EIF3A ELISA Kit for Human(Homo sapiens) | EIAab.comEIF3A ELISA Kit for Human(Homo sapiens)

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EIF3A (Gene name),

Eukaryotic translation initiation factor 3 subunit A (Protein name ), EIF3A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

EIF3A(EIF3S10;KIAA0139);

Protein name:

Eukaryotic translation initiation factor 3 subunit A(eIF3a);

Alternative:

eIF-3-theta;Eukaryotic translation initiation factor 3 subunit 10;eIF3 p180;eIF3 p167;eIF3 p185;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with EIF4G1 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2.

Function:

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1382

Sequence:

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1050:

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1150:

1200:

1250:

1300:

1350:

1382:

KEKASWRAEK | DRESLRRTKN | ETDEDGWTTV | RR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.523299

KEGG:

hsa:8661

STRING:

9606.ENSP00000358140

MIM:

602039

Pfam:

PF01399

String:

Q14152

Uniprot:

Q14152

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ELISA Kit for Human eIF3a

Cat.:

E1885h

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96T

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ELISA Kit for Human eIF3a

Cat.:

E1885r

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96T

ELISA Kit for Human eIF3a

Cat.:

E1885m

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96T

CLIA Kit for Human eIF3a

Cat.:

U1885m

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MSDS:

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Packing:

96T

CLIA Kit for Human eIF3a

Cat.:

U1885r

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MSDS:

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Packing:

96T

CLIA Kit for Human eIF3a

Cat.:

U1885h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human eIF3a

Cat.:

P1885Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human eIF3a

Cat.:

P1885Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human eIF3a

Cat.:

P1885Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human eIF3a

Protein for Human eIF3a

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The human p167 gene encodes a unique structural protein that contains centrosomin A homology and associates with a multicomponent complex."
Scholler J.K. , Kanner S.B.
DNA Cell Biol.16:515-531(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);SUBCELLULAR LOCATION
tissue: Lymphoblastoma.
2.

"Identification of cDNA clones for the large subunit of eukaryotic translation initiation factor 3. Comparison of homologues from human, Nicotiana tabacum, Caenorhabditis elegans, and Saccharomyces cerevisiae."
Johnson K.R. , Merrick W.C. , Zoll W.L. , Zhu Y.
J. Biol. Chem.272:7106-7113(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Keratinocyte.
tissue: Liver.
3.

"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T. , Seki N. , Tanaka A. , Ishikawa K. , Nomura N.
DNA Res.2:167-174(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Myelomonocyte.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT LYS-386
tissue: Testis.
5.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Bienvenut W.V. , Boldt K. , von Kriegsheim A.F. , Matallanas D. , Cooper W.N. , Kolch W.
Submitted (2007-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13; 15-36; 69-75; 85-91; 144-151; 173-183; 252-264; 279-298; 309-317; 322-335; 341-351; 368-388; 439-469; 490-546; 582-589; 624-632; 694-711; 719-740; 776-782; 817-824; 838-847; 850-856; 862-868; 877-885; 1071-1080; 1122-1130; 1142-1150 AND 1358-1366;CLEAVAGE OF INITIATOR METHIONINE;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Hepatoma.
tissue: Mammary carcinoma.
8.

"Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7."
Lin L. , Holbro T. , Alonso G. , Gerosa D. , Burger M.M.
J. Cell. Biochem.80:483-490(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EIF3B AND KRT7
9.

"Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3."
Mayeur G.L. , Fraser C.S. , Peiretti F. , Block K.L. , Hershey J.W.B.
Eur. J. Biochem.270:4133-4139(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF3B
10.

"The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro."
Fraser C.S. , Lee J.Y. , Mayeur G.L. , Bushell M. , Doudna J.A. , Hershey J.W.B.
J. Biol. Chem.279:8946-8956(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF3B
11.

"Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association."
Kolupaeva V.G. , Unbehaun A. , Lomakin I.B. , Hellen C.U.T. , Pestova T.V.
RNA11:470-486(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE EIF-3 COMPLEX
12.

"Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit."
LeFebvre A.K. , Korneeva N.L. , Trutschl M. , Cvek U. , Duzan R.D. , Bradley C.A. , Hershey J.W.B. , Rhoads R.E.
J. Biol. Chem.281:22917-22932(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE EIF-3 COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
13.

"Reconstitution reveals the functional core of mammalian eIF3."
Masutani M. , Sonenberg N. , Yokoyama S. , Imataka H.
EMBO J.26:3373-3383(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE EIF-3 COMPLEX
14.

"Human INT6/eIF3e is required for nonsense-mediated mRNA decay."
Morris C. , Wittmann J. , Jaeck H.-M. , Jalinot P.
EMBO Rep.8:596-602(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF3E
15.

"Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry."
Damoc E. , Fraser C.S. , Zhou M. , Videler H. , Mayeur G.L. , Hershey J.W.B. , Doudna J.A. , Robinson C.V. , Leary J.A.
Mol. Cell. Proteomics6:1135-1146(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE EIF-3 COMPLEX;CHARACTERIZATION OF THE EIF-3 COMPLEX;CLEAVAGE OF INITIATOR METHIONINE;PHOSPHORYLATION AT SER-881; SER-1198; SER-1336 AND SER-1364;MASS SPECTROMETRY
16.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3."
Zhou M. , Sandercock A.M. , Fraser C.S. , Ridlova G. , Stephens E. , Schenauer M.R. , Yokoi-Fong T. , Barsky D. , Leary J.A. , Hershey J.W.B. , Doudna J.A. , Robinson C.V.
Proc. Natl. Acad. Sci. U.S.A.105:18139-18144(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE EIF-3 COMPLEX;CHARACTERIZATION OF THE EIF-3 COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
18.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-492;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-882;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"Structural roles for human translation factor eIF3 in initiation of protein synthesis."
Siridechadilok B. , Fraser C.S. , Hall R.J. , Doudna J.A. , Nogales E.
Science310:1513-1515(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING;ELECTRON MICROSCOPY

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