DTNBP1 ELISA Kit for Human(Homo sapiens) | EIAab.comDTNBP1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > DTNBP1(Gene name) > Human

DTNBP1 (Gene name),

Dysbindin (Protein name ), DTBP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

DTNBP1(My031;My031;BLOC1S8);

Protein name:

Dysbindin;

Alternative:

Dystrobrevin-binding protein 1;Dysbindin-1(BLOC-1 subunit 8);Hermansky-Pudlak syndrome 7 protein(HPS7 protein);Hermansky-Pudlak syndrome 7 protein(HPS7 protein);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. Binds to DTNA and DTNB but may not be a physiological binding partner (PubMed:16980328). Interacts with RNF151 and CMYA5 (By similarity). Identified in a complex with the adapter-related protein complex 3 (AP-3). Interacts with TRIM32, AP3M1 and AP3B2. Identified in a complex with the biogenesis of lysosome-related organelles complex 2 (BLOC-2). Interacts with the DNA-dependent protein kinase complex DNA-PK.

Function:

The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation.

Subcellular Location:

Cytoplasm Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane Peripheral membrane protein Cytoplasmic side Endosome membrane Peripheral membrane protein Cytoplasmic side Melanosome membrane Peripheral membrane protein Cytoplasmic side Nucleus Cell junction synapse postsynaptic cell membrane postsynaptic density Endoplasmic reticulum Detected in neuron cell bodies, axons and dendrites. Detected at synapses, at post-synaptic density, at pre-synaptic vesicle membranes and microtubules. Detected at tubulovesicular elements in the vicinity of the Golgi apparatus and of melanosomes. Occasionally detected at the membrane of pigmented melanosomes in cultured melanoma cells.

Protein Attributes:

Sequence length:

351

Sequence:

50:

100:

150:

200:

250:

300:

350:

351:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

607145

KEGG:

hsa:84062

UniGene:

Hs.571148

String:

Q96EV8

STRING:

9606.ENSP00000341680

Pfam:

PF04440

Uniprot:

Q96EV8

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ELISA Kit for Human Dysbindin

Cat.:

E14962h

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Packing:

96T

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ELISA Kit for Human Dysbindin

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ELISA Kit for Human Dysbindin

MSDS:

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ELISA Kit for Human Dysbindin

MSDS:

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ELISA Kit for Human Dysbindin

Cat.:

E14962m

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Packing:

96T

CLIA Kit for Human Dysbindin

Cat.:

U14962h

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Packing:

96T

CLIA Kit for Human Dysbindin

MSDS:

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CLIA Kit for Human Dysbindin

MSDS:

Please sign in first.

CLIA Kit for Human Dysbindin

MSDS:

Please sign in first.

CLIA Kit for Human Dysbindin

Cat.:

U14962m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Dysbindin

Monoclonal Antibody for Human Dysbindin

Protein for Human Dysbindin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)."
Li W. , Zhang Q. , Oiso N. , Novak E.K. , Gautam R. , O'Brien E.P. , Tinsley C.L. , Blake D.J. , Spritz R.A. , Copeland N.G. , Jenkins N.A. , Amato D. , Roe B.A. , Starcevic M. , Dell'Angelica E.C. , Elliott R.W. , Mishra V. , Kingsmore S.F. , more...
Nat. Genet.35:84-89(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INVOLVEMENT IN HPS7
tissue: Placenta.
2.

"Localization and identification of a human DTNBP1 gene from a putative schizophrenia susceptibility locus on 6p22.3 by in silico cloning."
Jiang Y. , Straub R.E. , Sullivan P.F. , Chen X. , O'Neill F.A. , Walsh D. , Kendler K.S. , Riley B.P.
Submitted (2001-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
3.

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S. , Weil B. , Wellenreuther R. , Gassenhuber J. , Glassl S. , Ansorge W. , Boecher M. , Bloecker H. , Bauersachs S. , Blum H. , Lauber J. , Duesterhoeft A. , Beyer A. , Koehrer K. , Strack N. , Mewes H.-W. , Ottenwaelder B. , Obermaier B. , more...
Genome Res.11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Lung.
tissue: Neuroblastoma.
5.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Muscle.
7.

Mao Y.M. , Xie Y. , Ying K.
Submitted (1998-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-351 (ISOFORM 1)
tissue: Fetal brain.
8.

"Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia."
Numakawa T. , Yagasaki Y. , Ishimoto T. , Okada T. , Suzuki T. , Iwata N. , Ozaki N. , Taguchi T. , Tatsumi M. , Kamijima K. , Straub R.E. , Weinberger D.R. , Kunugi H. , Hashimoto R.
Hum. Mol. Genet.13:2699-2708(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH SCHIZOPHRENIA;FUNCTION
9.

"Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia."
Talbot K. , Eidem W.L. , Tinsley C.L. , Benson M.A. , Thompson E.W. , Smith R.J. , Hahn C.G. , Siegel S.J. , Trojanowski J.Q. , Gur R.E. , Blake D.J. , Arnold S.E.
J. Clin. Invest.113:1353-1363(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH SCHIZOPHRENIA;TISSUE SPECIFICITY (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION
10.

"Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin."
Talbot K. , Cho D.S. , Ong W.Y. , Benson M.A. , Han L.Y. , Kazi H.A. , Kamins J. , Hahn C.G. , Blake D.J. , Arnold S.E.
Hum. Mol. Genet.15:3041-3054(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
11.

"BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes."
Di Pietro S.M. , Falcon-Perez J.M. , Tenza D. , Setty S.R. , Marks M.S. , Raposo G. , Dell'Angelica E.C.
Mol. Biol. Cell17:4027-4038(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION
12.

"BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."
Setty S.R. , Tenza D. , Truschel S.T. , Chou E. , Sviderskaya E.V. , Theos A.C. , Lamoreux M.L. , Di Pietro S.M. , Starcevic M. , Bennett D.C. , Dell'Angelica E.C. , Raposo G. , Marks M.S.
Mol. Biol. Cell18:768-780(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BLOC-1 COMPLEX;FUNCTION
13.

"Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization."
Iizuka Y. , Sei Y. , Weinberger D.R. , Straub R.E.
J. Neurosci.27:12390-12395(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression."
Tang J. , LeGros R.P. , Louneva N. , Yeh L. , Cohen J.W. , Hahn C.G. , Blake D.J. , Arnold S.E. , Talbot K.
Hum. Mol. Genet.18:3851-3863(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH SCHIZOPHRENIA
16.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
17.

"Dysbindin-1 and its protein family with special attention to the potential role of dysbindin-1 in neuronal functions and the pathophysiology of schizophrenia."
Talbot K. , Ong W.-Y. , Blake D.J. , Tang J. , Louneva N. , Carlson G.C. , Arnold S.E.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
18.

"Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization."
Kubota K. , Kumamoto N. , Matsuzaki S. , Hashimoto R. , Hattori T. , Okuda H. , Takamura H. , Takeda M. , Katayama T. , Tohyama M.
Biochem. Biophys. Res. Commun.379:191-195(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"TRIM32 is an E3 ubiquitin ligase for dysbindin."
Locke M. , Tinsley C.L. , Benson M.A. , Blake D.J.
Hum. Mol. Genet.18:2344-2358(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM32;SUBCELLULAR LOCATION;UBIQUITINATION
20.

"Direct interaction of dysbindin with the AP-3 complex via its mu subunit."
Taneichi-Kuroda S. , Taya S. , Hikita T. , Fujino Y. , Kaibuchi K.
Neurochem. Int.54:431-438(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP3M1;MUTAGENESIS OF TYR-215
21.

"Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner."
Oyama S. , Yamakawa H. , Sasagawa N. , Hosoi Y. , Futai E. , Ishiura S.
PLoS ONE4:E4199-E4199(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3);INTERACTION WITH AP3B2; XRCC5 AND XRCC6 IN THE DNA-DEPENDENT PROTEIN KINASE COMPLEX DNA-PK;PHOSPHORYLATION
22.

"DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophrenias."
Fallgatter A.J. , Ehlis A.C. , Herrmann M.J. , Hohoff C. , Reif A. , Freitag C.M. , Deckert J.
Genes Brain Behav.9:489-497(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH SCHIZOPHRENIA;FUNCTION
23.

"Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression."
Fei E. , Ma X. , Zhu C. , Xue T. , Yan J. , Xu Y. , Zhou J. , Wang G.
J. Biol. Chem.285:38630-38640(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION;INTERACTION WITH XPO1;MUTAGENESIS OF 243-LEU--LEU-256
24.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location."
Talbot K. , Louneva N. , Cohen J.W. , Kazi H. , Blake D.J. , Arnold S.E.
PLoS ONE6:E16886-E16886(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH SCHIZOPHRENIA;TISSUE SPECIFICITY (ISOFORMS 1; 2 AND 3);SUBCELLULAR LOCATION (ISOFORMS 1; 2 AND 3)
26.

"Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."
Lee H.H. , Nemecek D. , Schindler C. , Smith W.J. , Ghirlando R. , Steven A.C. , Bonifacino J.S. , Hurley J.H.
J. Biol. Chem.287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BLOC-1 COMPLEX;COMPOSITION OF THE BLOC-1 COMPLEX

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