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Index > Protein center > Egf(Gene name) > Rat
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  • Egf (Gene name),
  • Pro-epidermal growth factor (Protein name ),  EGF_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Egf;
    Protein name:
    Pro-epidermal growth factor(EGF);
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity). Interacts with RHBDF2.
    Function:
    EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1133
    Sequence:
    50:
    MLFSLTFLSV | FLKITVLSVT | AQQTRNCQSG | PLERSGTTTY | AAAGPPRFLI | 
    100:
    FLQGNSIFRI | NTDGTNHQQL | VVDAGVSVVM | DFHYKEERLY | WVDLERQLLQ | 
    150:
    RVFFNGSGQE | TVCKVDKNVS | GLAINWIDGE | ILRTDRWKGV | ITVTDMNGNN | 
    200:
    SRVLLSSLKR | PANILVDPTE | RLIFWSSVVT | GNLHRADLGG | MDVKTLLEAP | 
    250:
    ERISVLILDI | LDKRLFWAQD | GREGSHGYIH | SCDYNGGSIH | HIRHQARHDL | 
    300:
    LTMAIFGDKI | LYSALKEKAI | WIADKHTGKN | VVRVNLDPAS | VPPRELRVVH | 
    350:
    LHAQPGTENR | AQASDSERCK | QRRGQCLYSL | SERDPNSDSS | ACAEGYTLSR | 
    400:
    DRKYCEDVNE | CALQNHGCTL | GCENIPGSYY | CTCPTGFVLL | PDGKRCHELV | 
    450:
    ACPGNRSECS | HDCILTSDGP | LCICPAGSVL | GKDGKTCTGC | SFSDNGGCSQ | 
    500:
    ICLPLSLASW | ECDCFPGYDL | QLDRKSCAAS | MGPQPFLLFA | NSQDIRHMHF | 
    550:
    DGTDYKTLLS | RQMGMVFALD | YDPVESKIYF | AQTALKWIER | ANLDGSQRER | 
    600:
    RITEGVDTPE | GLAVDWIGRR | IYWTDSGKSV | IEGSDLSGKH | HQIIIKESIS | 
    650:
    RPRGIAVHPK | ARRLFWTDTG | MSPRIESSSL | QGSDRTLIAS | SNLLEPSGIA | 
    700:
    IDYLTDTLYW | CDTKLSVIEM | ADLDGSKRRR | LTQNDVGHPF | SLAVFEDHVW | 
    750:
    FSDWAIPSVI | RVNKRTGQNR | VRLRGSMLKP | SSLVVVHPLA | KPGADPCLHR | 
    800:
    NGGCEHICQE | SLGTAQCLCR | EGFVKAPDGK | MCLTRKDDQI | LAGDNADLSK | 
    850:
    EVASLDNSPK | AYVPDDDRTE | SSTLVAEIMV | SGLNYEDDCG | PGGCGSHAHC | 
    900:
    ISEGEAAVCQ | CLKGFAGDGN | LCSDIDECEL | GSSDCPPTSS | RCINTEGGYV | 
    950:
    CQCSEGYEGD | GIYCLDVDEC | QQGSHGCSEN | ATCTNTEGGY | NCTCAGCPSA | 
    1000:
    PGLPCPDSTS | PSLLGKDGCH | WVRNSNTGCP | PSYDGYCLNG | GVCMYVESVD | 
    1050:
    RYVCNCVIGY | IGERCQHRDL | RWWKLRHADY | GQRHDITVVS | VCVVALALLL | 
    1100:
    LLGMWGTYYY | RTRKQLSESS | KKPSEESSSN | VSSNGPDSSG | AGVSSGPQPW | 
    1133:
    FVVLEEHQQP | KNGRLPAAGT | NGAVVEAGLS | SSL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
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    CLIA Kit for Rat EGF
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    CLIA Kit for Rat EGF
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    CLIA Kit for Rat EGF
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    U0560d
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    Polyclonal Antibody for Rat EGF
    Polyclonal Antibody for Rat EGF
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    P0560Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat EGF
    Polyclonal Antibody for Rat EGF
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    Packing:
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    Polyclonal Antibody for Rat EGF
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    P0560Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat EGF
    Monoclonal Antibody for Rat EGF
    Monoclonal Antibody for Rat EGF
    Monoclonal Antibody for Rat EGF
    Monoclonal Antibody for Rat EGF
    Protein for Rat EGF
    Protein for Rat EGF
    Protein for Rat EGF
    Protein for Rat EGF
    Protein for Rat EGF

    R&D Technical Data
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    Precision

    Intra-Assay CV: ≤4.3

    Inter-Assay CV: ≤7.5

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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and sequencing of the rat preproepidermal growth factor cDNA: comparison with mouse and human sequences."
      Price P.M. , Saggi S.J. , Safirstein R.
      DNA Cell Biol.11:481-487(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Kidney.
    2. 2.
      Price P.M.
      Submitted (1994-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
      tissue: Kidney.
    3. 3.
      "Rat epidermal growth factor: complete amino acid sequence. Homology with the corresponding murine and human proteins; isolation of a form truncated at both ends with full in vitro biological activity."
      Simpson R.J. , Smith J.A. , Moritz R.L. , O'Hare M.J. , Rudland P.S. , Morrison J.R. , Lloyd C.J. , Grego B. , Burgess A.W. , Nice E.C.
      Eur. J. Biochem.153:629-637(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 974-1021
    4. 4.
      "Cloning and sequence analysis of a cDNA for rat epidermal growth factor."
      Dorow D.S. , Simpson R.J.
      Nucleic Acids Res.16:9338-9338(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 994-1133
      strain: Sprague-Dawley.
      tissue: Kidney.
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