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Index > Protein center > DVL1(Gene name) > Human
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  • DVL1 (Gene name),
  • Segment polarity protein dishevelled homolog DVL-1 (Protein name ),  DVL1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DVL1;
    Protein name:
    Segment polarity protein dishevelled homolog DVL-1(Dishevelled-1);
    Alternative:
    DSH homolog 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD (By similarity). Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site.
    Function:
    Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytosol Cytoplasmic vesicle Localizes at the cell membrane upon interaction with frizzled family members.
    Protein Attributes:
    Sequence length:
    695
    Sequence:
    50:
    MAETKIIYHM | DEEETPYLVK | LPVAPERVTL | ADFKNVLSNR | PVHAYKFFFK | 
    100:
    SMDQDFGVVK | EEIFDDNAKL | PCFNGRVVSW | LVLAEGAHSD | AGSQGTDSHT | 
    150:
    DLPPPLERTG | GIGDSRPPSF | HPNVASSRDG | MDNETGTESM | VSHRRERARR | 
    200:
    RNREEAARTN | GHPRGDRRRD | VGLPPDSAST | ALSSELESSS | FVDSDEDGST | 
    250:
    SRLSSSTEQS | TSSRLIRKHK | RRRRKQRLRQ | ADRASSFSSI | TDSTMSLNIV | 
    300:
    TVTLNMERHH | FLGISIVGQS | NDRGDGGIYI | GSIMKGGAVA | ADGRIEPGDM | 
    350:
    LLQVNDVNFE | NMSNDDAVRV | LREIVSQTGP | ISLTVAKCWD | PTPRSYFTVP | 
    400:
    RADPVRPIDP | AAWLSHTAAL | TGALPRYGTS | PCSSAVTRTS | SSSLTSSVPG | 
    450:
    APQLEEAPLT | VKSDMSAVVR | VMQLPDSGLE | IRDRMWLKIT | IANAVIGADV | 
    500:
    VDWLYTHVEG | FKERREARKY | ASSLLKHGFL | RHTVNKITFS | EQCYYVFGDL | 
    550:
    CSNLATLNLN | SGSSGTSDQD | TLAPLPHPAA | PWPLGQGYPY | QYPGPPPCFP | 
    600:
    PAYQDPGFSY | GSGSTGSQQS | EGSKSSGSTR | SSRRAPGREK | ERRAAGAGGS | 
    650:
    GSESDHTAPS | GVGSSWRERP | AGQLSRGSSP | RSQASATAPG | LPPPHPTTKA | 
    695:
    YTVVGGPPGG | PPVRELAAVP | PELTGSRQSF | QKAMGNPCEF | FVDIM
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    SMR:
    Pfam:
    UniGene:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Dishevelled-1
    Cat.:
    E15104h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Dishevelled-1
    MSDS:
    Please sign in first.
    ELISA Kit for Human Dishevelled-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Dishevelled-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Dishevelled-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Dishevelled-1
    Cat.:
    U15104h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Dishevelled-1
    Polyclonal Antibody for Human Dishevelled-1
    Polyclonal Antibody for Human Dishevelled-1
    Monoclonal Antibody for Human Dishevelled-1
    Monoclonal Antibody for Human Dishevelled-1
    Monoclonal Antibody for Human Dishevelled-1
    Protein for Human Dishevelled-1
    Protein for Human Dishevelled-1
    Protein for Human Dishevelled-1

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    Precision
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    Linearity
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    References
    1. 1.
      "Human dishevelled genes constitute a DHR-containing multigene family."
      Semenov M.V. , Snyder M.
      Genomics42:302-310(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins."
      Chen W. , Hu L.A. , Semenov M.V. , Yanagawa S. , Kikuchi A. , Lefkowitz R.J. , Miller W.E.
      Proc. Natl. Acad. Sci. U.S.A.98:14889-14894(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB1
    4. 4.
      "Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway."
      Oshita A. , Kishida S. , Kobayashi H. , Michiue T. , Asahara T. , Asashima M. , Kikuchi A.
      Genes Cells8:1005-1017(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCDC88C
    5. 5.
      "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth."
      Lu W. , Yamamoto V. , Ortega B. , Baltimore D.
      Cell119:97-108(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RYK
    6. 6.
      "Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways."
      Simons M. , Gloy J. , Ganner A. , Bullerkotte A. , Bashkurov M. , Kroenig C. , Schermer B. , Benzing T. , Cabello O.A. , Jenny A. , Mlodzik M. , Polok B. , Driever W. , Obara T. , Walz G.
      Nat. Genet.37:537-543(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INVS
    7. 7.
      "Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein."
      Lee H.J. , Finkelstein D. , Li X. , Wu D. , Shi D.L. , Zheng J.J.
      J. Biol. Chem.285:41549-41556(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMEM88
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