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Index > Protein center > PI3(Gene name) > Human
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  • PI3 (Gene name),
  • Elafin (Protein name ),  ELAF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PI3(WAP3;WFDC14);
    Protein name:
    Elafin;
    Alternative:
    Peptidase inhibitor 3(PI-3);Elastase-specific inhibitor(ESI);Skin-derived antileukoproteinase(SKALP);Protease inhibitor WAP3;WAP four-disulfide core domain protein 14;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    117
    Sequence:
    50:
    MRASSFLIVV | VFLIAGTLVL | EAAVTGVPVK | GQDTVKGRVP | FNGQDPVKGQ | 
    100:
    VSVKGQDKVK | AQEPVKGPVS | TKPGSCPIIL | IRCAMLNPPN | RCLKDTDCPG | 
    117:
    IKKCCEGSCG | MACFVPQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    MIM:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Elafin
    Cat.:
    E1665h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Elafin
    Cat.:
    U1665h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Elafin
    Cat.:
    P1665Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Elafin
    Protein for Human Elafin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment."
      Saheki T. , Ito F. , Hagiwara H. , Saito Y. , Kuroki J. , Tachibana S. , Hirose S.
      Biochem. Biophys. Res. Commun.185:240-245(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking."
      Molhuizen H.O.F. , Alkemade H.A.C. , Zeeuwen P.L.J.M. , de Jongh G.J. , Wieringa B. , Schalkwijk J.
      J. Biol. Chem.268:12028-12032(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 23-48 AND 85-100
      tissue: Keratinocyte.
    3. 3.
      "Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions."
      Sallenave J.-M. , Silva A.
      Am. J. Respir. Cell Mol. Biol.8:439-445(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    8. 8.
      "Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence."
      Wiedow O. , Schroeder J.-M. , Gregory H. , Young J.A. , Christophers E.
      J. Biol. Chem.265:14791-14795(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 61-117
      tissue: Stratum corneum.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    10. 10.
      "Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor."
      Sallenave J.-M. , Ryle A.P.
      Biol. Chem. Hoppe-Seyler372:13-21(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 70-94
      tissue: Sputum.
    11. 11.
      "Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity."
      Sallenave J.-M. , Marsden M.D. , Ryle A.P.
      Biol. Chem. Hoppe-Seyler373:27-33(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 61-77
      tissue: Sputum.
    12. 12.
      "Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties."
      Schalkwijk J. , de Roo C. , de Jongh G.J.
      Biochim. Biophys. Acta1096:148-154(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 85-100
      tissue: Keratinocyte.
    13. 13.
      "Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9-A resolution."
      Tsunemi M. , Matsuura Y. , Sakakibara S. , Katsube Y.
      Biochemistry35:11570-11576(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
    14. 14.
      "Solution structure of R-elafin, a specific inhibitor of elastase."
      Francart C. , Dauchez M. , Alix A.J.P. , Lippens G.
      J. Mol. Biol.268:666-677(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
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