Gene name:
DKK2 (UNQ682/PRO1316) ;
Protein name:
Dickkopf-related protein 2 (Dickkopf-2;Dkk-2;hDkk-2) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with LRP5 and LRP6.
Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Subcellular Location:
Secreted
Protein Attributes:
50:
MAALMRSKDS | SCCLLLLAAV | LMVESSQIGS | SRAKLNSIKS | SLGGETPGQA |
100:
ANRSAGMYQG | LAFGGSKKGK | NLGQAYPCSS | DKECEVGRYC | HSPHQGSSAC |
150:
MVCRRKKKRC | HRDGMCCPST | RCNNGICIPV | TESILTPHIP | ALDGTRHRDR |
200:
NHGHYSNHDL | GWQNLGRPHT | KMSHIKGHEG | DPCLRSSDCI | EGFCCARHFW |
250:
TKICKPVLHQ | GEVCTKQRKK | GSHGLEIFQR | CDCAKGLSCK | VWKDATYSSK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Dickkopf-2
ELISA Kit for Human Dickkopf-2
CLIA Kit for Human Dickkopf-2
CLIA Kit for Human Dickkopf-2
Polyclonal Antibody for Human Dickkopf-2
Polyclonal Antibody for Human Dickkopf-2
Monoclonal Antibody for Human Dickkopf-2
Monoclonal Antibody for Human Dickkopf-2
Protein for Human Dickkopf-2
Protein for Human Dickkopf-2
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Fetal lung .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-146
tissue :
Brain .
tissue :
Testis .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-259
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW OF THE DKK FAMILY