DUOX2 ELISA Kit for Human(Homo sapiens) | EIAab.comDUOX2 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > DUOX2(Gene name) > Human

DUOX2 (Gene name),

Dual oxidase 2 (Protein name ), DUOX2_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

DUOX2(LNOX2;THOX2);

Protein name:

Dual oxidase 2;

Alternative:

Long NOX 2;Large NOX 2;NADPH oxidase/peroxidase DUOX2;NADH/NADPH thyroid oxidase p138-tox;Thyroid oxidase 2;NADPH thyroid oxidase 2;p138 thyroid oxidase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with TXNDC11, TPO and CYBA.

Function:

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

Subcellular Location:

Apical cell membrane Multi-pass membrane protein Localizes to the apical membrane of epithelial cells.

Protein Attributes:

Sequence length:

1548

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1400:

1450:

1500:

1548:

SLQEVHPQVR | KIGVFSCGPP | GMTKNVEKAC | QLVNRQDRAH | FMHHYENF

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Hs.71377

KEGG:

hsa:50506

MIM:

606759

SMR:

Q9NRD8

STRING:

9606.ENSP00000267837

String:

Q9NRD8

Pfam:

PF03098

Uniprot:

Q9NRD8

FOR

ELISA Kit for Human Dual oxidase 2

Cat.:

E9487h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Dual oxidase 2

Cat.:

E9487r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Dual oxidase 2

Cat.:

E9487p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Dual oxidase 2

Cat.:

U9487r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Dual oxidase 2

Cat.:

U9487h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Dual oxidase 2

Cat.:

U9487p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Dual oxidase 2

Cat.:

P9487Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Dual oxidase 2

Monoclonal Antibody for Human Dual oxidase 2

Protein for Human Dual oxidase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family."
De Deken X. , Wang D. , Many M.-C. , Costagliola S. , Libert F. , Vassart G. , Dumont J.E. , Miot F.
J. Biol. Chem.275:23227-23233(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION;TISSUE SPECIFICITY;VARIANT LEU-1067
tissue: Thyroid.
2.

"Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox."
Edens W.A. , Sharling L. , Cheng G. , Shapira R. , Kinkade J.M. , Lee T. , Edens H.A. , Tang X. , Sullards C. , Flaherty D.B. , Benian G.M. , Lambeth J.D.
J. Cell Biol.154:879-891(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS LEU-138 AND LEU-1067;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
tissue: Pancreas.
tissue: Thyroid.
3.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs."
Dupuy C. , Ohayon R. , Valent A. , Noel-Hudson M.-S. , Deme D. , Virion A.
J. Biol. Chem.274:37265-37269(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 339-1548;VARIANT LEU-1067
tissue: Thyroid.
5.

"Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital hypothyroidism."
Hoste C. , Rigutto S. , Van Vliet G. , Miot F. , De Deken X.
Hum. Mutat.31:E1304-E1319(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1509-1548;VARIANT TDH6 SER-1518;CHARACTERIZATION OF VARIANT TDH6 SER-1518
6.

"Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system."
De Deken X. , Wang D. , Dumont J.E. , Miot F.
Exp. Cell Res.273:187-196(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
7.

"Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism."
Moreno J.C. , Bikker H. , Kempers M.J.E. , van Trotsenburg A.S. , Baas F. , de Vijlder J.J.M. , Vulsma T. , Ris-Stalpers C.
N. Engl. J. Med.347:95-102(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN TDH6
8.

"Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense."
Geiszt M. , Witta J. , Baffi J. , Lekstrom K. , Leto T.L.
FASEB J.17:1502-1504(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
9.

"NADPH oxidase-dependent acid production in airway epithelial cells."
Schwarzer C. , Machen T.E. , Illek B. , Fischer H.
J. Biol. Chem.279:36454-36461(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
10.

"Dual oxidase2 is expressed all along the digestive tract."
Ameziane-El-Hassani R. , Benfares N. , Caillou B. , Talbot M. , Sabourin J.-C. , Belotte V. , Morand S. , Gnidehou S. , Agnandji D. , Ohayon R. , Kaniewski J. , Noel-Hudson M.-S. , Bidart J.-M. , Schlumberger M. , Virion A. , Dupuy C.
Am. J. Physiol.288:G933-G942(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
11.

"Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."
Wang D. , De Deken X. , Milenkovic M. , Song Y. , Pirson I. , Dumont J.E. , Miot F.
J. Biol. Chem.280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TXNDC11; TPO AND CYBA
12.

"Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity."
Ameziane-El-Hassani R. , Morand S. , Boucher J.L. , Frapart Y.-M. , Apostolou D. , Agnandji D. , Gnidehou S. , Ohayon R. , Noel-Hudson M.-S. , Francon J. , Lalaoui K. , Virion A. , Dupuy C.
J. Biol. Chem.280:30046-30054(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;ENZYME REGULATION
13.

"Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings."
Vigone M.C. , Fugazzola L. , Zamproni I. , Passoni A. , Di Candia S. , Chiumello G. , Persani L. , Weber G.
Hum. Mutat.26:395-395(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH6 TRP-376
14.

"Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A-->C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect."
Varela V. , Rivolta C.M. , Esperante S.A. , Gruneiro-Papendieck L. , Chiesa A. , Targovnik H.M.
Clin. Chem.52:182-191(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH6 HIS-36

Product Feedback Wall

* Email:
*Comments: