Protein name:
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) ;
Alternative:
DSH homolog 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD (By similarity). Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site.
Function:
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasm
cytosol
Cytoplasmic vesicle
Localizes at the cell membrane upon interaction with frizzled family members.
Protein Attributes:
50:
MAETKIIYHM | DEEETPYLVK | LPVAPERVTL | ADFKNVLSNR | PVHAYKFFFK |
100:
SMDQDFGVVK | EEIFDDNAKL | PCFNGRVVSW | LVLAEGAHSD | AGSQGTDSHT |
150:
DLPPPLERTG | GIGDSRPPSF | HPNVASSRDG | MDNETGTESM | VSHRRERARR |
200:
RNREEAARTN | GHPRGDRRRD | VGLPPDSAST | ALSSELESSS | FVDSDEDGST |
250:
SRLSSSTEQS | TSSRLIRKHK | RRRRKQRLRQ | ADRASSFSSI | TDSTMSLNIV |
300:
TVTLNMERHH | FLGISIVGQS | NDRGDGGIYI | GSIMKGGAVA | ADGRIEPGDM |
350:
LLQVNDVNFE | NMSNDDAVRV | LREIVSQTGP | ISLTVAKCWD | PTPRSYFTVP |
400:
RADPVRPIDP | AAWLSHTAAL | TGALPRYGTS | PCSSAVTRTS | SSSLTSSVPG |
450:
APQLEEAPLT | VKSDMSAVVR | VMQLPDSGLE | IRDRMWLKIT | IANAVIGADV |
500:
VDWLYTHVEG | FKERREARKY | ASSLLKHGFL | RHTVNKITFS | EQCYYVFGDL |
550:
CSNLATLNLN | SGSSGTSDQD | TLAPLPHPAA | PWPLGQGYPY | QYPGPPPCFP |
600:
PAYQDPGFSY | GSGSTGSQQS | EGSKSSGSTR | SSRRAPGREK | ERRAAGAGGS |
650:
GSESDHTAPS | GVGSSWRERP | AGQLSRGSSP | RSQASATAPG | LPPPHPTTKA |
695:
YTVVGGPPGG | PPVRELAAVP | PELTGSRQSF | QKAMGNPCEF | FVDIM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Dishevelled-1
ELISA Kit for Human Dishevelled-1
ELISA Kit for Human Dishevelled-1
CLIA Kit for Human Dishevelled-1
CLIA Kit for Human Dishevelled-1
CLIA Kit for Human Dishevelled-1
Polyclonal Antibody for Human Dishevelled-1
Polyclonal Antibody for Human Dishevelled-1
Polyclonal Antibody for Human Dishevelled-1
Monoclonal Antibody for Human Dishevelled-1
Monoclonal Antibody for Human Dishevelled-1
Monoclonal Antibody for Human Dishevelled-1
Protein for Human Dishevelled-1
Protein for Human Dishevelled-1
Protein for Human Dishevelled-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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