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Index > Protein center > DPP4(Gene name) > Human
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  • DPP4 (Gene name),
  • Dipeptidyl peptidase 4 (Protein name ),  DPP4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DPP4(ADCP2;CD26);
    Protein name:
    Dipeptidyl peptidase 4;
    Alternative:
    Adenosine deaminase complexing protein 2(ADCP-2);ADABP;T-cell activation antigen CD26;Dipeptidyl peptidase IV(DPP IV);TP103;
    CD:
    CD26;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Homodimer or heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3.
    Function:
    Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein Apical cell membrane Single-pass type II membrane protein Cell projection invadopodium membrane Single-pass type II membrane protein Cell projection lamellipodium membrane Single-pass type II membrane protein Cell junction Membrane raft Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface.
    Protein Attributes:
    Sequence length:
    766
    Sequence:
    50:
    MKTPWKVLLG | LLGAAALVTI | ITVPVVLLNK | GTDDATADSR | KTYTLTDYLK | 
    100:
    NTYRLKLYSL | RWISDHEYLY | KQENNILVFN | AEYGNSSVFL | ENSTFDEFGH | 
    150:
    SINDYSISPD | GQFILLEYNY | VKQWRHSYTA | SYDIYDLNKR | QLITEERIPN | 
    200:
    NTQWVTWSPV | GHKLAYVWNN | DIYVKIEPNL | PSYRITWTGK | EDIIYNGITD | 
    250:
    WVYEEEVFSA | YSALWWSPNG | TFLAYAQFND | TEVPLIEYSF | YSDESLQYPK | 
    300:
    TVRVPYPKAG | AVNPTVKFFV | VNTDSLSSVT | NATSIQITAP | ASMLIGDHYL | 
    350:
    CDVTWATQER | ISLQWLRRIQ | NYSVMDICDY | DESSGRWNCL | VARQHIEMST | 
    400:
    TGWVGRFRPS | EPHFTLDGNS | FYKIISNEEG | YRHICYFQID | KKDCTFITKG | 
    450:
    TWEVIGIEAL | TSDYLYYISN | EYKGMPGGRN | LYKIQLSDYT | KVTCLSCELN | 
    500:
    PERCQYYSVS | FSKEAKYYQL | RCSGPGLPLY | TLHSSVNDKG | LRVLEDNSAL | 
    550:
    DKMLQNVQMP | SKKLDFIILN | ETKFWYQMIL | PPHFDKSKKY | PLLLDVYAGP | 
    600:
    CSQKADTVFR | LNWATYLAST | ENIIVASFDG | RGSGYQGDKI | MHAINRRLGT | 
    650:
    FEVEDQIEAA | RQFSKMGFVD | NKRIAIWGWS | YGGYVTSMVL | GSGSGVFKCG | 
    700:
    IAVAPVSRWE | YYDSVYTERY | MGLPTPEDNL | DHYRNSTVMS | RAENFKQVEY | 
    750:
    LLIHGTADDN | VHFQQSAQIS | KALVDVGVDF | QAMWYTDEDH | GIASSTAHQH | 
    766:
    IYTHMSHFIK | QCFSLP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    Pfam:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Dipeptidyl peptidase 4
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    E0884h
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    ELISA Kit for Human Dipeptidyl peptidase 4
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    E0884m
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    ELISA Kit for Human Dipeptidyl peptidase 4
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    E0884r
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    ELISA Kit for Human Dipeptidyl peptidase 4
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    E0884p
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    ELISA Kit for Human Dipeptidyl peptidase 4
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    E0884b
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    96T
    CLIA Kit for Human Dipeptidyl peptidase 4
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    U0884m
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    96T
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    CLIA Kit for Human Dipeptidyl peptidase 4
    Cat.:
    U0884b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dipeptidyl peptidase 4
    Cat.:
    U0884h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dipeptidyl peptidase 4
    Cat.:
    U0884p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dipeptidyl peptidase 4
    Cat.:
    U0884r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Dipeptidyl peptidase 4
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    P0884Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dipeptidyl peptidase 4
    Cat.:
    P0884Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dipeptidyl peptidase 4
    Polyclonal Antibody for Human Dipeptidyl peptidase 4
    Cat.:
    P0884Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dipeptidyl peptidase 4
    Monoclonal Antibody for Human Dipeptidyl peptidase 4
    Monoclonal Antibody for Human Dipeptidyl peptidase 4
    Monoclonal Antibody for Human Dipeptidyl peptidase 4
    Monoclonal Antibody for Human Dipeptidyl peptidase 4
    Monoclonal Antibody for Human Dipeptidyl peptidase 4
    Protein for Human Dipeptidyl peptidase 4
    Protein for Human Dipeptidyl peptidase 4
    Protein for Human Dipeptidyl peptidase 4
    Protein for Human Dipeptidyl peptidase 4
    Protein for Human Dipeptidyl peptidase 4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface."
      Misumi Y. , Hayashi Y. , Arakawa F. , Ikehara Y.
      Biochim. Biophys. Acta1131:333-336(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      "Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation."
      Darmoul D. , Lacasa M. , Baricault L. , Marguet D. , Sapin C. , Trotot P. , Barbat A.
      J. Biol. Chem.267:4824-4833(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Colon.
    3. 3.
      "Cloning and functional expression of the T cell activation antigen CD26."
      Tanaka T. , Camerini D. , Seed B. , Torimoto Y. , Dang N.H. , Kameoka J. , Dahlberg H.N. , Schlossman S.F. , Morimoto C.
      J. Immunol.149:481-486(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Peripheral blood.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    5. 5.
      "Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene."
      Abbott C.A. , Baker E. , Sutherland G.R. , McCaughan G.W.
      Immunogenetics40:331-338(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    6. 6.
      "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
      Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
      tissue: Uterus.
    10. 10.
      "Isolation of a cDNA probe for the human intestinal dipeptidylpeptidase IV and assignment of the gene locus DPP4 to chromosome 2."
      Darmoul D. , Lacasa M. , Chantret I. , Swallow D. , Trugnan G.
      Ann. Hum. Genet.54:191-197(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 545-766
      tissue: Colon.
    11. 11.
      "Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter."
      Boehm S.K. , Gum J.R. Jr. , Erickson R.H. , Hicks J.W. , Kim Y.S.
      Biochem. J.311:835-843(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31
    12. 12.
      "Expression of sucrase-isomaltase and dipeptidylpeptidase IV in human small intestine and colon."
      Gorvel J.P. , Ferrero A. , Chambraud L. , Rigal A. , Bonicel J. , Maroux S.
      Gastroenterology101:618-625(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-22;TISSUE SPECIFICITY
    13. 13.
      "Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides."
      Durinx C. , Lambeir A.M. , Bosmans E. , Falmagne J.B. , Berghmans R. , Haemers A. , Scharpe S. , De Meester I.
      Eur. J. Biochem.267:5608-5613(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-34 AND 39-43;FUNCTION;INTERACTION WITH ADA;SUBCELLULAR LOCATION
    14. 14.
      "The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26."
      Davoodi J. , Kelly J. , Gendron N.H. , MacKenzie A.E.
      Proteomics7:2300-2310(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 659-669;FUNCTION;ENZYME REGULATION;INTERACTION WITH GPC3;IDENTIFICATION BY MASS SPECTROMETRY
    15. 15.
      "A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase."
      Morrison M.E. , Vijayasaradhi S. , Engelstein D. , Albino A.P. , Houghton A.N.
      J. Exp. Med.177:1135-1143(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
      tissue: Kidney.
    16. 16.
      "Direct association of adenosine deaminase with a T cell activation antigen, CD26."
      Kameoka J. , Tanaka T. , Nojima Y. , Schlossman S.F. , Morimoto C.
      Science261:466-469(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADA;SUBCELLULAR LOCATION
    17. 17.
      "Binding of adenosine deaminase to the lymphocyte surface via CD26."
      De Meester I. , Vanham G. , Kestens L. , Vanhoof G. , Bosmans E. , Gigase P. , Scharpe S.
      Eur. J. Immunol.24:566-570(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADA
    18. 18.
      "The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site."
      Loster K. , Zeilinger K. , Schuppan D. , Reutter W.
      Biochem. Biophys. Res. Commun.217:341-348(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH COLLAGEN
    19. 19.
      "Interleukin-12 enhances CD26 expression and dipeptidyl peptidase IV function on human activated lymphocytes."
      Cordero O.J. , Salgado F.J. , Vinuela J.E. , Nogueira M.
      Immunobiology197:522-533(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    20. 20.
      "Two highly conserved glutamic acid residues in the predicted beta propeller domain of dipeptidyl peptidase IV are required for its enzyme activity."
      Abbott C.A. , McCaughan G.W. , Gorrell M.D.
      FEBS Lett.458:278-284(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF GLU-205 AND GLU-206
    21. 21.
      "Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts."
      Park J.E. , Lenter M.C. , Zimmermann R.N. , Garin-Chesa P. , Old L.J. , Rettig W.J.
      J. Biol. Chem.274:36505-36512(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY
    22. 22.
      "Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer."
      Cordero O.J. , Ayude D. , Nogueira M. , Rodriguez-Berrocal F.J. , de la Cadena M.P.
      Br. J. Cancer83:1139-1146(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH CANCER
    23. 23.
      "Mechanisms of CD26/dipeptidyl peptidase IV cytokine-dependent regulation on human activated lymphocytes."
      Salgado F.J. , Vela E. , Martin M. , Franco R. , Nogueira M. , Cordero O.J.
      Cytokine12:1136-1141(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    24. 24.
      "Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation."
      Ikushima H. , Munakata Y. , Ishii T. , Iwata S. , Terashima M. , Tanaka H. , Schlossman S.F. , Morimoto C.
      Proc. Natl. Acad. Sci. U.S.A.97:8439-8444(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IGF2R;GLYCOSYLATION;PHOSPHORYLATION;SUBCELLULAR LOCATION
    25. 25.
      "Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction."
      Gines S. , Marino M. , Mallol J. , Canela E.I. , Morimoto C. , Callebaut C. , Hovanessian A. , Casado V. , Lluis C. , Franco R.
      Biochem. J.361:203-209(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    26. 26.
      "Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains."
      Alfalah M. , Jacob R. , Naim H.Y.
      J. Biol. Chem.277:10683-10690(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;SUBCELLULAR LOCATION
    27. 27.
      "A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation."
      Salgado F.J. , Lojo J. , Alonso-Lebrero J.L. , Lluis C. , Franco R. , Cordero O.J. , Nogueira M.
      J. Biol. Chem.278:24849-24857(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRC;INDUCTION;SUBCELLULAR LOCATION
    28. 28.
      "One site mutation disrupts dimer formation in human DPP-IV proteins."
      Chien C.H. , Huang L.H. , Chou C.Y. , Chen Y.S. , Han Y.S. , Chang G.G. , Liang P.H. , Chen X.
      J. Biol. Chem.279:52338-52345(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMODIMERIZATION;MUTAGENESIS OF HIS-750
    29. 29.
      "N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding."
      Aertgeerts K. , Ye S. , Shi L. , Prasad S.G. , Witmer D. , Chi E. , Sang B.C. , Wijnands R.A. , Webb D.R. , Swanson R.V.
      Protein Sci.13:145-154(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ADA;MUTAGENESIS OF ASN-85; ASN-92; ASN-150; ASN-219; ASN-229; ASN-281; ASN-321; ASN-520 AND ASN-685
    30. 30.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-520 AND ASN-685
      tissue: Plasma.
    31. 31.
      "The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices."
      Ghersi G. , Zhao Q. , Salamone M. , Yeh Y. , Zucker S. , Chen W.T.
      Cancer Res.66:4652-4661(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HETERODIMERIZATION;INDUCTION;SUBCELLULAR LOCATION
    32. 32.
      "Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1."
      Ohnuma K. , Uchiyama M. , Yamochi T. , Nishibashi K. , Hosono O. , Takahashi N. , Kina S. , Tanaka H. , Lin X. , Dang N.H. , Morimoto C.
      J. Biol. Chem.282:10117-10131(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A MEMBRANE RAFT COMPLEX;HOMODIMERIZATION;INTERACTION WITH CARD11 AND CAV1;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-750
    33. 33.
      "Lymphatic-specific expression of dipeptidyl peptidase IV and its dual role in lymphatic endothelial function."
      Shin J.W. , Jurisic G. , Detmar M.
      Exp. Cell Res.314:3048-3056(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;TISSUE SPECIFICITY
    34. 34.
      "On the origin of serum CD26 and its altered concentration in cancer patients."
      Cordero O.J. , Salgado F.J. , Nogueira M.
      Cancer Immunol. Immunother.58:1723-1747(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    35. 35.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-92; ASN-150; ASN-520 AND ASN-685
      tissue: Liver.
    36. 36.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    37. 37.
      "Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC."
      Raj V.S. , Mou H. , Smits S.L. , Dekkers D.H. , Muller M.A. , Dijkman R. , Muth D. , Demmers J.A. , Zaki A. , Fouchier R.A. , Thiel V. , Drosten C. , Rottier P.J. , Osterhaus A.D. , Bosch B.J. , Haagmans B.L.
      Nature495:251-254(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN CORONAVIRUS-EMC SPIKE PROTEIN
    38. 38.
      "High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine."
      Oefner C. , D'Arcy A. , Mac Sweeney A. , Pierau S. , Gardiner R. , Dale G.E.
      Acta Crystallogr. D59:1206-1212(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 38-766 IN COMPLEX WITH INHIBITOR;HOMODIMERIZATION
    39. 39.
      "The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold."
      Hiramatsu H. , Kyono K. , Higashiyama Y. , Fukushima C. , Shima H. , Sugiyama S. , Inaka K. , Yamamoto A. , Shimizu R.
      Biochem. Biophys. Res. Commun.302:849-854(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 35-771;HOMODIMERIZATION;GLYCOSYLATION AT ASN-85; ASN-219; ASN-229; ASN-281 AND ASN-321;DISULFIDE BONDS
    40. 40.
      "Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog."
      Rasmussen H.B. , Branner S. , Wiberg F.C. , Wagtmann N.
      Nat. Struct. Biol.10:19-25(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-766;HOMODIMERIZATION;GLYCOSYLATION AT ASN-85; ASN-150; ASN-219; ASN-229; ASN-281; ASN-321 AND ASN-520;DISULFIDE BONDS
    41. 41.
      "Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV."
      Thoma R. , Loeffler B. , Stihle M. , Huber W. , Ruf A. , Hennig M.
      Structure11:947-959(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-766;HOMODIMERIZATION;GLYCOSYLATION AT ASN-85; ASN-150; ASN-229 AND ASN-281;DISULFIDE BONDS
    42. 42.
      "Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors."
      Meng W. , Brigance R.P. , Chao H.J. , Fura A. , Harrity T. , Marcinkeviciene J. , O'Connor S.P. , Tamura J.K. , Xie D. , Zhang Y. , Klei H.E. , Kish K. , Weigelt C.A. , Turdi H. , Wang A. , Zahler R. , Kirby M.S. , Hamann L.G.
      J. Med. Chem.53:5620-5628(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.34 ANGSTROMS) OF 39-766;GLYCOSYLATION AT ASN-85; ASN-92; ASN-150; ASN-219; ASN-229 AND ASN-520
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