DMBT1 ELISA Kit for Human(Homo sapiens) | EIAab.comDMBT1 ELISA Kit for Human(Homo sapiens)

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DMBT1 (Gene name),

Deleted in malignant brain tumors 1 protein (Protein name ), DMBT1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

DMBT1(GP340);

Protein name:

Deleted in malignant brain tumors 1 protein;

Alternative:

Hensin;Glycoprotein 340(Gp-340);Surfactant pulmonary-associated D-binding protein;Salivary agglutinin(SAG);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with LGALS3 (By similarity). Binds SFTPD and SPAR in a calcium-dependent manner. Binds to HIV-1 glycoprotein 120.

Function:

May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.

Subcellular Location:

Secreted Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae.

Protein Attributes:

Sequence length:

2413

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2413:

QLQTPPRREE | EPR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1755

UniGene:

Hs.279611

Pfam:

PF00431

String:

Q9UGM3

MIM:

137800

SMR:

Q9UGM3

Uniprot:

Q9UGM3

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ELISA Kit for Human Deleted in malignant brain tumors 1 protein

Cat.:

E15081h

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96T

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ELISA Kit for Human Deleted in malignant brain tumors 1 protein

MSDS:

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ELISA Kit for Human Deleted in malignant brain tumors 1 protein

MSDS:

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ELISA Kit for Human Deleted in malignant brain tumors 1 protein

MSDS:

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ELISA Kit for Human Deleted in malignant brain tumors 1 protein

MSDS:

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CLIA Kit for Human Deleted in malignant brain tumors 1 protein

Cat.:

U15081h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Deleted in malignant brain tumors 1 protein

MSDS:

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CLIA Kit for Human Deleted in malignant brain tumors 1 protein

MSDS:

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CLIA Kit for Human Deleted in malignant brain tumors 1 protein

MSDS:

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CLIA Kit for Human Deleted in malignant brain tumors 1 protein

MSDS:

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Polyclonal Antibody for Human Deleted in malignant brain tumors 1 protein

Monoclonal Antibody for Human Deleted in malignant brain tumors 1 protein

Protein for Human Deleted in malignant brain tumors 1 protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"DMBT1, a new member of the SRCR superfamily on chromosome 10q25.3-q26.1 is deleted in malignant brain tumours."
Mollenhauer J. , Wiemann S. , Scheurlen W. , Korn B. , Hayashi Y. , Wilgenbus K.K. , von Deimling A. , Poustka A.
Nat. Genet.17:32-39(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION AS A TUMOR SUPPRESSOR;TISSUE SPECIFICITY;VARIANTS THR-42 AND ALA-60
tissue: Lung.
2.

"Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D."
Holmskov U. , Mollenhauer J. , Madsen J. , Vitved L. , Gronlund J. , Tornoe I. , Kliem A. , Reid K.B.M. , Poustka A. , Skjodt K.
Proc. Natl. Acad. Sci. U.S.A.96:10794-10799(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION IN MUCOSAL AND CELLULAR IMMUNE DEFENSE;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;VARIANTS THR-42; LEU-54; ALA-60; MET-649; MET-780 AND SER-856
tissue: Trachea.
3.

"The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability."
Mollenhauer J. , Holmskov U. , Wiemann S. , Krebs I. , Herbertz S. , Madsen J. , Kioschis P. , Coy J.F. , Poustka A.
Oncogene18:6233-6240(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 3);ALTERNATIVE SPLICING;VARIANTS THR-42; LEU-54; ALA-60; LEU-337 AND SER-856
tissue: Lung.
4.

"Expression of the DMBT1 gene is frequently suppressed in human lung cancer."
Takeshita H. , Sato M. , Shiwaku H.O. , Semba S. , Sakurada A. , Hoshi M. , Hayashi Y. , Tagawa Y. , Ayabe H. , Horii A.
Jpn. J. Cancer Res.90:903-908(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];INVOLVEMENT IN LUNG CARCINOGENESIS;VARIANTS THR-42; LEU-54 AND SER-856
5.

"Deleted in malignant brain tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer."
Mollenhauer J. , Herbertz S. , Helmke B. , Kollender G. , Krebs I. , Madsen J. , Holmskov U. , Sorger K. , Schmitt L. , Wiemann S. , Otto H.F. , Grone H.-J. , Poustka A.
Cancer Res.61:8880-8886(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION IN EPITHELIAL DIFFERENTIATION;TISSUE SPECIFICITY;ALTERNATIVE SPLICING;INVOLVEMENT IN ESOPHAGEAL CARCINOMAS;VARIANT SER-856
tissue: Small intestine.
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9)
tissue: Trachea.
7.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8);VARIANT LEU-54
9.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-1480 (ISOFORM 4)
tissue: Brain.
10.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1689-2413 (ISOFORM 5)
tissue: Small intestine.
11.

"Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule."
Holmskov U. , Lawson P. , Teisner B. , Tornoe I. , Willis A.C. , Morgan C. , Koch C. , Reid K.B.
J. Biol. Chem.272:13743-13749(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SFTPD
12.

"Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner."
Tino M.J. , Wright J.R.
Am. J. Respir. Cell Mol. Biol.20:759-768(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPAR
13.

"Lack of DMBT1 expression in oesophageal, gastric and colon cancers."
Mori M. , Shiraishi T. , Tanaka S. , Yamagata M. , Mafune K. , Tanaka Y. , Ueo H. , Barnard G.F. , Sugimachi K.
Br. J. Cancer79:211-213(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ESOPHAGEAL; GASTRIC AND COLON CANCERS
14.

"DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer."
Mollenhauer J. , Herbertz S. , Holmskov U. , Tolnay M. , Krebs I. , Merlo A. , Schroder H.D. , Maier D. , Breitling F. , Wiemann S. , Groene H.-J. , Poustka A.
Cancer Res.60:1704-1710(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
15.

"Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340."
Prakobphol A. , Xu F. , Hoang V.M. , Larsson T. , Bergstrom J. , Johansson I. , Fraengsmyr L. , Holmskov U. , Leffler H. , Nilsson C. , Boren T. , Wright J.R. , Stroemberg N. , Fisher S.J.
J. Biol. Chem.275:39860-39866(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION
tissue: Saliva.
16.

"Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains."
Bikker F.J. , Ligtenberg A.J.M. , End C. , Renner M. , Blaich S. , Lyer S. , Wittig R. , van't Hof W. , Veerman E.C.I. , Nazmi K. , de Blieck-Hogervorst J.M.A. , Kioschis P. , Nieuw Amerongen A.V. , Poustka A. , Mollenhauer J.
J. Biol. Chem.279:47699-47703(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BACTERIAL-BINDING DOMAIN
17.

"The N-terminal SRCR-SID domain of gp-340 interacts with HIV type 1 gp120 sequences and inhibits viral infection."
Wu Z. , Lee S. , Abrams W. , Weissman D. , Malamud D.
AIDS Res. Hum. Retroviruses22:508-515(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HIV-1 GP120;TISSUE SPECIFICITY
18.

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
Ramachandran P. , Boontheung P. , Xie Y. , Sondej M. , Wong D.T. , Loo J.A.
J. Proteome Res.5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1712; ASN-1889 AND ASN-2188
tissue: Saliva.
19.

"DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease."
Renner M. , Bergmann G. , Krebs I. , End C. , Lyer S. , Hilberg F. , Helmke B. , Gassler N. , Autschbach F. , Bikker F. , Strobel-Freidekind O. , Gronert-Sum S. , Benner A. , Blaich S. , Wittig R. , Hudler M. , Ligtenberg A.J. , Madsen J. , more...
Gastroenterology133:1499-1509(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
20.

"Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion."
Rosenstiel P. , Sina C. , End C. , Renner M. , Lyer S. , Till A. , Hellmig S. , Nikolaus S. , Foelsch U.R. , Helmke B. , Autschbach F. , Schirmacher P. , Kioschis P. , Hafner M. , Poustka A. , Mollenhauer J. , Schreiber S.
J. Immunol.178:8203-8211(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION
21.

"gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission."
Stoddard E. , Cannon G. , Ni H. , Kariko K. , Capodici J. , Malamud D. , Weissman D.
J. Immunol.179:3126-3132(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
22.

"A common binding motif for various bacteria of the bacteria-binding peptide SRCRP2 of DMBT1/gp-340/salivary agglutinin."
Leito J.T.D. , Ligtenberg A.J.M. , Nazmi K. , de Blieck-Hogervorst J.M.A. , Veerman E.C.I. , Nieuw Amerongen A.V.
Biol. Chem.389:1193-1200(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BACTERIAL-BINDING DOMAIN
23.

"DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands."
End C. , Bikker F. , Renner M. , Bergmann G. , Lyer S. , Blaich S. , Hudler M. , Helmke B. , Gassler N. , Autschbach F. , Ligtenberg A.J.M. , Benner A. , Holmskov U. , Schirmacher P. , Nieuw Amerongen A.V. , Rosenstiel P. , Sina C. , Franke A. , more...
Eur. J. Immunol.39:833-842(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
24.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer."
Mollenhauer J. , Mueller H. , Kollender G. , Lyer S. , Diedrichs L. , Helmke B. , Holmskov U. , Ligtenberg T. , Herbertz S. , Krebs I. , Madsen J. , Bikker F. , Schmitt L. , Wiemann S. , Scheurlen W. , Otto H.F. , von Deimling A. , Poustka A.
Genes Chromosomes Cancer35:242-255(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-42; TRP-52; LEU-54; GLU-162; ASP-322; SER-357; SER-546; PRO-1095; THR-1102; TRP-1434; SER-1732 AND MET-2255
26.

"Rare mutations of the DMBT1 gene in human astrocytic gliomas."
Mueller W. , Mollenhauer J. , Stockhammer F. , Poustka A. , von Deimling A.
Oncogene21:5956-5959(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-42; TRP-52; LEU-54; ALA-60; LEU-65; LEU-337; SER-357; GLY-364; MET-649; MET-780; TYR-1084; THR-1169; TRP-1176; MET-1545; SER-1732 AND PRO-1961

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