DUT ELISA Kit for Human(Homo sapiens) | EIAab.comDUT ELISA Kit for Human(Homo sapiens)

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Index > Protein center > DUT(Gene name) > Human

DUT (Gene name),

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (Protein name ), DUT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

DUT;

Protein name:

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(dUTPase);

Alternative:

dUTP pyrophosphatase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer.

Function:

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Subcellular Location:

Isoform 3 Mitochondrion

Protein Attributes:

Sequence length:

252

Sequence:

50:

100:

150:

200:

250:

252:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1854

UniGene:

Hs.527980

String:

P33316

Pfam:

PF00692

SMR:

P33316

MIM:

601266

Uniprot:

P33316

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ELISA Kit for Human dUTPase

Cat.:

E1549h

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Manual:

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Packing:

96T

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ELISA Kit for Human dUTPase

Cat.:

E1549r

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Packing:

96T

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CLIA Kit for Human dUTPase

Cat.:

U1549h

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Packing:

96T

CLIA Kit for Human dUTPase

Cat.:

U1549r

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96T

Polyclonal Antibody for Human dUTPase

Cat.:

P1549Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human dUTPase

Cat.:

P1549Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human dUTPase

Protein for Human dUTPase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase."
Ladner R.D. , McNulty D.E. , Carr S.A. , Roberts G.D. , Caradonna S.J.
J. Biol. Chem.271:7745-7751(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF 70-93 (ISOFORM 3);PROTEIN SEQUENCE OF N-TERMINUS;PROTEIN SEQUENCE OF 94-115; 119-128; 133-151; 156-169; 180-206 AND 217-241 (ISOFORMS 2/3);CLEAVAGE OF INITIATOR METHIONINE (ISOFORM 2);SUBCELLULAR LOCATION;BIOPHYSICOCHEMICAL PROPERTIES;IDENTIFICATION BY MASS SPECTROMETRY
tissue: T-cell.
2.

"Assignment of the human dUTPase gene (DUT) to chromosome 15q15-q21. 1 by fluorescence in situ hybridization."
Cohen D. , Heng H.H.Q. , Shi X.-M. , McIntosh E.M. , Tsui L.-C. , Pearlman R.E.
Genomics40:213-215(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.

"Human genomic nuclear and mitochondria dUTPase gene."
Pearlman R.E.
Submitted (1997-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 3)
4.

"The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species."
Ladner R.D. , Caradonna S.J.
J. Biol. Chem.272:19072-19080(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-139 (ISOFORMS 2 AND 3);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Lung fibroblast.
5.

"Unknown transcriptional variant of nuclear dUTPase in human osteosarcoma."
Chano T. , Okabe H. , Baldini N. , Lapucci C. , Scotlandi K. , Serra M. , Saeki Y.
Submitted (2000-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
7.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
8.

NIEHS SNPs program
Submitted (2005-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-100
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue: Brain.
tissue: Eye.
tissue: Urinary bladder.
11.

"Human dUTP pyrophosphatase: cDNA sequence and potential biological importance of the enzyme."
McIntosh E.M. , Ager D.D. , Gadsden M.H. , Haynes R.H.
Proc. Natl. Acad. Sci. U.S.A.89:8020-8024(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 112-252
12.

McIntosh E.M. , Ager D.D. , Gadsden M.H. , Haynes R.H.
Proc. Natl. Acad. Sci. U.S.A.90:4328-4328(1993)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
13.

"Maturation stage and proliferation-dependent expression of dUTPase in human T cells."
Strahler J.R. , Zhu X.-X. , Wang Y.K. , Hora N. , Andrews P.C. , Roseman N.A. , Neel J.V. , Turka L. , Hanash S.M.
Proc. Natl. Acad. Sci. U.S.A.90:4991-4995(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 112-252;PARTIAL PROTEIN SEQUENCE;PHOSPHORYLATION
tissue: Lymphocyte.
14.

"Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase."
Ladner R.D. , Carr S.A. , Huddleston M.J. , McNulty D.E. , Caradonna S.J.
J. Biol. Chem.271:7752-7757(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;PHOSPHORYLATION AT SER-11 (ISOFORM 2);MUTAGENESIS OF SER-99;IDENTIFICATION BY MASS SPECTROMETRY
15.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits."
Mol C.D. , Harris J.M. , McIntosh E.M. , Tainer J.A.
Structure4:1077-1092(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 112-252 IN COMPLEX WITH SUBSTRATE AND MAGNESIUM IONS;COFACTOR;FUNCTION;CATALYTIC ACTIVITY;SUBUNIT
22.

"Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase."
Varga B. , Barabas O. , Kovari J. , Toth J. , Hunyadi-Gulyas E. , Klement E. , Medzihradszky K.F. , Toelgyesi F. , Fidy J. , Vertessy B.G.
FEBS Lett.581:4783-4788(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 89-252 (ISOFORM 2) IN COMPLEX WITH SUBSTRATE ANALOG AND MAGNESIUM IONS;IDENTIFICATION BY MASS SPECTROMETRY;SUBUNIT

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