;VARIANT VAL-17
      tissue: Placenta.
    5. 5.
      NIEHS SNPs program
      Submitted (2004-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-17; ASP-61; LEU-210; VAL-217; LEU-239; ILE-239 AND GLN-462
    6. 6.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-17
      tissue: Lung.
    8. 8.
      "Identification of a neuron-specific promoter of human aromatic L-amino acid decarboxylase gene."
      Van Thai A. , Coste E. , Allen J.M. , Palmiter R.D. , Weber M.J.
      Brain Res. Mol. Brain Res.17:227-238(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67;VARIANT VAL-17
    9. 9.
      "Localisation of the gene for human aromatic L-amino acid decarboxylase (DDC) to chromosome 7p13-->p11 by in situ hybridisation."
      Craig S.P. , Thai A.L. , Weber M. , Craig I.W.
      Cytogenet. Cell Genet.61:114-116(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-105
    10. 10.
      "Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases."
      Giardina G. , Montioli R. , Gianni S. , Cellini B. , Paiardini A. , Voltattorni C.B. , Cutruzzola F.
      Proc. Natl. Acad. Sci. U.S.A.108:20514-20519(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS);COFACTOR-BINDING SITES;SUBUNIT
    11. 11.
      "Mutations in the human aromatic L-amino acid decarboxylase gene."
      Chang Y.T. , Mues G. , McPherson J.D. , Bedell J. , Marsh J.L. , Hyland K. , Courtwright K.H. , Summers J.W.
      J. Inherit. Metab. Dis.21:4-4(1998)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AADCD VAL-91; SER-102; ARG-147; PHE-250; THR-275 AND LEU-309
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-17; LEU-210 AND VAL-217
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    14. 14.
      "Levodopa-responsive aromatic L-amino acid decarboxylase deficiency."
      Chang Y.T. , Sharma R. , Marsh J.L. , McPherson J.D. , Bedell J.A. , Knust A. , Braeutigam C. , Hoffmann G.F. , Hyland K.
      Ann. Neurol.55:435-438(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AADCD SER-102
    15. 15.
      "Aromatic L-amino acid decarboxylase deficiency: clinical features, treatment, and prognosis."
      Pons R. , Ford B. , Chiriboga C.A. , Clayton P.T. , Hinton V. , Hyland K. , Sharma R. , De Vivo D.C.
      Neurology62:1058-1065(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AADCD HIS-47; PHE-250; GLN-347 AND ILE-408
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