Gene name:
DPP4 (ADCP2;CD26) ;
Protein name:
Dipeptidyl peptidase 4 ;
Alternative:
Adenosine deaminase complexing protein 2 (ADCP-2) ;ADABP ;T-cell activation antigen CD26 ;Dipeptidyl peptidase IV (DPP IV) ;TP103 ;
CD:
CD26 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Monomer. Homodimer or heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3.
Function:
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
Apical cell membrane
Single-pass type II membrane protein
Cell projection
invadopodium membrane
Single-pass type II membrane protein
Cell projection
lamellipodium membrane
Single-pass type II membrane protein
Cell junction
Membrane raft
Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface.
Protein Attributes:
50:
MKTPWKVLLG | LLGAAALVTI | ITVPVVLLNK | GTDDATADSR | KTYTLTDYLK |
100:
NTYRLKLYSL | RWISDHEYLY | KQENNILVFN | AEYGNSSVFL | ENSTFDEFGH |
150:
SINDYSISPD | GQFILLEYNY | VKQWRHSYTA | SYDIYDLNKR | QLITEERIPN |
200:
NTQWVTWSPV | GHKLAYVWNN | DIYVKIEPNL | PSYRITWTGK | EDIIYNGITD |
250:
WVYEEEVFSA | YSALWWSPNG | TFLAYAQFND | TEVPLIEYSF | YSDESLQYPK |
300:
TVRVPYPKAG | AVNPTVKFFV | VNTDSLSSVT | NATSIQITAP | ASMLIGDHYL |
350:
CDVTWATQER | ISLQWLRRIQ | NYSVMDICDY | DESSGRWNCL | VARQHIEMST |
400:
TGWVGRFRPS | EPHFTLDGNS | FYKIISNEEG | YRHICYFQID | KKDCTFITKG |
450:
TWEVIGIEAL | TSDYLYYISN | EYKGMPGGRN | LYKIQLSDYT | KVTCLSCELN |
500:
PERCQYYSVS | FSKEAKYYQL | RCSGPGLPLY | TLHSSVNDKG | LRVLEDNSAL |
550:
DKMLQNVQMP | SKKLDFIILN | ETKFWYQMIL | PPHFDKSKKY | PLLLDVYAGP |
600:
CSQKADTVFR | LNWATYLAST | ENIIVASFDG | RGSGYQGDKI | MHAINRRLGT |
650:
FEVEDQIEAA | RQFSKMGFVD | NKRIAIWGWS | YGGYVTSMVL | GSGSGVFKCG |
700:
IAVAPVSRWE | YYDSVYTERY | MGLPTPEDNL | DHYRNSTVMS | RAENFKQVEY |
750:
LLIHGTADDN | VHFQQSAQIS | KALVDVGVDF | QAMWYTDEDH | GIASSTAHQH |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
ELISA Kit for Human Dipeptidyl peptidase 4
ELISA Kit for Human Dipeptidyl peptidase 4
ELISA Kit for Human Dipeptidyl peptidase 4
ELISA Kit for Human Dipeptidyl peptidase 4
ELISA Kit for Human Dipeptidyl peptidase 4
CLIA Kit for Human Dipeptidyl peptidase 4
CLIA Kit for Human Dipeptidyl peptidase 4
CLIA Kit for Human Dipeptidyl peptidase 4
CLIA Kit for Human Dipeptidyl peptidase 4
CLIA Kit for Human Dipeptidyl peptidase 4
Polyclonal Antibody for Human Dipeptidyl peptidase 4
Polyclonal Antibody for Human Dipeptidyl peptidase 4
Polyclonal Antibody for Human Dipeptidyl peptidase 4
Polyclonal Antibody for Human Dipeptidyl peptidase 4
Polyclonal Antibody for Human Dipeptidyl peptidase 4
Monoclonal Antibody for Human Dipeptidyl peptidase 4
Monoclonal Antibody for Human Dipeptidyl peptidase 4
Monoclonal Antibody for Human Dipeptidyl peptidase 4
Monoclonal Antibody for Human Dipeptidyl peptidase 4
Monoclonal Antibody for Human Dipeptidyl peptidase 4
Protein for Human Dipeptidyl peptidase 4
Protein for Human Dipeptidyl peptidase 4
Protein for Human Dipeptidyl peptidase 4
Protein for Human Dipeptidyl peptidase 4
Protein for Human Dipeptidyl peptidase 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Colon .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Peripheral blood .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Prostate .
tissue :
Uterus .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 545-766
tissue :
Colon .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1-22;TISSUE SPECIFICITY
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 29-34 AND 39-43;FUNCTION;INTERACTION WITH ADA;SUBCELLULAR LOCATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 659-669;FUNCTION;ENZYME REGULATION;INTERACTION WITH GPC3;IDENTIFICATION BY MASS SPECTROMETRY
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE
tissue :
Kidney .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ADA;SUBCELLULAR LOCATION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ADA
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION WITH COLLAGEN
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF GLU-205 AND GLU-206
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION WITH CANCER
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH IGF2R;GLYCOSYLATION;PHOSPHORYLATION;SUBCELLULAR LOCATION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION;SUBCELLULAR LOCATION
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PTPRC;INDUCTION;SUBCELLULAR LOCATION
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : HOMODIMERIZATION;MUTAGENESIS OF HIS-750
29.
"N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding."
Aertgeerts K.
,
Ye S.
,
Shi L.
,
Prasad S.G.
,
Witmer D.
,
Chi E.
,
Sang B.C.
,
Wijnands R.A.
,
Webb D.R.
,
Swanson R.V.
Protein Sci.13:145-154(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ADA;MUTAGENESIS OF ASN-85; ASN-92; ASN-150; ASN-219; ASN-229; ASN-281; ASN-321; ASN-520 AND ASN-685
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-520 AND ASN-685
tissue :
Plasma .
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;HETERODIMERIZATION;INDUCTION;SUBCELLULAR LOCATION
32.
"Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1."
Ohnuma K.
,
Uchiyama M.
,
Yamochi T.
,
Nishibashi K.
,
Hosono O.
,
Takahashi N.
,
Kina S.
,
Tanaka H.
,
Lin X.
,
Dang N.H.
,
Morimoto C.
J. Biol. Chem.282:10117-10131(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN A MEMBRANE RAFT COMPLEX;HOMODIMERIZATION;INTERACTION WITH CARD11 AND CAV1;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-750
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ENZYME REGULATION;TISSUE SPECIFICITY
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-92; ASN-150; ASN-520 AND ASN-685
tissue :
Liver .
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
37.
"Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC."
Raj V.S.
,
Mou H.
,
Smits S.L.
,
Dekkers D.H.
,
Muller M.A.
,
Dijkman R.
,
Muth D.
,
Demmers J.A.
,
Zaki A.
,
Fouchier R.A.
,
Thiel V.
,
Drosten C.
,
Rottier P.J.
,
Osterhaus A.D.
,
Bosch B.J.
,
Haagmans B.L.
Nature495:251-254(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HUMAN CORONAVIRUS-EMC SPIKE PROTEIN
38.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 38-766 IN COMPLEX WITH INHIBITOR;HOMODIMERIZATION
39.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 35-771;HOMODIMERIZATION;GLYCOSYLATION AT ASN-85; ASN-219; ASN-229; ASN-281 AND ASN-321;DISULFIDE BONDS
40.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-766;HOMODIMERIZATION;GLYCOSYLATION AT ASN-85; ASN-150; ASN-219; ASN-229; ASN-281; ASN-321 AND ASN-520;DISULFIDE BONDS
41.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-766;HOMODIMERIZATION;GLYCOSYLATION AT ASN-85; ASN-150; ASN-229 AND ASN-281;DISULFIDE BONDS
42.
"Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors."
Meng W.
,
Brigance R.P.
,
Chao H.J.
,
Fura A.
,
Harrity T.
,
Marcinkeviciene J.
,
O'Connor S.P.
,
Tamura J.K.
,
Xie D.
,
Zhang Y.
,
Klei H.E.
,
Kish K.
,
Weigelt C.A.
,
Turdi H.
,
Wang A.
,
Zahler R.
,
Kirby M.S.
,
Hamann L.G.
J. Med. Chem.53:5620-5628(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.34 ANGSTROMS) OF 39-766;GLYCOSYLATION AT ASN-85; ASN-92; ASN-150; ASN-219; ASN-229 AND ASN-520