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Index > Protein center > ECM1(Gene name) > Human
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  • ECM1 (Gene name),
  • Extracellular matrix protein 1 (Protein name ),  ECM1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ECM1;
    Protein name:
    Extracellular matrix protein 1;
    Alternative:
    Secretory component p85;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via C-terminus) with HSPG2 (via C-terminus). Interacts with EFEMP1/FBLN3 and LAMB3. Interacts with MMP9.
    Function:
    Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    540
    Sequence:
    50:
    MGTTARAALV | LTYLAVASAA | SEGGFTATGQ | RQLRPEHFQE | VGYAAPPSPP | 
    100:
    LSRSLPMDHP | DSSQHGPPFE | GQSQVQPPPS | QEATPLQQEK | LLPAQLPAEK | 
    150:
    EVGPPLPQEA | VPLQKELPSL | QHPNEQKEGT | PAPFGDQSHP | EPESWNAAQH | 
    200:
    CQQDRSQGGW | GHRLDGFPPG | RPSPDNLNQI | CLPNRQHVVY | GPWNLPQSSY | 
    250:
    SHLTRQGETL | NFLEIGYSRC | CHCRSHTNRL | ECAKLVWEEA | MSRFCEAEFS | 
    300:
    VKTRPHWCCT | RQGEARFSCF | QEEAPQPHYQ | LRACPSHQPD | ISSGLELPFP | 
    350:
    PGVPTLDNIK | NICHLRRFRS | VPRNLPATDP | LQRELLALIQ | LEREFQRCCR | 
    400:
    QGNNHTCTWK | AWEDTLDKYC | DREYAVKTHH | HLCCRHPPSP | TRDECFARRA | 
    450:
    PYPNYDRDIL | TIDIGRVTPN | LMGHLCGNQR | VLTKHKHIPG | LIHNMTARCC | 
    500:
    DLPFPEQACC | AEEEKLTFIN | DLCGPRRNIW | RDPALCCYLS | PGDEQVNCFN | 
    540:
    INYLRNVALV | SGDTENAKGQ | GEQGSTGGTN | ISSTSEPKEE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    MIM:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Extracellular matrix protein 1
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    E1864m
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    Packing:
    96T
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    ELISA Kit for Human Extracellular matrix protein 1
    Cat.:
    E1864h
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    96T
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    ELISA Kit for Human Extracellular matrix protein 1
    Cat.:
    E1864r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Extracellular matrix protein 1
    Cat.:
    U1864h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Extracellular matrix protein 1
    Cat.:
    U1864r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Extracellular matrix protein 1
    Cat.:
    U1864m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Extracellular matrix protein 1
    Cat.:
    P1864Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Extracellular matrix protein 1
    Cat.:
    P1864Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Extracellular matrix protein 1
    Cat.:
    P1864Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Extracellular matrix protein 1
    Monoclonal Antibody for Human Extracellular matrix protein 1
    Monoclonal Antibody for Human Extracellular matrix protein 1
    Protein for Human Extracellular matrix protein 1
    Protein for Human Extracellular matrix protein 1
    Protein for Human Extracellular matrix protein 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization."
      Smits P. , Ni J. , Feng P. , Wauters J. , van Hul W. , Boutaibi M.E. , Dillon P.J. , Merregaert J.
      Genomics45:487-495(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);VARIANT SER-415
    2. 2.
      "Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21."
      Johnson M.R. , Wilkin D.J. , Vos H.L. , Ortiz de Luna R.I. , Dehejia A.M. , Polymeropoulos M.H. , Francomano C.A.
      Matrix Biol.16:289-292(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4);VARIANTS MET-130 AND SER-415
      tissue: Synovial cell.
      tissue: Testis.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS MET-130 AND SER-415
      tissue: Skin.
    7. 7.
      "Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro."
      Deckers M.M.L. , Smits P. , Karperien M. , Ni J. , Tylzanowski P. , Feng P. , Parmelee D. , Zhang J. , Bouffard E. , Gentz R. , Loewik C.W.G.M. , Merregaert J.
      Bone28:14-20(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN BONE FORMATION
    8. 8.
      "Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells."
      Han Z. , Ni J. , Smits P. , Underhill C.B. , Xie B. , Chen Y. , Liu N. , Tylzanowski P. , Parmelee D. , Feng P. , Ding I. , Gao F. , Gentz R. , Huylebroeck D. , Merregaert J. , Zhang L.
      FASEB J.15:988-994(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS;TISSUE SPECIFICITY
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LIPOID PROTEINOSIS
    10. 10.
      "Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis."
      Mongiat M. , Fu J. , Oldershaw R. , Greenhalgh R. , Gown A.M. , Iozzo R.V.
      J. Biol. Chem.278:17491-17499(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HSPG2;TISSUE SPECIFICITY
    11. 11.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-444
      tissue: Plasma.
    12. 12.
      "Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions."
      Fujimoto N. , Terlizzi J. , Aho S. , Brittingham R. , Fertala A. , Oyama N. , McGrath J.A. , Uitto J.
      Exp. Dermatol.15:300-307(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MMP9;FUNCTION
    13. 13.
      "ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain."
      Sercu S. , Lambeir A.M. , Steenackers E. , El Ghalbzouri A. , Geentjens K. , Sasaki T. , Oyama N. , Merregaert J.
      Matrix Biol.28:160-169(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EFEMP1 AND LAMB3
    14. 14.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-444
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LIP ILE-167;VARIANTS MET-130 AND SER-415
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