Gene name:
DPYSL2 (CRMP2;ULIP2) ;
Protein name:
Dihydropyrimidinase-related protein 2 (DRP-2) ;
Alternative:
N2A3 ;Collapsin response mediator protein 2 (CRMP-2) ;Unc-33-like phosphoprotein 2 (ULIP-2) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4.
Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSYQGKKNIP | RITSDRLLIK | GGKIVNDDQS | FYADIYMEDG | LIKQIGENLI |
100:
VPGGVKTIEA | HSRMVIPGGI | DVHTRFQMPD | QGMTSADDFF | QGTKAALAGG |
150:
TTMIIDHVVP | EPGTSLLAAF | DQWREWADSK | SCCDYSLHVD | ISEWHKGIQE |
200:
EMEALVKDHG | VNSFLVYMAF | KDRFQLTDCQ | IYEVLSVIRD | IGAIAQVHAE |
250:
NGDIIAEEQQ | RILDLGITGP | EGHVLSRPEE | VEAEAVNRAI | TIANQTNCPL |
300:
YITKVMSKSS | AEVIAQARKK | GTVVYGEPIT | ASLGTDGSHY | WSKNWAKAAA |
350:
FVTSPPLSPD | PTTPDFLNSL | LSCGDLQVTG | SAHCTFNTAQ | KAVGKDNFTL |
400:
IPEGTNGTEE | RMSVIWDKAV | VTGKMDENQF | VAVTSTNAAK | VFNLYPRKGR |
450:
IAVGSDADLV | IWDPDSVKTI | SAKTHNSSLE | YNIFEGMECR | GSPLVVISQG |
500:
KIVLEDGTLH | VTEGSGRYIP | RKPFPDFVYK | RIKARSRLAE | LRGVPRGLYD |
550:
GPVCEVSVTP | KTVTPASSAK | TSPAKQQAPP | VRNLHQSGFS | LSGAQIDDNI |
572:
PRRTTQRIVA | PPGGRANITS | LG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Human
Rat
Chicken
ELISA Kit for Human DRP-2
ELISA Kit for Human DRP-2
ELISA Kit for Human DRP-2
ELISA Kit for Human DRP-2
ELISA Kit for Human DRP-2
Polyclonal Antibody for Human DRP-2
Polyclonal Antibody for Human DRP-2
Polyclonal Antibody for Human DRP-2
Polyclonal Antibody for Human DRP-2
Polyclonal Antibody for Human DRP-2
Monoclonal Antibody for Human DRP-2
Monoclonal Antibody for Human DRP-2
Monoclonal Antibody for Human DRP-2
Monoclonal Antibody for Human DRP-2
Monoclonal Antibody for Human DRP-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Fetal liver .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Eye .
tissue :
Testis .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 44-56; 64-75; 147-157; 174-211; 239-254; 375-390; 401-418; 424-467; 497-511 AND 533-552;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Brain .
tissue :
Cajal-Retzius cell .
tissue :
Fetal brain cortex .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-518; SER-522 AND THR-509;MUTAGENESIS OF SER-507; THR-509; THR-512; THR-514; SER-517; SER-518; THR-521 AND SER-522
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT SER-522
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CYFIP1;MUTAGENESIS OF ASP-71
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PLEXNA1;SUBUNIT
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-509 AND SER-522;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-509;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-32 BY FYN
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CLN6
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN ENDOCYTOSIS;INTERACTION WITH MICALL1;SUBCELLULAR LOCATION
21.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
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Vermeulen M.
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Santamaria A.
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
22.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-509; THR-514; SER-517; SER-518 AND SER-522;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 12-490;SUBUNIT
25.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] CYS-481