DNM2 ELISA Kit for Human(Homo sapiens) | EIAab.comDNM2 ELISA Kit for Human(Homo sapiens)

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DNM2 (Gene name),

Dynamin-2 (Protein name ), DYN2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

DNM2(DYN2);

Protein name:

Dynamin-2;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MYOF (By similarity). Interacts with SHANK1, SHANK2, SH3BP4 and NOSTRIN. Interacts with SNX9.

Function:

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.

Subcellular Location:

Cytoplasm Cytoplasm cytoskeleton Cell junction synapse postsynaptic cell membrane postsynaptic density Cell junction synapse Microtubule-associated. Also found in the postsynaptic density of neuronal cells.

Protein Attributes:

Sequence length:

870

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

870:

PPAAPSRPTI | IRPAEPSLLD |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

160150

SMR:

P50570

UniGene:

Hs.211463

String:

P50570

STRING:

9606.ENSP00000352721

KEGG:

hsa:1785

Pfam:

PF01031

Uniprot:

P50570

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ELISA Kit for Human Dynamin-2

Cat.:

E1164h

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96T

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ELISA Kit for Human Dynamin-2

Cat.:

E1164m

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96T

ELISA Kit for Human Dynamin-2

Cat.:

E1164b

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96T

ELISA Kit for Human Dynamin-2

Cat.:

E1164r

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96T

CLIA Kit for Human Dynamin-2

Cat.:

U1164h

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96T

CLIA Kit for Human Dynamin-2

Cat.:

U1164b

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96T

CLIA Kit for Human Dynamin-2

Cat.:

U1164r

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96T

CLIA Kit for Human Dynamin-2

Cat.:

U1164m

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96T

Polyclonal Antibody for Human Dynamin-2

Cat.:

P1164Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Dynamin-2

Cat.:

P1164Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Dynamin-2

Cat.:

P1164Rb-h

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Monoclonal Antibody for Human Dynamin-2

Protein for Human Dynamin-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"The Rise and the Fall of Betatrophin/ANGPTL8 as an Inducer of β-Cell Proliferation"

Abu-Farha M, Al Madhoun A, Abubaker J.

From:Journal of Diabetes Research

References

1.

"Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family."
Diatloff-Zito C. , Gordon A.J.E. , Duchaud E. , Merlin G.
Gene163:301-306(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5)
tissue: Astrocyte.
tissue: Brain.
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Ovary.
tissue: Uterus.
5.

"Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton."
Okamoto P.M. , Gamby C. , Wells D. , Fallon J. , Vallee R.B.
J. Biol. Chem.276:48458-48465(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHANK PROTEINS
6.

"The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis."
Thompson H.M. , Skop A.R. , Euteneuer U. , Meyer B.J. , McNiven M.A.
Curr. Biol.12:2111-2117(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOKINESIS;SUBCELLULAR LOCATION
7.

"TTP specifically regulates the internalization of the transferrin receptor."
Tosoni D. , Puri C. , Confalonieri S. , Salcini A.E. , De Camilli P. , Tacchetti C. , Di Fiore P.P.
Cell123:875-888(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH3BP4
8.

"NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS."
Icking A. , Matt S. , Opitz N. , Wiesenthal A. , Mueller-Esterl W. , Schilling K.
J. Cell Sci.118:5059-5069(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOSTRIN
9.

"SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis."
Soulet F. , Yarar D. , Leonard M. , Schmid S.L.
Mol. Biol. Cell16:2058-2067(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH SNX9
10.

"Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis."
Krendel M. , Osterweil E.K. , Mooseker M.S.
FEBS Lett.581:644-650(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYO1E
11.

"A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein."
Schobel S. , Neumann S. , Hertweck M. , Dislich B. , Kuhn P.H. , Kremmer E. , Seed B. , Baumeister R. , Haass C. , Lichtenthaler S.F.
J. Biol. Chem.283:14257-14268(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX33
12.

"The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration."
Cooper K.M. , Bennin D.A. , Huttenlocher A.
Mol. Biol. Cell19:3180-3191(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSTPIP1
13.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
15.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-598;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Solution structure of the PH domain of dynamin-2 from human."
RIKEN structural genomics initiative (RSGI)
Submitted (2008-04) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 514-625
19.

"Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease."
Zuechner S. , Noureddine M. , Kennerson M. , Verhoeven K. , Claeys K. , De Jonghe P. , Merory J. , Oliveira S.A. , Speer M.C. , Stenger J.E. , Walizada G. , Zhu D. , Pericak-Vance M.A. , Nicholson G. , Timmerman V. , Vance J.M.
Nat. Genet.37:289-294(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMTDIB 555-ASP--GLU-557 DEL; LYS-562 DEL AND GLU-562;CHARACTERIZATION OF VARIANT CMTDIB 555-ASP--GLU-557 DEL
20.

"Mutations in dynamin 2 cause dominant centronuclear myopathy."
Bitoun M. , Maugenre S. , Jeannet P.-Y. , Lacene E. , Ferrer X. , Laforet P. , Martin J.-J. , Laporte J. , Lochmueller H. , Beggs A.H. , Fardeau M. , Eymard B. , Romero N.B. , Guicheney P.
Nat. Genet.37:1207-1209(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CNM1 LYS-368; TRP-369; GLN-369 AND TRP-465;CHARACTERIZATION OF VARIANTS CNM1 TRP-369 AND TRP-465
21.

"Dynamin 2 mutations cause sporadic centronuclear myopathy with neonatal onset."
Bitoun M. , Bevilacqua J.A. , Prudhon B. , Maugenre S. , Taratuto A.L. , Monges S. , Lubieniecki F. , Cances C. , Uro-Coste E. , Mayer M. , Fardeau M. , Romero N.B. , Guicheney P.
Ann. Neurol.62:666-670(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CNM1 THR-618; LEU-619; TRP-619 AND VAL-625 DEL
22.

"Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease."
Fabrizi G.M. , Ferrarini M. , Cavallaro T. , Cabrini I. , Cerini R. , Bertolasi L. , Rizzuto N.
Neurology69:291-295(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMT2M CYS-537 AND HIS-570
23.

"Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation."
Echaniz-Laguna A. , Nicot A.S. , Carre S. , Franques J. , Tranchant C. , Dondaine N. , Biancalana V. , Mandel J.L. , Laporte J.
Neuromuscul. Disord.17:955-959(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CNM1 GLN-368
24.

"Magnetic resonance imaging findings of leg musculature in Charcot-Marie-Tooth disease type 2 due to dynamin 2 mutation."
Gallardo E. , Claeys K.G. , Nelis E. , Garcia A. , Canga A. , Combarros O. , Timmerman V. , De Jonghe P. , Berciano J.
J. Neurol.255:986-992(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMT2M ARG-358
25.

"Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis."
Bitoun M. , Durieux A.-C. , Prudhon B. , Bevilacqua J.A. , Herledan A. , Sakanyan V. , Urtizberea A. , Cartier L. , Romero N.B. , Guicheney P.
Hum. Mutat.30:1419-1427(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CNM1 LYS-650;CHARACTERIZATION OF VARIANTS CNM1 TRP-465; VAL-625 DEL AND LYS-650;CHARACTERIZATION OF VARIANT CMTDIB GLU-562;PATHOPHYSIOLOGICAL PATHWAY IN THE AUTOSOMAL FORMS OF CNM AND DNM2-CMT NEUROPATHY
26.

"A new centronuclear myopathy phenotype due to a novel dynamin 2 mutation."
Bitoun M. , Bevilacqua J.A. , Eymard B. , Prudhon B. , Fardeau M. , Guicheney P. , Romero N.B.
Neurology72:93-95(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CNM1 LYS-560
27.

"Centronuclear myopathy with cataracts due to a novel dynamin 2 (DNM2) mutation."
Jungbluth H. , Cullup T. , Lillis S. , Zhou H. , Abbs S. , Sewry C. , Muntoni F.
Neuromuscul. Disord.20:49-52(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CNM1 PRO-621
28.

"Adult course in dynamin 2 dominant centronuclear myopathy with neonatal onset."
Melberg A. , Kretz C. , Kalimo H. , Wallgren-Pettersson C. , Toussaint A. , Bohm J. , Stalberg E. , Laporte J.
Neuromuscul. Disord.20:53-56(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CNM1 ASP-618
29.

"Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy."
Susman R.D. , Quijano-Roy S. , Yang N. , Webster R. , Clarke N.F. , Dowling J. , Kennerson M. , Nicholson G. , Biancalana V. , Ilkovski B. , Flanigan K.M. , Arbuckle S. , Malladi C. , Robinson P. , Vucic S. , Mayer M. , Romero N.B. , Urtizberea J.A. , more...
Neuromuscul. Disord.20:229-237(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CNM1 LYS-368; TRP-465; HIS-522; THR-618; LEU-619 AND HIS-627
30.

"Mutation spectrum in the large GTPase dynamin 2, and genotype-phenotype correlation in autosomal dominant centronuclear myopathy."
Bohm J. , Biancalana V. , Dechene E.T. , Bitoun M. , Pierson C.R. , Schaefer E. , Karasoy H. , Dempsey M.A. , Klein F. , Dondaine N. , Kretz C. , Haumesser N. , Poirson C. , Toussaint A. , Greenleaf R.S. , Barger M.A. , Mahoney L.J. , Kang P.B. , more...
Hum. Mutat.33:949-959(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CNM1 CYS-522; GLY-523 AND ARG-627
31.

"Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome."
Koutsopoulos O.S. , Kretz C. , Weller C.M. , Roux A. , Mojzisova H. , Boehm J. , Koch C. , Toussaint A. , Heckel E. , Stemkens D. , Ter Horst S.A. , Thibault C. , Koch M. , Mehdi S.Q. , Bijlsma E.K. , Mandel J.L. , Vermot J. , Laporte J.
Eur. J. Hum. Genet.21:637-642(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LCCS5 VAL-379

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