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Index > Protein center > IL12A(Gene name) > Human
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  • IL12A (Gene name),
  • Interleukin-12 subunit alpha (Protein name ),  IL12A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL12A(NKSF1);
    Protein name:
    Interleukin-12 subunit alpha(IL-12A);
    Alternative:
    NK cell stimulatory factor chain 1(NKSF1);Cytotoxic lymphocyte maturation factor 35 kDa subunit(CLMF p35);IL-12 subunit p35;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
    Function:
    Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    219
    Sequence:
    50:
    MCPARSLLLV | ATLVLLDHLS | LARNLPVATP | DPGMFPCLHH | SQNLLRAVSN | 
    100:
    MLQKARQTLE | FYPCTSEEID | HEDITKDKTS | TVEACLPLEL | TKNESCLNSR | 
    150:
    ETSFITNGSC | LASRKTSFMM | ALCLSSIYED | LKMYQVEFKT | MNAKLLMDPK | 
    200:
    RQIFLDQNML | AVIDELMQAL | NFNSETVPQK | SSLEEPDFYK | TKIKLCILLH | 
    219:
    AFRIRAVTID | RVMSYLNAS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    SMR:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-12A
    Cat.:
    E0059h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-12A
    Cat.:
    E0059m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-12A
    Cat.:
    E0059r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-12A
    Cat.:
    E0059d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-12A
    Cat.:
    E0059b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-12A
    Cat.:
    E0059p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-12A
    Cat.:
    U0059b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-12A
    Cat.:
    U0059h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-12A
    Cat.:
    U0059d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-12A
    Cat.:
    U0059m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-12A
    Cat.:
    U0059r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-12A
    Cat.:
    U0059p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human IL-12A
    Cat.:
    P0059Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-12A
    Cat.:
    P0059Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-12A
    Polyclonal Antibody for Human IL-12A
    Cat.:
    P0059Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-12A
    Polyclonal Antibody for Human IL-12A
    Monoclonal Antibody for Human IL-12A
    Monoclonal Antibody for Human IL-12A
    Monoclonal Antibody for Human IL-12A
    Monoclonal Antibody for Human IL-12A
    Monoclonal Antibody for Human IL-12A
    Monoclonal Antibody for Human IL-12A
    Protein for Human IL-12A
    Protein for Human IL-12A
    Protein for Human IL-12A
    Protein for Human IL-12A
    Protein for Human IL-12A
    Protein for Human IL-12A

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    References
    1. 1.
      "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells."
      Wolf S.F. , Temple P.A. , Kobayashi M. , Young D. , Dicig M. , Lowe L. , Dzialo R. , Fitz L. , Ferenz C. , Hewick R.M. , Kelleher K. , Herrmann S.H. , Clark S.C. , Azzoni L. , Chan S.H. , Trinchieri G. , Perussia B.
      J. Immunol.146:3074-3081(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor."
      Gubler U. , Chua A.O. , Schoenhaut D.S. , Dwyer C.M. , McComas W. , Motyka R. , Nabavi N. , Wolitzky A.G. , Quinn P.M. , Familletti P.C. , Gately M.K.
      Proc. Natl. Acad. Sci. U.S.A.88:4143-4147(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells."
      Stern A.S. , Podlaski F.J. , Hulmes J.D. , Pan Y.C.E. , Quinn P.M. , Wolitzky A.G. , Familletti P.C. , Stremlo D.L. , Truitt T. , Chizzonite R. , Gately M.K.
      Proc. Natl. Acad. Sci. U.S.A.87:6808-6812(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-48
    6. 6.
      "Sequence similarity between NKSF and the IL-6/G-CSF family."
      Merberg D.M. , Wolf S.F. , Clark S.C.
      Immunol. Today13:77-78(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIMILARITY TO IL-6
    7. 7.
      "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
      Leong W.F. , Chow V.T.
      Cell. Microbiol.8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;IDENTIFICATION BY MASS SPECTROMETRY
    8. 8.
      "Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12."
      Yoon C. , Johnston S.C. , Tang J. , Stahl M. , Tobin J.F. , Somers W.S.
      EMBO J.19:3530-3541(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 23-219;DISULFIDE BONDS
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