Protein name:
Dihydropyrimidine dehydrogenase [NADP+] (DHPDHase;DPD) ;
Alternative:
Dihydrouracil dehydrogenase ;Dihydrothymine dehydrogenase ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MAPVLSKDSA | DIESILALNP | RTQTHATLCS | TSAKKLDKKH | WKRNPDKNCF |
100:
NCEKLENNFD | DIKHTTLGER | GALREAMRCL | KCADAPCQKS | CPTNLDIKSF |
150:
ITSIANKNYY | GAAKMIFSDN | PLGLTCGMVC | PTSDLCVGGC | NLYATEEGPI |
200:
NIGGLQQFAT | EVFKAMSIPQ | IRNPSLPPPE | KMSEAYSAKI | ALFGAGPASI |
250:
SCASFLARLG | YSDITIFEKQ | EYVGGLSTSE | IPQFRLPYDV | VNFEIELMKD |
300:
LGVKIICGKS | LSVNEMTLST | LKEKGYKAAF | IGIGLPEPNK | DAIFQGLTQD |
350:
QGFYTSKDFL | PLVAKGSKAG | MCACHSPLPS | IRGVVIVLGA | GDTAFDCATS |
400:
ALRCGARRVF | IVFRKGFVNI | RAVPEEMELA | KEEKCEFLPF | LSPRKVIVKG |
450:
GRIVAMQFVR | TEQDETGKWN | EDEDQMVHLK | ADVVISAFGS | VLSDPKVKEA |
500:
LSPIKFNRWG | LPEVDPETMQ | TSEAWVFAGG | DVVGLANTTV | ESVNDGKQAS |
550:
WYIHKYVQSQ | YGASVSAKPE | LPLFYTPIDL | VDISVEMAGL | KFINPFGLAS |
600:
ATPATSTSMI | RRAFEAGWGF | ALTKTFSLDK | DIVTNVSPRI | IRGTTSGPMY |
650:
GPGQSSFLNI | ELISEKTAAY | WCQSVTELKA | DFPDNIVIAS | IMCSYNKNDW |
700:
TELAKKSEDS | GADALELNLS | CPHGMGERGM | GLACGQDPEL | VRNICRWVRQ |
750:
AVQIPFFAKL | TPNVTDIVSI | ARAAKEGGAN | GVTATNTVSG | LMGLKSDGTP |
800:
WPAVGIAKRT | TYGGVSGTAI | RPIALRAVTS | IARALPGFPI | LATGGIDSAE |
850:
SGLQFLHSGA | SVLQVCSAIQ | NQDFTVIEDY | CTGLKALLYL | KSIEELQDWD |
900:
GQSPATVSHQ | KGKPVPRIAE | LMDKKLPSFG | PYLEQRKKII | AENKIRLKEQ |
950:
NVAFSPLKRN | CFIPKRPIPT | IKDVIGKALQ | YLGTFGELSN | VEQVVAMIDE |
1000:
EMCINCGKCY | MTCNDSGYQA | IQFDPETHLP | TITDTCTGCT | LCLSVCPIVD |
1025:
CIKMVSRTTP | YEPKRGVPLS | VNPVC
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
Bovine
Mouse
ELISA Kit for Human DHPDHase
ELISA Kit for Human DHPDHase
ELISA Kit for Human DHPDHase
ELISA Kit for Human DHPDHase
ELISA Kit for Human DHPDHase
CLIA Kit for Human DHPDHase
CLIA Kit for Human DHPDHase
CLIA Kit for Human DHPDHase
CLIA Kit for Human DHPDHase
CLIA Kit for Human DHPDHase
Polyclonal Antibody for Human DHPDHase
Polyclonal Antibody for Human DHPDHase
Polyclonal Antibody for Human DHPDHase
Polyclonal Antibody for Human DHPDHase
Polyclonal Antibody for Human DHPDHase
Monoclonal Antibody for Human DHPDHase
Monoclonal Antibody for Human DHPDHase
Monoclonal Antibody for Human DHPDHase
Monoclonal Antibody for Human DHPDHase
Monoclonal Antibody for Human DHPDHase
Protein for Human DHPDHase
Protein for Human DHPDHase
Protein for Human DHPDHase
Protein for Human DHPDHase
Protein for Human DHPDHase
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT DPYDD ARG-29
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Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS VAL-543 AND ILE-732
tissue :
Skin .
tissue :
Uterus .
9.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 581-635
tissue :
Liver .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 581-635
11.
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Cited for : CHARACTERIZATION;PARTIAL PROTEIN SEQUENCE
tissue :
Liver .
12.
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-384;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
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Cited for : VARIANTS DPYDD ARG-29; TRP-235 AND HIS-886
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS DPYDD ARG-29; TRP-235 AND HIS-886
16.
"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J.
,
Mardis E.R.
,
Ding L.
,
Fulton B.
,
McLellan M.D.
,
Chen K.
,
Dooling D.
,
Dunford-Shore B.H.
,
McGrath S.
,
Hickenbotham M.
,
Cook L.
,
Abbott R.
,
Larson D.E.
,
Koboldt D.C.
,
Pohl C.
,
Smith S.
,
Hawkins A.
,
Abbott S.
,
Locke D.
,
Hillier L.W.
,
Miner T.
,
Fulton L.
,
Magrini V.
,
Wylie T.
,
Glasscock J.
,
Conyers J.
,
Sander N.
,
Shi X.
,
Osborne J.R.
,
Minx P.
,
Gordon D.
,
Chinwalla A.
,
Zhao Y.
,
Ries R.E.
,
Payton J.E.
,
Westervelt P.
,
Tomasson M.H.
,
Watson M.
,
Baty J.
,
Ivanovich J.
,
Heath S.
,
Shannon W.D.
,
Nagarajan R.
,
Walter M.J.
,
Link D.C.
,
Graubert T.A.
,
DiPersio J.F.
,
Wilson R.K.
more...
Nature456:66-72(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] ARG-29