Protein name:
Extracellular matrix protein 1 ;
Alternative:
Secretory component p85 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via C-terminus) with HSPG2 (via C-terminus). Interacts with EFEMP1/FBLN3 and LAMB3. Interacts with MMP9.
Function:
Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MGTTARAALV | LTYLAVASAA | SEGGFTATGQ | RQLRPEHFQE | VGYAAPPSPP |
100:
LSRSLPMDHP | DSSQHGPPFE | GQSQVQPPPS | QEATPLQQEK | LLPAQLPAEK |
150:
EVGPPLPQEA | VPLQKELPSL | QHPNEQKEGT | PAPFGDQSHP | EPESWNAAQH |
200:
CQQDRSQGGW | GHRLDGFPPG | RPSPDNLNQI | CLPNRQHVVY | GPWNLPQSSY |
250:
SHLTRQGETL | NFLEIGYSRC | CHCRSHTNRL | ECAKLVWEEA | MSRFCEAEFS |
300:
VKTRPHWCCT | RQGEARFSCF | QEEAPQPHYQ | LRACPSHQPD | ISSGLELPFP |
350:
PGVPTLDNIK | NICHLRRFRS | VPRNLPATDP | LQRELLALIQ | LEREFQRCCR |
400:
QGNNHTCTWK | AWEDTLDKYC | DREYAVKTHH | HLCCRHPPSP | TRDECFARRA |
450:
PYPNYDRDIL | TIDIGRVTPN | LMGHLCGNQR | VLTKHKHIPG | LIHNMTARCC |
500:
DLPFPEQACC | AEEEKLTFIN | DLCGPRRNIW | RDPALCCYLS | PGDEQVNCFN |
540:
INYLRNVALV | SGDTENAKGQ | GEQGSTGGTN | ISSTSEPKEE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Extracellular matrix protein 1
ELISA Kit for Human Extracellular matrix protein 1
ELISA Kit for Human Extracellular matrix protein 1
CLIA Kit for Human Extracellular matrix protein 1
CLIA Kit for Human Extracellular matrix protein 1
CLIA Kit for Human Extracellular matrix protein 1
Polyclonal Antibody for Human Extracellular matrix protein 1
Polyclonal Antibody for Human Extracellular matrix protein 1
Polyclonal Antibody for Human Extracellular matrix protein 1
Monoclonal Antibody for Human Extracellular matrix protein 1
Monoclonal Antibody for Human Extracellular matrix protein 1
Monoclonal Antibody for Human Extracellular matrix protein 1
Protein for Human Extracellular matrix protein 1
Protein for Human Extracellular matrix protein 1
Protein for Human Extracellular matrix protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);VARIANT SER-415
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
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Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4);VARIANTS MET-130 AND SER-415
tissue :
Synovial cell .
tissue :
Testis .
4.
"The DNA sequence and biological annotation of human chromosome 1."
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS MET-130 AND SER-415
tissue :
Skin .
7.
"Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro."
Deckers M.M.L.
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Smits P.
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Karperien M.
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Bone28:14-20(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN BONE FORMATION
8.
"Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells."
Han Z.
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Ni J.
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Underhill C.B.
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Xie B.
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FASEB J.15:988-994(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN ANGIOGENESIS;TISSUE SPECIFICITY
9.
"Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1)."
Hamada T.
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more...
Hum. Mol. Genet.11:833-840(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN LIPOID PROTEINOSIS
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HSPG2;TISSUE SPECIFICITY
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-444
tissue :
Plasma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MMP9;FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EFEMP1 AND LAMB3
14.
"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W.
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Chi H.
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Yuan Z.F.
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Zheng Z.B.
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Song L.N.
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,
Qian X.H.
Mol. Cell. Proteomics8:913-923(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : GLYCOSYLATION AT ASN-444
15.
"Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation."
Hamada T.
,
Wessagowit V.
,
South A.P.
,
Ashton G.H.S.
,
Chan I.
,
Oyama N.
,
Siriwattana A.
,
Jewhasuchin P.
,
Charuwichitratana S.
,
Thappa D.M.
,
Lenane P.
,
Krafchik B.
,
Kulthanan K.
,
Shimizu H.
,
Kaya T.I.
,
Erdal M.E.
,
Paradisi M.
,
Paller A.S.
,
Seishima M.
,
Hashimoto T.
,
McGrath J.A.
more...
J. Invest. Dermatol.120:345-350(2003)
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PubMed ]
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Europe PMC ]
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Abstract ]
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Cited for : VARIANT LIP ILE-167;VARIANTS MET-130 AND SER-415