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Index > Protein center > DNASE1(Gene name) > Human
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  • DNASE1 (Gene name),
  • Deoxyribonuclease-1 (Protein name ),  DNAS1_HUMAN from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
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  • Citations  (1)
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  • Gene name:
    DNASE1(DNL1;DRNI);
    Protein name:
    Deoxyribonuclease-1;
    Alternative:
    Deoxyribonuclease I(DNase I);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization.
    Subcellular Location:
    Secreted Nucleus envelope Secretory protein, stored in zymogen granules and found in the nuclear envelope.
    Protein Attributes:
    Sequence length:
    282
    Sequence:
    50:
    MRGMKLLGAL | LALAALLQGA | VSLKIAAFNI | QTFGETKMSN | ATLVSYIVQI | 
    100:
    LSRYDIALVQ | EVRDSHLTAV | GKLLDNLNQD | APDTYHYVVS | EPLGRNSYKE | 
    150:
    RYLFVYRPDQ | VSAVDSYYYD | DGCEPCGNDT | FNREPAIVRF | FSRFTEVREF | 
    200:
    AIVPLHAAPG | DAVAEIDALY | DVYLDVQEKW | GLEDVMLMGD | FNAGCSYVRP | 
    250:
    SQWSSIRLWT | SPTFQWLIPD | SADTTATPTH | CAYDRIVVAG | MLLRGAVVPD | 
    282:
    SALPFNFQAA | YGLSDQLAQA | ISDHYPVEVM | LK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    KEGG:
    UniGene:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Deoxyribonuclease-1
    Cat.:
    E1127h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Deoxyribonuclease-1
    Cat.:
    E1127r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Deoxyribonuclease-1
    Cat.:
    E1127m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Deoxyribonuclease-1
    Cat.:
    E1127p
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Deoxyribonuclease-1
    Cat.:
    E1127d
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Deoxyribonuclease-1
    Cat.:
    E1127c
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Deoxyribonuclease-1
    MSDS:
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    ELISA Kit for Human Deoxyribonuclease-1
    Cat.:
    E1127b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Deoxyribonuclease-1
    Cat.:
    U1127b
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Deoxyribonuclease-1
    Cat.:
    U1127r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Deoxyribonuclease-1
    Cat.:
    U1127h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Deoxyribonuclease-1
    Cat.:
    U1127d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Deoxyribonuclease-1
    Cat.:
    U1127p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Deoxyribonuclease-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Deoxyribonuclease-1
    Cat.:
    U1127m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Deoxyribonuclease-1
    Cat.:
    U1127c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Deoxyribonuclease-1
    Cat.:
    P1127Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Deoxyribonuclease-1
    Polyclonal Antibody for Human Deoxyribonuclease-1
    Polyclonal Antibody for Human Deoxyribonuclease-1
    Cat.:
    P1127Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Deoxyribonuclease-1
    Polyclonal Antibody for Human Deoxyribonuclease-1
    Cat.:
    P1127Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Deoxyribonuclease-1
    Polyclonal Antibody for Human Deoxyribonuclease-1
    Monoclonal Antibody for Human Deoxyribonuclease-1
    Monoclonal Antibody for Human Deoxyribonuclease-1
    Monoclonal Antibody for Human Deoxyribonuclease-1
    Monoclonal Antibody for Human Deoxyribonuclease-1
    Monoclonal Antibody for Human Deoxyribonuclease-1
    Monoclonal Antibody for Human Deoxyribonuclease-1
    Monoclonal Antibody for Human Deoxyribonuclease-1
    Monoclonal Antibody for Human Deoxyribonuclease-1
    Protein for Human Deoxyribonuclease-1
    Protein for Human Deoxyribonuclease-1
    Protein for Human Deoxyribonuclease-1
    Protein for Human Deoxyribonuclease-1
    Protein for Human Deoxyribonuclease-1
    Protein for Human Deoxyribonuclease-1
    Protein for Human Deoxyribonuclease-1
    Protein for Human Deoxyribonuclease-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum."
      Shak S. , Capon D.J. , Hellmiss R. , Marsters S.A. , Baker C.L.
      Proc. Natl. Acad. Sci. U.S.A.87:9188-9192(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Structure of the human deoxyribonuclease I (DNase I) gene: identification of the nucleotide substitution that generates its classical genetic polymorphism."
      Yasuda T. , Kishi K. , Yanagawa Y. , Yoshida A.
      Ann. Hum. Genet.59:1-15(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLN-244
      tissue: Placenta.
    3. 3.
      "DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis."
      Oliveri M. , Daga A. , Cantoni C. , Lunardi C. , Millo R. , Puccetti A.
      Eur. J. Immunol.31:743-751(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation."
      Kominato Y. , Ueki M. , Iida R. , Kawai Y. , Nakajima T. , Makita C. , Itoi M. , Tajima Y. , Kishi K. , Yasuda T.
      FEBS J.273:3094-3105(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Pancreas.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Small intestine.
    6. 6.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
    9. 9.
      "A human urine-derived interleukin 1 inhibitor. Homology with deoxyribonuclease I."
      Rosenstreich D.L. , Tu J.H. , Kinkade P.R. , Maurer-Fogy I. , Kahn J. , Barton R.W. , Farina P.R.
      J. Exp. Med.168:1767-1779(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-45 AND 73-95
      tissue: Urine.
    10. 10.
      "Human genetically polymorphic deoxyribonuclease: purification, characterization, and multiplicity of urine deoxyribonuclease I."
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      Nat. Genet.28:313-314(2001) [PubMed] [Europe PMC] [Abstract]
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      Ann. Hum. Genet.59:139-147(1995) [PubMed] [Europe PMC] [Abstract]
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      Yasuda T. , Nadano D. , Takeshita H. , Tenjo E. , Sawazaki K. , Ootani M. , Kishi K.
      FEBS Lett.359:211-214(1995) [PubMed] [Europe PMC] [Abstract]
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      "A new allele, DNASE1*6, of human deoxyribonuclease I polymorphism encodes an Arg to Cys substitution responsible for its instability."
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