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Index > Protein center > DUOX2(Gene name) > Human
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  • DUOX2 (Gene name),
  • Dual oxidase 2 (Protein name ),  DUOX2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DUOX2(LNOX2;THOX2);
    Protein name:
    Dual oxidase 2;
    Alternative:
    Long NOX 2;Large NOX 2;NADPH oxidase/peroxidase DUOX2;NADH/NADPH thyroid oxidase p138-tox;Thyroid oxidase 2;NADPH thyroid oxidase 2;p138 thyroid oxidase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TXNDC11, TPO and CYBA.
    Function:
    Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
    Subcellular Location:
    Apical cell membrane Multi-pass membrane protein Localizes to the apical membrane of epithelial cells.
    Protein Attributes:
    Sequence length:
    1548
    Sequence:
    50:
    MLRARPEALM | LLGALLTGSL | GPSGNQDALS | LPWEVQRYDG | WFNNLRHHER | 
    100:
    GAVGCRLQRR | VPANYADGVY | QALEEPQLPN | PRRLSNAATR | GIAGLPSLHN | 
    150:
    RTVLGVFFGY | HVLSDVVSVE | TPGCPAEFLN | IRIPPGDPVF | DPDQRGDVVL | 
    200:
    PFQRSRWDPE | TGRSPSNPRD | LANQVTGWLD | GSAIYGSSHS | WSDALRSFSG | 
    250:
    GQLASGPDPA | FPRDSQNPLL | MWAAPDPATG | QNGPRGLYAF | GAERGNREPF | 
    300:
    LQALGLLWFR | YHNLWAQRLA | RQHPDWEDEE | LFQHARKRVI | ATYQNIAVYE | 
    350:
    WLPSFLQKTL | PEYTGYRPFL | DPSISPEFVV | ASEQFFSTMV | PPGVYMRNAS | 
    400:
    CHFRKVLNKG | FQSSQALRVC | NNYWIRENPN | LNSTQEVNEL | LLGMASQISE | 
    450:
    LEDNIVVEDL | RDYWPGPGKF | SRTDYVASSI | QRGRDMGLPS | YSQALLAFGL | 
    500:
    DIPRNWSDLN | PNVDPQVLEA | TAALYNQDLS | QLELLLGGLL | ESHGDPGPLF | 
    550:
    SAIVLDQFVR | LRDGDRYWFE | NTRNGLFSKK | EIEDIRNTTL | RDVLVAVINI | 
    600:
    DPSALQPNVF | VWHKGAPCPQ | PKQLTTDGLP | QCAPLTVLDF | FEGSSPGFAI | 
    650:
    TIIALCCLPL | VSLLLSGVVA | YFRGREHKKL | QKKLKESVKK | EAAKDGVPAM | 
    700:
    EWPGPKERSS | PIIIQLLSDR | CLQVLNRHLT | VLRVVQLQPL | QQVNLILSNN | 
    750:
    RGCRTLLLKI | PKEYDLVLLF | SSEEERGAFV | QQLWDFCVRW | ALGLHVAEMS | 
    800:
    EKELFRKAVT | KQQRERILEI | FFRHLFAQVL | DINQADAGTL | PLDSSQKVRE | 
    850:
    ALTCELSRAE | FAESLGLKPQ | DMFVESMFSL | ADKDGNGYLS | FREFLDILVV | 
    900:
    FMKGSPEDKS | RLMFTMYDLD | ENGFLSKDEF | FTMMRSFIEI | SNNCLSKAQL | 
    950:
    AEVVESMFRE | SGFQDKEELT | WEDFHFMLRD | HDSELRFTQL | CVKGGGGGGN | 
    1000:
    GIRDIFKQNI | SCRVSFITRT | PGERSHPQGL | GPPAPEAPEL | GGPGLKKRFG | 
    1050:
    KKAAVPTPRL | YTEALQEKMQ | RGFLAQKLQQ | YKRFVENYRR | HIVCVAIFSA | 
    1100:
    ICVGVFADRA | YYYGFASPPS | DIAQTTLVGI | ILSRGTAASV | SFMFSYILLT | 
    1150:
    MCRNLITFLR | ETFLNRYVPF | DAAVDFHRWI | AMAAVVLAIL | HSAGHAVNVY | 
    1200:
    IFSVSPLSLL | ACIFPNVFVN | DGSKLPQKFY | WWFFQTVPGM | TGVLLLLVLA | 
    1250:
    IMYVFASHHF | RRRSFRGFWL | THHLYILLYA | LLIIHGSYAL | IQLPTFHIYF | 
    1300:
    LVPAIIYGGD | KLVSLSRKKV | EISVVKAELL | PSGVTYLQFQ | RPQGFEYKSG | 
    1350:
    QWVRIACLAL | GTTEYHPFTL | TSAPHEDTLS | LHIRAVGPWT | TRLREIYSSP | 
    1400:
    KGNGCAGYPK | LYLDGPFGEG | HQEWHKFEVS | VLVGGGIGVT | PFASILKDLV | 
    1450:
    FKSSLGSQML | CKKIYFIWVT | RTQRQFEWLA | DIIQEVEEND | HQDLVSVHIY | 
    1500:
    VTQLAEKFDL | RTTMLYICER | HFQKVLNRSL | FTGLRSITHF | GRPPFEPFFN | 
    1548:
    SLQEVHPQVR | KIGVFSCGPP | GMTKNVEKAC | QLVNRQDRAH | FMHHYENF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    MIM:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Dual oxidase 2
    Cat.:
    E9487h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Dual oxidase 2
    Cat.:
    E9487r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Dual oxidase 2
    Cat.:
    E9487p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dual oxidase 2
    Cat.:
    U9487r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dual oxidase 2
    Cat.:
    U9487h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Dual oxidase 2
    Cat.:
    U9487p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Dual oxidase 2
    Cat.:
    P9487Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dual oxidase 2
    Polyclonal Antibody for Human Dual oxidase 2
    Monoclonal Antibody for Human Dual oxidase 2
    Monoclonal Antibody for Human Dual oxidase 2
    Monoclonal Antibody for Human Dual oxidase 2
    Protein for Human Dual oxidase 2
    Protein for Human Dual oxidase 2
    Protein for Human Dual oxidase 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family."
      De Deken X. , Wang D. , Many M.-C. , Costagliola S. , Libert F. , Vassart G. , Dumont J.E. , Miot F.
      J. Biol. Chem.275:23227-23233(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION;TISSUE SPECIFICITY;VARIANT LEU-1067
      tissue: Thyroid.
    2. 2.
      "Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox."
      Edens W.A. , Sharling L. , Cheng G. , Shapira R. , Kinkade J.M. , Lee T. , Edens H.A. , Tang X. , Sullards C. , Flaherty D.B. , Benian G.M. , Lambeth J.D.
      J. Cell Biol.154:879-891(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS LEU-138 AND LEU-1067;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
      tissue: Pancreas.
      tissue: Thyroid.
    3. 4.
      "Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs."
      Dupuy C. , Ohayon R. , Valent A. , Noel-Hudson M.-S. , Deme D. , Virion A.
      J. Biol. Chem.274:37265-37269(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 339-1548;VARIANT LEU-1067
      tissue: Thyroid.
    4. 5.
      "Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital hypothyroidism."
      Hoste C. , Rigutto S. , Van Vliet G. , Miot F. , De Deken X.
      Hum. Mutat.31:E1304-E1319(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1509-1548;VARIANT TDH6 SER-1518;CHARACTERIZATION OF VARIANT TDH6 SER-1518
    5. 6.
      "Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system."
      De Deken X. , Wang D. , Dumont J.E. , Miot F.
      Exp. Cell Res.273:187-196(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
    6. 7.
      "Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism."
      Moreno J.C. , Bikker H. , Kempers M.J.E. , van Trotsenburg A.S. , Baas F. , de Vijlder J.J.M. , Vulsma T. , Ris-Stalpers C.
      N. Engl. J. Med.347:95-102(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN TDH6
    7. 8.
      "Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense."
      Geiszt M. , Witta J. , Baffi J. , Lekstrom K. , Leto T.L.
      FASEB J.17:1502-1504(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    8. 9.
      "NADPH oxidase-dependent acid production in airway epithelial cells."
      Schwarzer C. , Machen T.E. , Illek B. , Fischer H.
      J. Biol. Chem.279:36454-36461(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    10. 11.
      "Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."
      Wang D. , De Deken X. , Milenkovic M. , Song Y. , Pirson I. , Dumont J.E. , Miot F.
      J. Biol. Chem.280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TXNDC11; TPO AND CYBA
    11. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;ENZYME REGULATION
    12. 13.
      "Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings."
      Vigone M.C. , Fugazzola L. , Zamproni I. , Passoni A. , Di Candia S. , Chiumello G. , Persani L. , Weber G.
      Hum. Mutat.26:395-395(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH6 TRP-376
    13. 14.
      "Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A-->C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect."
      Varela V. , Rivolta C.M. , Esperante S.A. , Gruneiro-Papendieck L. , Chiesa A. , Targovnik H.M.
      Clin. Chem.52:182-191(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH6 HIS-36
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