Gene name:
DDR1 (CAK;EDDR1;NEP;NTRK4;PTK3A;RTK6;TRKE) ;
Protein name:
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) ;
Alternative:
Tyrosine-protein kinase CAK ;Cell adhesion kinase ;CD167 antigen-like family member A ;HGK2 ;Discoidin receptor tyrosine kinase ;Protein-tyrosine kinase 3A ;Mammary carcinoma kinase 10 (MCK-10) ;TRK E ;Protein-tyrosine kinase RTK-6 ;Tyrosine kinase DDR ;
CD:
CD167a ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen.
Function:
May be involved in cell-cell interactions and recognition.
Subcellular Location:
Isoform 4
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MGPEALSSLL | LLLLVASGDA | DMKGHFDPAK | CRYALGMQDR | TIPDSDISAS |
100:
SSWSDSTAAR | HSRLESSDGD | GAWCPAGSVF | PKEEEYLQVD | LQRLHLVALV |
150:
GTQGRHAGGL | GKEFSRSYRL | RYSRDGRRWM | GWKDRWGQEV | ISGNEDPEGV |
200:
VLKDLGPPMV | ARLVRFYPRA | DRVMSVCLRV | ELYGCLWRDG | LLSYTAPVGQ |
250:
TMYLSEAVYL | NDSTYDGHTV | GGLQYGGLGQ | LADGVVGLDD | FRKSQELRVW |
300:
PGYDYVGWSN | HSFSSGYVEM | EFEFDRLRAF | QAMQVHCNNM | HTLGARLPGG |
350:
VECRFRRGPA | MAWEGEPMRH | NLGGNLGDPR | ARAVSVPLGG | RVARFLQCRF |
400:
LFAGPWLLFS | EISFISDVVN | NSSPALGGTF | PPAPWWPPGP | PPTNFSSLEL |
450:
EPRGQQPVAK | AEGSPTAILI | GCLVAIILLL | LLIIALMLWR | LHWRRLLSKA |
500:
ERRVLEEELT | VHLSVPGDTI | LINNRPGPRE | PPPYQEPRPR | GNPPHSAPCV |
550:
PNGSALLLSN | PAYRLLLATY | ARPPRGPGPP | TPAWAKPTNT | QAYSGDYMEP |
600:
EKPGAPLLPP | PPQNSVPHYA | EADIVTLQGV | TGGNTYAVPA | LPPGAVGDGP |
650:
PRVDFPRSRL | RFKEKLGEGQ | FGEVHLCEVD | SPQDLVSLDF | PLNVRKGHPL |
700:
LVAVKILRPD | ATKNARNDFL | KEVKIMSRLK | DPNIIRLLGV | CVQDDPLCMI |
750:
TDYMENGDLN | QFLSAHQLED | KAAEGAPGDG | QAAQGPTISY | PMLLHVAAQI |
800:
ASGMRYLATL | NFVHRDLATR | NCLVGENFTI | KIADFGMSRN | LYAGDYYRVQ |
850:
GRAVLPIRWM | AWECILMGKF | TTASDVWAFG | VTLWEVLMLC | RAQPFGQLTD |
900:
EQVIENAGEF | FRDQGRQVYL | SRPPACPQGL | YELMLRCWSR | ESEQRPPFSQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Epithelial discoidin domain receptor 1
ELISA Kit for Human Epithelial discoidin domain receptor 1
ELISA Kit for Human Epithelial discoidin domain receptor 1
CLIA Kit for Human Epithelial discoidin domain receptor 1
CLIA Kit for Human Epithelial discoidin domain receptor 1
CLIA Kit for Human Epithelial discoidin domain receptor 1
Polyclonal Antibody for Human Epithelial discoidin domain receptor 1
Polyclonal Antibody for Human Epithelial discoidin domain receptor 1
Polyclonal Antibody for Human Epithelial discoidin domain receptor 1
Monoclonal Antibody for Human Epithelial discoidin domain receptor 1
Monoclonal Antibody for Human Epithelial discoidin domain receptor 1
Monoclonal Antibody for Human Epithelial discoidin domain receptor 1
Protein for Human Epithelial discoidin domain receptor 1
Protein for Human Epithelial discoidin domain receptor 1
Protein for Human Epithelial discoidin domain receptor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5)
tissue :
Brain .
tissue :
Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
tissue :
Muscle .
15.
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Cited for : PROTEIN SEQUENCE OF 480-490; 515-525 AND 790-798;IDENTIFICATION BY MASS SPECTROMETRY;SUBUNIT;SUBCELLULAR LOCATION;PHOSPHORYLATION AT TYR-484; TYR-513; TYR-520; TYR-792; TYR-796 AND TYR-797;GLYCOSYLATION AT ASN-211 AND ASN-260;MUTAGENESIS OF ARG-105; ASN-211; SER-213; ASN-260; ASN-371; THR-379; THR-393; ASN-394 AND LYS-655
16.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 501-550 (ISOFORMS 1/4);NUCLEOTIDE SEQUENCE [MRNA] OF 501-550 AND 651-694 (ISOFORM 2);NUCLEOTIDE SEQUENCE [MRNA] OF 651-694 (ISOFORM 4);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
tissue :
Mammary carcinoma .
17.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 771-824 (ISOFORMS 1/2/4)
18.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 772-823 (ISOFORMS 1/2/4);TISSUE SPECIFICITY
tissue :
Melanocyte .
19.
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Cited for : FUNCTION AS COLLAGEN RECEPTOR;PHOSPHORYLATION AT TYR-513;INTERACTION WITH SHC1;AUTOPHOSPHORYLATION;SUBCELLULAR LOCATION
20.
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Cited for : FUNCTION
21.
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Cited for : FUNCTION;INTERACTION WITH PTPN11 AND NCK2;PHOSPHORYLATION AT TYR-740;MUTAGENESIS OF TYR-740
22.
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Cited for : FUNCTION
23.
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Cited for : INTERACTION WITH WWC1 AND PRKCZ
24.
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Cited for : FUNCTION;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION;INTERACTION WITH MYH9
25.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.
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Cited for : FUNCTION;INTERACTION WITH CDH1
27.
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Cited for : FUNCTION;INTERACTION WITH SRC
28.
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Cited for : FUNCTION
29.
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Cited for : FUNCTION AS COLLAGEN RECEPTOR;AUTOPHOSPHORYLATION
30.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 29-367 IN COMPLEX WITH INHIBITORY ANTIBODY;SUBUNIT;CALCIUM-BINDING SITES;GLYCOSYLATION AT ASN-211 AND ASN-260;DISULFIDE BONDS
31.
"Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor."
Kim H.G.
,
Tan L.
,
Weisberg E.L.
,
Liu F.
,
Canning P.
,
Choi H.G.
,
Ezell S.A.
,
Wu H.
,
Zhao Z.
,
Wang J.
,
Mandinova A.
,
Griffin J.D.
,
Bullock A.N.
,
Liu Q.
,
Lee S.W.
,
Gray N.S.
ACS Chem. Biol.8:2145-2150(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 601-913 IN COMPLEX WITH INHIBITOR;AUTOPHOSPHORYLATION;MUTAGENESIS OF GLY-707
32.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 601-913 IN COMPLEXES WITH INHIBITORS IMATINIB AND PONATINIB;ENZYME REGULATION;AUTOPHOSPHORYLATION
33.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] GLY-17; ALA-100; GLN-169; ASP-170; TRP-306 AND ALA-496