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Index > Protein center > DDR2(Gene name) > Human
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  • DDR2 (Gene name),
  • Discoidin domain-containing receptor 2 (Protein name ),  DDR2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DDR2(NTRKR3;TKT;TYRO10);
    Protein name:
    Discoidin domain-containing receptor 2(Discoidin domain receptor 2);
    Alternative:
    Discoidin domain-containing receptor tyrosine kinase 2;CD167 antigen-like family member B;Receptor protein-tyrosine kinase TKT;Neurotrophic tyrosine kinase, receptor-related 3;Tyrosine-protein kinase TYRO10;
    CD:
    CD167b;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.
    Function:
    Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration, cell proliferation, and cell cycle progress. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. Depending on the cell type, promotes or inhibits cell proliferation. Can mediate cell cycle arrest in some types of tumor cells.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    855
    Sequence:
    50:
    MILIPRMLLV | LFLLLPILSS | AKAQVNPAIC | RYPLGMSGGQ | IPDEDITASS | 
    100:
    QWSESTAAKY | GRLDSEEGDG | AWCPEIPVEP | DDLKEFLQID | LHTLHFITLV | 
    150:
    GTQGRHAGGH | GIEFAPMYKI | NYSRDGTRWI | SWRNRHGKQV | LDGNSNPYDI | 
    200:
    FLKDLEPPIV | ARFVRFIPVT | DHSMNVCMRV | ELYGCVWLDG | LVSYNAPAGQ | 
    250:
    QFVLPGGSII | YLNDSVYDGA | VGYSMTEGLG | QLTDGVSGLD | DFTQTHEYHV | 
    300:
    WPGYDYVGWR | NESATNGYIE | IMFEFDRIRN | FTTMKVHCNN | MFAKGVKIFK | 
    350:
    EVQCYFRSEA | SEWEPNAISF | PLVLDDVNPS | ARFVTVPLHH | RMASAIKCQY | 
    400:
    HFADTWMMFS | EITFQSDAAM | YNNSEALPTS | PMAPTTYDPM | LKVDDSNTRI | 
    450:
    LIGCLVAIIF | ILLAIIVIIL | WRQFWQKMLE | KASRRMLDDE | MTVSLSLPSD | 
    500:
    SSMFNNNRSS | SPSEQGSNST | YDRIFPLRPD | YQEPSRLIRK | LPEFAPGEEE | 
    550:
    SGCSGVVKPV | QPSGPEGVPH | YAEADIVNLQ | GVTGGNTYSV | PAVTMDLLSG | 
    600:
    KDVAVEEFPR | KLLTFKEKLG | EGQFGEVHLC | EVEGMEKFKD | KDFALDVSAN | 
    650:
    QPVLVAVKML | RADANKNARN | DFLKEIKIMS | RLKDPNIIHL | LAVCITDDPL | 
    700:
    CMITEYMENG | DLNQFLSRHE | PPNSSSSDVR | TVSYTNLKFM | ATQIASGMKY | 
    750:
    LSSLNFVHRD | LATRNCLVGK | NYTIKIADFG | MSRNLYSGDY | YRIQGRAVLP | 
    800:
    IRWMSWESIL | LGKFTTASDV | WAFGVTLWET | FTFCQEQPYS | QLSDEQVIEN | 
    850:
    TGEFFRDQGR | QTYLPQPAIC | PDSVYKLMLS | CWRRDTKNRP | SFQEIHLLLL | 
    855:
    QQGDE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Discoidin domain receptor 2
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    E1505h
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    ELISA Kit for Human Discoidin domain receptor 2
    Cat.:
    E1505m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Discoidin domain receptor 2
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    U1505m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Discoidin domain receptor 2
    Cat.:
    U1505h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Discoidin domain receptor 2
    Cat.:
    P1505Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Discoidin domain receptor 2
    Cat.:
    P1505Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Discoidin domain receptor 2
    Monoclonal Antibody for Human Discoidin domain receptor 2
    Protein for Human Discoidin domain receptor 2
    Protein for Human Discoidin domain receptor 2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain."
      Karn T. , Holtrich U. , Braeuninger A. , Boehme B. , Wolf G. , Ruebsamen-Waigmann H. , Strebhardt K.
      Oncogene8:3433-3440(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Heart.
      tissue: Thymus.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Hair follicle dermal papilla.
      tissue: Uterus.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    6. 6.
      "The discoidin domain receptor tyrosine kinases are activated by collagen."
      Vogel W. , Gish G.D. , Alves F. , Pawson T.
      Mol. Cell1:13-23(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS COLLAGEN RECEPTOR AND IN UP-REGULATION OF MMP1;PHOSPHORYLATION;SUBCELLULAR LOCATION
    7. 7.
      "Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation."
      Yang K. , Kim J.H. , Kim H.J. , Park I.S. , Kim I.Y. , Yang B.S.
      J. Biol. Chem.280:39058-39066(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF MMP1 AND MMP2;PHOSPHORYLATION AT TYR-736; TYR-740 AND TYR-741;CATALYTIC ACTIVITY;ENZYME REGULATION;INTERACTION WITH SHC1;MUTAGENESIS OF LYS-608; TYR-736; TYR-740 AND TYR-741
    8. 8.
      "Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen."
      Wall S.J. , Werner E. , Werb Z. , DeClerck Y.A.
      J. Biol. Chem.280:40187-40194(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS COLLAGEN RECEPTOR;PHOSPHORYLATION
    9. 9.
      "Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis."
      Xu L. , Peng H. , Glasson S. , Lee P.L. , Hu K. , Ijiri K. , Olsen B.R. , Goldring M.B. , Li Y.
      Arthritis Rheum.56:2663-2673(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UP-REGULATION OF MMP13;INDUCTION;TISSUE SPECIFICITY
    10. 10.
      "Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen."
      Konitsiotis A.D. , Raynal N. , Bihan D. , Hohenester E. , Farndale R.W. , Leitinger B.
      J. Biol. Chem.283:6861-6868(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS COLLAGEN RECEPTOR;SUBCELLULAR LOCATION;PHOSPHORYLATION;SUBUNIT
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation."
      Lin K.L. , Chou C.H. , Hsieh S.C. , Hwa S.Y. , Lee M.T. , Wang F.F.
      J. Bone Miner. Res.25:2489-2503(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN OSTEOBLAST DIFFERENTIATION VIA ACTIVATION OF RUNX2;INDUCTION;TISSUE SPECIFICITY
    14. 14.
      "An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation."
      Zhang Y. , Su J. , Yu J. , Bu X. , Ren T. , Liu X. , Yao L.
      J. Bone Miner. Res.26:604-617(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN OSTEOBLAST DIFFERENTIATION AND CHONDROCYTE MATURATION VIA ACTIVATION OF RUNX2
    15. 15.
      "Sensing extracellular matrix: an update on discoidin domain receptor function."
      Vogel W.F. , Abdulhussein R. , Ford C.E.
      Cell. Signal.18:1108-1116(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    17. 17.
      "Structural basis of the collagen-binding mode of discoidin domain receptor 2."
      Ichikawa O. , Osawa M. , Nishida N. , Goshima N. , Nomura N. , Shimada I.
      EMBO J.26:4168-4176(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 22-186;INTERACTION WITH COLLAGEN;DISULFIDE BONDS
    18. 18.
      "Crystallographic insight into collagen recognition by discoidin domain receptor 2."
      Carafoli F. , Bihan D. , Stathopoulos S. , Konitsiotis A.D. , Kvansakul M. , Farndale R.W. , Leitinger B. , Hohenester E.
      Structure17:1573-1581(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 26-190 IN COMPLEX WITH COLLAGEN PEPTIDE;DISULFIDE BONDS;MUTAGENESIS OF TRP-52;FUNCTION IN COLLAGEN BINDING;CATALYTIC ACTIVITY;PHOSPHORYLATION
    19. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SEMD-SL ILE-713; ARG-726 AND CYS-752
    20. 22.
      "Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients."
      Ali B.R. , Xu H. , Akawi N.A. , John A. , Karuvantevida N.S. , Langer R. , Al-Gazali L. , Leitinger B.
      Hum. Mol. Genet.19:2239-2250(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SEMD-SL LYS-113;CHARACTERIZATION OF VARIANTS SEMD-SL LYS-113; ILE-713; ARG-726 AND CYS-752;MUTAGENESIS OF TRP-52;GLYCOSYLATION;SUBCELLULAR LOCATION
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