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Index > Protein center > DSPP(Gene name) > Human
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  • DSPP (Gene name),
  • Dentin sialophosphoprotein (Protein name ),  DSPP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    DSPP;
    Protein name:
    Dentin sialophosphoprotein;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with FBLN7.
    Function:
    DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    1301
    Sequence:
    50:
    MKIITYFCIW | AVAWAIPVPQ | SKPLERHVEK | SMNLHLLARS | NVSVQDELNA | 
    100:
    SGTIKESGVL | VHEGDRGRQE | NTQDGHKGEG | NGSKWAEVGG | KSFSTYSTLA | 
    150:
    NEEGNIEGWN | GDTGKAETYG | HDGIHGKEEN | ITANGIQGQV | SIIDNAGATN | 
    200:
    RSNTNGNTDK | NTQNGDVGDA | GHNEDVAVVQ | EDGPQVAGSN | NSTDNEDEII | 
    250:
    ENSCRNEGNT | SEITPQINSK | RNGTKEAEVT | PGTGEDAGLD | NSDGSPSGNG | 
    300:
    ADEDEDEGSG | DDEDEEAGNG | KDSSNNSKGQ | EGQDHGKEDD | HDSSIGQNSD | 
    350:
    SKEYYDPEGK | EDPHNEVDGD | KTSKSEENSA | GIPEDNGSQR | IEDTQKLNHR | 
    400:
    ESKRVENRIT | KESETHAVGK | SQDKGIEIKG | PSSGNRNITK | EVGKGNEGKE | 
    450:
    DKGQHGMILG | KGNVKTQGEV | VNIEGPGQKS | EPGNKVGHSN | TGSDSNSDGY | 
    500:
    DSYDFDDKSM | QGDDPNSSDE | SNGNDDANSE | SDNNSSSRGD | ASYNSDESKD | 
    550:
    NGNGSDSKGA | EDDDSDSTSD | TNNSDSNGNG | NNGNDDNDKS | DSGKGKSDSS | 
    600:
    DSDSSDSSNS | SDSSDSSDSD | SSDSNSSSDS | DSSDSDSSDS | SDSDSSDSSN | 
    650:
    SSDSSDSSDS | SDSSDSSDSS | DSKSDSSKSE | SDSSDSDSKS | DSSDSNSSDS | 
    700:
    SDNSDSSDSS | NSSNSSDSSD | SSDSSDSSSS | SDSSNSSDSS | DSSDSSNSSE | 
    750:
    SSDSSDSSDS | DSSDSSDSSN | SNSSDSDSSN | SSDSSDSSNS | SDSSDSSDSS | 
    800:
    NSSDSSDSSD | SSNSSDSSDS | SDSSDSSDSS | NSSDSNDSSN | SSDSSDSSNS | 
    850:
    SDSSNSSDSS | DSSDSSDSDS | SNSSDSSNSS | DSSDSSNSSD | SSDSSDSSDG | 
    900:
    SDSDSSNRSD | SSNSSDSSDS | SDSSNSSDSS | DSSDSNESSN | SSDSSDSSNS | 
    950:
    SDSDSSDSSN | SSDSSDSSNS | SDSSESSNSS | DNSNSSDSSN | SSDSSDSSDS | 
    1000:
    SNSSDSSNSS | DSSNSSDSSD | SNSSDSSDSS | NSSDSSDSSD | SSDSSDSSDS | 
    1050:
    SNSSDSSDSS | DSSDSSNSSD | SSNSSDSSNS | SDSSDSSDSS | DSSDSSDSSD | 
    1100:
    SSDSSNSSDS | SDSSDSSDSS | DSSDSSDSSD | SSESSDSSDS | SNSSDSSDSS | 
    1150:
    DSSDSSDSSD | SSDSSDSSDS | SNSSDSSDSS | DSSDSSDSSN | SSDSSDSSES | 
    1200:
    SDSSDSSDSS | DSSDSSDSSD | SSDSSDSSNS | SDSSDSSDSS | DSSDSSDSSD | 
    1250:
    SSDSSDSSDS | SDSSDSSDSS | DSSDSSDSSD | SNESSDSSDS | SDSSDSSNSS | 
    1300:
    DSSDSSDSSD | STSDSNDESD | SQSKSGNGNN | NGSDSDSDSE | GSDSNHSTSD | 
    1301:
    D
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Dentin sialophosphoprotein
    Cat.:
    E2162h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Dentin sialophosphoprotein
    Cat.:
    E2162m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Dentin sialophosphoprotein
    Cat.:
    E2162r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dentin sialophosphoprotein
    Cat.:
    U2162r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dentin sialophosphoprotein
    Cat.:
    U2162m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dentin sialophosphoprotein
    Cat.:
    U2162h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Dentin sialophosphoprotein
    Cat.:
    P2162Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dentin sialophosphoprotein
    Cat.:
    P2162Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dentin sialophosphoprotein
    Cat.:
    P2162Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Dentin sialophosphoprotein
    Monoclonal Antibody for Human Dentin sialophosphoprotein
    Monoclonal Antibody for Human Dentin sialophosphoprotein
    Protein for Human Dentin sialophosphoprotein
    Protein for Human Dentin sialophosphoprotein
    Protein for Human Dentin sialophosphoprotein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of a human dentin sialophosphoprotein gene."
      Gu K. , Chang S.R. , Ritchie H.H. , Clarkson B.H. , Rutherford R.B.
      Eur. J. Oral Sci.108:35-42(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "Human dentin phosphophoryn nucleotide and amino acid sequence."
      Gu K. , Chang S.R. , Slaven M.S. , Clarkson B.H. , Rutherford R.B. , Ritchie H.H.
      Eur. J. Oral Sci.106:1043-1047(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 463-1301
      tissue: Tooth.
    4. 4.
      "DSPP mutation in dentinogenesis imperfecta Shields type II."
      Zhang X. , Zhao J. , Li C. , Gao S. , Qiu C. , Liu P. , Wu G. , Qiang B. , Lo W.H.Y. , Shen Y.
      Nat. Genet.27:151-152(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DGI2
    5. 5.
      "A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene."
      McKnight D.A. , Suzanne Hart P. , Hart T.C. , Hartsfield J.K. , Wilson A. , Wright J.T. , Fisher L.W.
      Hum. Mutat.29:1392-1404(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DGI2; DGI3 AND DTDP2;VARIANT DGI3 SER-17
    6. 6.
      "Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP."
      Xiao S. , Yu C. , Chou X. , Yuan W. , Wang Y. , Bu L. , Fu G. , Qian M. , Yang J. , Shi Y. , Hu L. , Han B. , Wang Z. , Huang W. , Liu J. , Chen Z. , Zhao G. , Kong X.
      Nat. Genet.27:201-204(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DFNA39/DGI1 THR-17 AND PHE-18
    7. 7.
      "Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization."
      Rajpar M.H. , Koch M.J. , Davies R.M. , Mellody K.T. , Kielty C.M. , Dixon M.J.
      Hum. Mol. Genet.11:2559-2565(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DTDP2 ASP-6;CHARACTERIZATION OF VARIANT DTDP2 ASP-6
    8. 8.
      "Clinical, histopathologic, and genetic investigation in two large families with dentinogenesis imperfecta type II."
      Malmgren B. , Lindskog S. , Elgadi A. , Norgren S.
      Hum. Genet.114:491-498(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DGI2 VAL-15 AND TRP-68
    9. 9.
      "Mutational hot spot in the DSPP gene causing dentinogenesis imperfecta type II."
      Kim J.-W. , Hu J.C.-C. , Lee J.-I. , Moon S.-K. , Kim Y.-J. , Jang K.-T. , Lee S.-H. , Kim C.-C. , Hahn S.-H. , Simmer J.P.
      Hum. Genet.116:186-191(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DGI3 PHE-18
    10. 10.
      "DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis."
      Lorenz-Depiereux B. , Bastepe M. , Benet-Pages A. , Amyere M. , Wagenstaller J. , Mueller-Barth U. , Badenhoop K. , Kaiser S.M. , Rittmaster R.S. , Shlossberg A.H. , Olivares J.L. , Loris C. , Ramos F.J. , Glorieux F. , Vikkula M. , Jueppner H. , Strom T.M.
      Nat. Genet.38:1248-1250(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-68
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DGI2 SER-17
    12. 12.
      "Identification of the DSPP mutation in a new kindred and phenotype-genotype correlation."
      Lee S.K. , Lee K.E. , Hwang Y.H. , Kida M. , Tsutsumi T. , Ariga T. , Park J.C. , Kim J.W.
      Oral Dis.17:314-319(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DGI2 ASP-18
    13. 13.
      "Rough endoplasmic reticulum trafficking errors by different classes of mutant dentin sialophosphoprotein (DSPP) cause dominant negative effects in both dentinogenesis imperfecta and dentin dysplasia by entrapping normal DSPP."
      von Marschall Z. , Mok S. , Phillips M.D. , McKnight D.A. , Fisher L.W.
      J. Bone Miner. Res.27:1309-1321(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT DFNA39/DGI1 THR-17;CHARACTERIZATION OF VARIANTS DGI2 VAL-15; SER-17 AND ASP-18
    14. 14.
      "A DSPP mutation causing dentinogenesis imperfecta and characterization of the mutational effect."
      Lee S.K. , Lee K.E. , Song S.J. , Hyun H.K. , Lee S.H. , Kim J.W.
      Biomed. Res. Int.2013:948181-948181(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DGI3 LEU-17;CHARACTERIZATION OF VARIANT DGI3 LEU-17
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