Gene name:
DKK3 (UNQ258/PRO295;REIC) ;
Protein name:
Dickkopf-related protein 3 (Dickkopf-3;Dkk-3;hDkk-3) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with LRP5 and LRP6.
Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Subcellular Location:
Secreted
Protein Attributes:
50:
MQRLGATLLC | LLLAAAVPTA | PAPAPTATSA | PVKPGPALSY | PQEEATLNEM |
100:
FREVEELMED | TQHKLRSAVE | EMEAEEAAAK | ASSEVNLANL | PPSYHNETNT |
150:
DTKVGNNTIH | VHREIHKITN | NQTGQMVFSE | TVITSVGDEE | GRRSHECIID |
200:
EDCGPSMYCQ | FASFQYTCQP | CRGQRMLCTR | DSECCGDQLC | VWGHCTKMAT |
250:
RGSNGTICDN | QRDCQPGLCC | AFQRGLLFPV | CTPLPVEGEL | CHDPASRLLD |
300:
LITWELEPDG | ALDRCPCASG | LLCQPHSHSL | VYVCKPTFVG | SRDQDGEILL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
ELISA Kit for Human Dickkopf-3
ELISA Kit for Human Dickkopf-3
ELISA Kit for Human Dickkopf-3
CLIA Kit for Human Dickkopf-3
CLIA Kit for Human Dickkopf-3
CLIA Kit for Human Dickkopf-3
Polyclonal Antibody for Human Dickkopf-3
Polyclonal Antibody for Human Dickkopf-3
Polyclonal Antibody for Human Dickkopf-3
Monoclonal Antibody for Human Dickkopf-3
Monoclonal Antibody for Human Dickkopf-3
Monoclonal Antibody for Human Dickkopf-3
Protein for Human Dickkopf-3
Protein for Human Dickkopf-3
Protein for Human Dickkopf-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;POSSIBLE FUNCTION;GLYCOSYLATION;VARIANT GLY-335
tissue :
Fetal brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLY-335
tissue :
Corpus callosum .
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLY-335
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLY-335
tissue :
Kidney .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 22-36
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW OF THE DKK FAMILY
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS];SIGNAL SEQUENCE CLEAVAGE SITE;STRUCTURE OF CARBOHYDRATES
tissue :
Cerebrospinal fluid .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT THR-26 AND THR-28;IDENTIFICATION BY MASS SPECTROMETRY