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Index > Protein center > DDIT3(Gene name) > Human
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  • DDIT3 (Gene name),
  • DNA damage-inducible transcript 3 protein (Protein name ),  DDIT3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DDIT3(CHOP;CHOP10;GADD153);
    Protein name:
    DNA damage-inducible transcript 3 protein(DDIT-3);
    Alternative:
    C/EBP-homologous protein 10(CHOP-10);C/EBP-homologous protein(CHOP);CCAAT/enhancer-binding protein homologous protein;Growth arrest and DNA damage-inducible protein GADD153(CHOP-10);Growth arrest and DNA damage-inducible protein GADD153;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer.
    Function:
    Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    169
    Sequence:
    50:
    MAAESLPFSF | GTLSSWELEA | WYEDLQEVLS | SDENGGTYVS | PPGNEEEESK | 
    100:
    IFTTLDPASL | AWLTEEEPEP | AEVTSTSQSP | HSPDSSQSSL | AQEEEEEDQG | 
    150:
    RTRKRKQSGH | SPARAGKQRM | KEKEQENERK | VAQLAEENER | LKQEIERLTR | 
    169:
    EVEATRRALI | DRMVNLHQA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human DDIT-3
    Cat.:
    E9115h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human DDIT-3
    Cat.:
    E9115r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human DDIT-3
    Cat.:
    E9115m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human DDIT-3
    Cat.:
    E9115b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DDIT-3
    Cat.:
    U9115r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DDIT-3
    Cat.:
    U9115h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human DDIT-3
    Cat.:
    U9115m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DDIT-3
    Cat.:
    U9115b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human DDIT-3
    Polyclonal Antibody for Human DDIT-3
    Polyclonal Antibody for Human DDIT-3
    Cat.:
    P9115Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DDIT-3
    Cat.:
    P9115Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human DDIT-3
    Monoclonal Antibody for Human DDIT-3
    Monoclonal Antibody for Human DDIT-3
    Monoclonal Antibody for Human DDIT-3
    Protein for Human DDIT-3
    Protein for Human DDIT-3
    Protein for Human DDIT-3
    Protein for Human DDIT-3

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    References
    1. 1.
      "Isolation, characterization and chromosomal localization of the human GADD153 gene."
      Park J.S. , Luethy J.D. , Wang M.G. , Fargnoli J. , Fornace A.J. Jr. , McBride O.W. , Holbrook N.J.
      Gene116:259-267(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma."
      Crozat A. , Aman P. , Mandahl N. , Ron D.
      Nature363:640-644(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma."
      Rabbitts T.H. , Forster A. , Larson R. , Nathan P.
      Nat. Genet.4:175-180(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INVOLVEMENT IN MXLIPO;CHROMOSOMAL TRANSLOCATION WITH FUS
    4. 4.
      Li X. , Xie Y. , Mao Y.
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    5. 5.
      NIEHS SNPs program
      Submitted (2005-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
    8. 8.
      "Roles of CHOP/GADD153 in endoplasmic reticulum stress."
      Oyadomari S. , Mori M.
      Cell Death Differ.11:381-389(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    9. 9.
      "CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells."
      Yamaguchi H. , Wang H.G.
      J. Biol. Chem.279:45495-45502(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."
      Ohoka N. , Yoshii S. , Hattori T. , Onozaki K. , Hayashi H.
      EMBO J.24:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRIB3
    11. 11.
      "The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals."
      Horndasch M. , Lienkamp S. , Springer E. , Schmitt A. , Pavenstaedt H. , Walz G. , Gloy J.
      Oncogene25:3397-3407(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TCF7L2
    12. 12.
      "Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion."
      Ohoka N. , Hattori T. , Kitagawa M. , Onozaki K. , Hayashi H.
      J. Biol. Chem.282:35687-35694(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: N-TERMINAL REGION;SUBCELLULAR LOCATION;INTERACTION WITH TRIB3; EP300; HDAC1; HDAC5 AND HDAC6;UBIQUITINATION;PROTEASOMAL DEGRADATION
    13. 13.
      "CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells."
      Vij N. , Amoako M.O. , Mazur S. , Zeitlin P.L.
      Am. J. Respir. Cell Mol. Biol.38:176-184(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene."
      Su N. , Kilberg M.S.
      J. Biol. Chem.283:35106-35117(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ATF4
    15. 15.
      "Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling."
      Woo C.W. , Cui D. , Arellano J. , Dorweiler B. , Harding H. , Fitzgerald K.A. , Ron D. , Tabas I.
      Nat. Cell Biol.11:1473-1480(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    16. 16.
      "ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity."
      Oliveira S.J. , Pinto J.P. , Picarote G. , Costa V.M. , Carvalho F. , Rangel M. , de Sousa M. , de Almeida S.F.
      PLoS ONE4:E6618-E6618(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma."
      Park S.H. , Choi H.J. , Yang H. , Do K.H. , Kim J. , Lee D.W. , Moon Y.
      J. Biol. Chem.285:35330-35339(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CEBPB;INDUCTION
    18. 18.
      "Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression."
      Goodall J.C. , Wu C. , Zhang Y. , McNeill L. , Ellis L. , Saudek V. , Gaston J.S.
      Proc. Natl. Acad. Sci. U.S.A.107:17698-17703(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    19. 19.
      "CHOP is a multifunctional transcription factor in the ER stress response."
      Nishitoh H.
      J. Biochem.151:217-219(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    20. 20.
      "CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress."
      Ghosh A.P. , Klocke B.J. , Ballestas M.E. , Roth K.A.
      PLoS ONE7:E39586-E39586(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FOXO3;SUBCELLULAR LOCATION
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-115
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