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Index > Protein center > DKK2(Gene name) > Human
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  • DKK2 (Gene name),
  • Dickkopf-related protein 2 (Protein name ),  DKK2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    DKK2(UNQ682/PRO1316);
    Protein name:
    Dickkopf-related protein 2(Dickkopf-2;Dkk-2;hDkk-2);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with LRP5 and LRP6.
    Function:
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    259
    Sequence:
    50:
    MAALMRSKDS | SCCLLLLAAV | LMVESSQIGS | SRAKLNSIKS | SLGGETPGQA | 
    100:
    ANRSAGMYQG | LAFGGSKKGK | NLGQAYPCSS | DKECEVGRYC | HSPHQGSSAC | 
    150:
    MVCRRKKKRC | HRDGMCCPST | RCNNGICIPV | TESILTPHIP | ALDGTRHRDR | 
    200:
    NHGHYSNHDL | GWQNLGRPHT | KMSHIKGHEG | DPCLRSSDCI | EGFCCARHFW | 
    250:
    TKICKPVLHQ | GEVCTKQRKK | GSHGLEIFQR | CDCAKGLSCK | VWKDATYSSK | 
    259:
    ARLHVCQKI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Dickkopf-2
    Cat.:
    E9039h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Dickkopf-2
    Cat.:
    E9039m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Dickkopf-2
    Cat.:
    U9039m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dickkopf-2
    Cat.:
    U9039h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Dickkopf-2
    Cat.:
    P9039Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dickkopf-2
    Cat.:
    P9039Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Dickkopf-2
    Monoclonal Antibody for Human Dickkopf-2
    Protein for Human Dickkopf-2
    Protein for Human Dickkopf-2

    R&D Technical Data

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fetal lung.
    2. 2.
      Tanaka S. , Sugimachi K. , Sugimachi K.
      Submitted (1999-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-146
      tissue: Brain.
      tissue: Testis.
    7. 7.
      Tate G. , Suzuki T. , Mitsuya T.
      Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-259
    8. 8.
      "Function and biological roles of the Dickkopf family of Wnt modulators."
      Niehrs C.
      Oncogene25:7469-7481(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW OF THE DKK FAMILY
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