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Index > Protein center > Ubr4(Gene name) > Mouse
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  • Ubr4 (Gene name),
  • E3 ubiquitin-protein ligase UBR4 (Protein name ),  UBR4_MOUSE from NCBI database.
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  • Antigen Annotation
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  • Gene name:
    Ubr4(Kiaa0462;Zubr1);
    Protein name:
    E3 ubiquitin-protein ligase UBR4;
    Alternative:
    Zinc finger UBR1-type protein 1;N-recognin-4;p600;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with RB1 and calmodulin.
    Function:
    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions.
    Subcellular Location:
    Membrane Multi-pass membrane protein Cytoplasm Cytoplasm cytoskeleton Nucleus Concentrates at the leading edge of membrane structures involved in actin motility.
    Protein Attributes:
    Sequence length:
    5180
    Sequence:
    50:
    MATSGGEEAA | AAAPAPGAPA | TGQDTTPGWE | VAVRPLLSAS | YSAFEMKELP | 
    100:
    QLVASVIESE | SEILHHEKQY | EPFYSSFVAL | STHYITTVCS | LIPRNQLQSV | 
    150:
    AAACKVLIEF | SLLRLENPDE | ACAVSQKHLI | LLIKGLCTGC | SRLDRTEIIT | 
    200:
    FTAMMKSAKL | PQTVKTLSDV | EDQKELASPV | SPELRQKEVQ | MNFLNQLTSV | 
    250:
    FNPRTVPSPP | ISPQALVEGE | NDEQSSPDQV | SAAKTKSVFI | AQNVASLQEL | 
    300:
    GGSEKLLRVC | LNLPYFLRYI | NRFQDAVVAN | SFFIMPATVA | DATAVRNGFH | 
    350:
    SLVIDVTMAL | DTLSLPVLEP | LNPSRLQDVT | VLSLSCLYAG | VSVATCMAIL | 
    400:
    HVGSAQQVRT | GSTSSKEDDY | ESDAATIVQK | CLEIYDMIGQ | AISSSRRAGG | 
    450:
    EHFQNFQLLG | AWCLLNSLFL | ILNLSPTALA | DKGKEKDPLA | ALRVRDILSR | 
    500:
    TKEGVGSPKL | GPGKGHQGFG | VLSVILANHA | IKLLASLFQD | LQVEALHKGW | 
    550:
    ETDGPPAVLS | IMAQSTSTQR | IQRLIDSVPL | TNLLLTLLST | SYRKACVLQR | 
    600:
    QRKGSMSSDA | SASTDSNTYY | EDDFSSTEED | SSQDDDSEPI | LGQWFEETIS | 
    650:
    PSKEKAAPPP | PPPPPPLESS | PRVKSPNKQA | SGEKGNILAS | RKDPELFSGL | 
    700:
    ASNILNFITT | SMLNSRNSFI | RSYLSASLSE | HHMATLASII | KEVDKDGLKG | 
    750:
    SSDEDFAAAL | YHFNHSLVTS | DLQSPNLQNT | LLQQLGVAPF | SEGPWPLYIH | 
    800:
    PQGLSVLSRL | LLIWQHKAGA | QGDPDVPECL | KVWDRFLTTM | KQNALQGVVP | 
    850:
    SETEDLNVEH | LQLLLLIFHS | FSEKGRRAIL | TMLVQSIQEL | SVNMEVQMRT | 
    900:
    APLILARLLL | IFDYLLHQYS | KAPVYLFEQV | QHNLLSPPFG | WASGSQDSSS | 
    950:
    RRANTPLYHG | FKEVEENWSK | HFSSDAAPQP | RFYCVLSTEA | SEEDLNRLDS | 
    1000:
    EACEVLFSKP | VKYDELYSSL | TTLLAAGSQL | DTTRRKEKKN | VTALEACALQ | 
    1050:
    YYFLILWRIL | GILPPSKTYM | NQLAMNSPEM | SECDILHTLR | WSSRLRISSY | 
    1100:
    VSWIKDHLIK | QGMKPEHAGS | LIELAASKCS | SVKYDVEIVE | EYFARQISSF | 
    1150:
    CSIDCTAVLQ | LHEIPSLQSI | YTLDAAVSKV | QVSLDEHFSK | MAAETDPHKS | 
    1200:
    SEITKNLLPA | TLQLIDTYAS | FTRAYLLQNL | NEEGSTEKPS | QEKLHGFAAV | 
    1250:
    LAIGSSRCKA | NTLGPTLVQN | LPSSVQSVCE | SWNNINTNEF | PNIGSWRNAF | 
    1300:
    ANDTIPSESY | ISAVQAAHLG | TLCGQSLPLA | ASLKHTLLSL | VRLTGDLIVW | 
    1350:
    SDEMNPAQVI | RTLLPLLLES | STESAAEISS | NSLERILGPA | ESDEFLARVY | 
    1400:
    EKLITGCYNI | LANHADPNSG | LDESILEECL | QYLEKQLESS | QARKAMEEFF | 
    1450:
    SDGGELVQIM | MATANEDLSA | KFCNRVLKFF | TKLFQLTEKS | PNPSLLHLCG | 
    1500:
    SLAQLACVEP | VRLQAWLTRM | TTSPPKDSDQ | LEVIQENRQL | LQLLTTYIVR | 
    1550:
    ENSQVGEGVC | AVLLGTLTPM | ATDMLANGDG | TGFPELMVVM | ATLASAGQGA | 
    1600:
    GHLQLHNAAV | DWLGRCKKYL | SQKNVVEKLN | ANVMHGKHVM | VLECTCHIMS | 
    1650:
    YLADVTNALS | QSNGQGPSHL | SVDGEERAIE | VDSDWVEELA | VEEEDSQAED | 
    1700:
    SDEDSLCNKL | CTFTITQKEF | MNQHWYHCHT | CKMVDGVGVC | TVCAKVCHKD | 
    1750:
    HEISYAKYGS | FFCDCGAKED | GSCLALVKRT | PSSGMSSTMK | ESAFQSEPRV | 
    1800:
    SESLVRHAST | SPADKAKVTI | SDGKVTDEEK | PKKSSLCRTV | EGCREELQNQ | 
    1850:
    ANFSFAPLVL | DMLSFLMDAI | QTNFQQASAV | GSSSRAQQAL | SELHTVDKGV | 
    1900:
    EMTDQLMVPT | LGSQEGAFEN | VRMNYSGDQG | QTIRQLISAH | VLRRVAMCVL | 
    1950:
    SSPHGRRQHL | AVSHEKGKIT | VLQLSALLKQ | ADSSKRKLTL | TRLASAPVPF | 
    2000:
    TVLSLTGNPC | KEDYLAVCGL | KDCHVLTFSS | SGSVSDHLVL | HPQLATGNFI | 
    2050:
    IKAVWLPGSQ | TELAIVTADF | VKIYDLSIDA | LSPTFYFLLP | SSKIRDVTFL | 
    2100:
    FNEEGKNIIV | IMSSAGYMYT | QLMEEASSAQ | QGPFYVTNVL | EINHEDLKDS | 
    2150:
    NSQVAGGGVS | VYYSHVLQML | FFSYSQGRSF | AATVSRSTLE | VLQLFPINIK | 
    2200:
    SSNGGSKTSP | ALCQWSEVMN | HPGLVCCVQQ | TTGVPLVVMV | KPGTFLIQEI | 
    2250:
    KTLPAKAKIQ | DMVAIRHTAC | NEQQRTTMIL | LCEDGSLRIY | MANVENTSYW | 
    2300:
    LQPSLQPSSV | ISIMKPVRKR | KTATITARTS | SQVTFPIDFF | EHNQQLTDVE | 
    2350:
    FGGNDLLQVY | NAQQIKHRLN | STGMYVANTK | PGGFTIEISN | NSSTMVMTGM | 
    2400:
    RIQIGTQAIE | RAPSYIEIFG | RTMQLNLSRS | RWFDFPFTRE | EALQADRKLS | 
    2450:
    LFIGASVDPA | GVTMIDAVKI | YGKTKEQFGW | PDEPPEDFPS | ASVSNICPPN | 
    2500:
    LNQSNGTGES | DSAAPATTSG | TVLERLVVSS | LEALESCFAV | GPIIEKERNK | 
    2550:
    HAAQELATLL | LSLPAPASVQ | QQSKSLLASL | HSSRSAYHSH | KDQALLSKAV | 
    2600:
    QCLNTSSKEG | KDLDPEVFQR | LVITARSIAV | TRPNNLVHFT | ESKLPQMETE | 
    2650:
    GADEGKEPQK | QEGDGCSFIT | QLVNHFWKLH | ASKPKNAFLA | PACLPGLTHI | 
    2700:
    EATVNALVDI | IHGYCTCELD | CINTASKIYM | QMLLCPDPAV | SFSCKQALIR | 
    2750:
    VLRPRNKRRH | VTLPSSPRSN | TPMGDKDDDD | DDDADEKMQS | SGIPDGGHIR | 
    2800:
    QESQEQSEVD | HGDFEMVSES | MVLETAENVN | NGNPSPLEAL | LAGAEGFPPM | 
    2850:
    LDIPPDADDE | TMVELAIALS | LQQDQQGSSS | SALGLQSLGL | SGQAPSSSSL | 
    2900:
    DAGTLSDTTA | SAPASDDEGS | TAATDGSTLR | TSPADHGGSV | GSESGGSAVD | 
    2950:
    SVAGEHSVSG | RSSAYGDATA | EGHPAGPGSV | SSSTGAISTA | TGHQEGDGSE | 
    3000:
    GEGEGEAEGD | VHTSNRLHMV | RLMLLERLLQ | TLPQLRNVGG | VRAIPYMQVI | 
    3050:
    LMLTTDLDGE | DEKDKGALDN | LLAQLIAELG | MDKKDVSKKN | ERSALNEVHL | 
    3100:
    VVMRLLSVFM | SRTKSGSKSS | ICESSSLISS | ATAAALLSSG | AVDYCLHVLK | 
    3150:
    SLLEYWKSQQ | SDEEPVAASQ | LLKPHTTSSP | PDMSPFFLRQ | YVKGHAADVF | 
    3200:
    EAYTQLLTEM | VLRLPYQIKK | IADTSSRIPP | PVFDHSWFYF | LSEYLMIQQT | 
    3250:
    PFVRRQVRKL | LLFICGSKEK | YRQLRDLHTL | DSHVRGIKKL | LEEQGIFLRA | 
    3300:
    SVVTASSGSA | LQYDTLISLM | EHLKACAEIA | AQRTINWQKF | CIKDDSVLYF | 
    3350:
    LLQVSFLVDE | GVSPVLLQLL | SCALCGSKVL | AALAASTGSS | SVASSSAPPA | 
    3400:
    ASSGQATTQS | KSSTKKSKKE | EKEKEKEGES | SGSQEDQLCT | ALVNQLNRFA | 
    3450:
    DKETLIQFLR | CFLLESNSSS | VRWQAHCLTL | HIYRNSNKAQ | QELLLDLMWS | 
    3500:
    IWPELPAYGR | KAAQFVDLLG | YFSLKTAQTE | KKLKEYSQKA | VEILRTQNHI | 
    3550:
    LTNHPNSNIY | NTLSGLVEFD | GYYLESDPCL | VCNNPEVPFC | YIKLSSIKVD | 
    3600:
    TRYTTTQQVV | KLIGSHTISK | VTVKIGDLKR | TKMVRTINLY | YNNRTVQAIV | 
    3650:
    ELKNKPARWH | KAKKVQLTPG | QTEVKIDLPL | PIVASNLMIE | FADFYENYQA | 
    3700:
    STETLQCPRC | SASVPANPGV | CGNCGENVYQ | CHKCRSINYD | EKDPFLCNAC | 
    3750:
    GFCKYARFDF | MLYAKPCCAV | DPIENEEDRK | KAVSNINTLL | DKADRVYHQL | 
    3800:
    MGHRPQLENL | LCKVNEAAPE | KPQEDSGTAG | GISSTSASVN | RYILQLAQEY | 
    3850:
    CGDCKNSFDE | LSKIIQKVFA | SRKELLEYDL | QQREAATKSS | RTSVQPTFTA | 
    3900:
    SQYRALSVLG | CGHTSSTKCY | GCASAVTEHC | ITLLRALATN | PALRHILVSQ | 
    3950:
    GLIRELFDYN | LRRGAAAIRE | EVRQLMCLLT | RDNPEATQQM | NDLIIGKVST | 
    4000:
    ALKGHWANPD | LASSLQYEML | LLTDSISKED | SCWELRLRCA | LSLFLMAVNI | 
    4050:
    KTPVVVENIT | LMCLRILQKL | IKPPAPTSKK | NKDVPVEALT | TVKPYCNEIH | 
    4100:
    AQAQLWLKRD | PKASYEAWKK | CLPIRGVDGN | GKSPSKSELH | RLYLTEKYVW | 
    4150:
    RWKQFLSRRG | KRTTPLDLKL | GHNNWLRQVL | FTPATQAARQ | AACTIVEALA | 
    4200:
    TVPSRKQQVL | DLLTSYLDEL | SVAGECAAEY | LALYQKLIAS | CHWKVYLAAR | 
    4250:
    GVLPYVGNLI | TKEIARLLAL | EEATLSTDLQ | QGYALKSLTG | LLSSFVEVES | 
    4300:
    IKRHFKSRLV | GTVLNGYLCL | RKLVLQRTKL | IDETQDMLLE | MLEDMTTGTE | 
    4350:
    SETKAFMAVC | IETAKRYNLD | DYRTPVFIFE | RLCSIIYPEE | NEVTEFFVTL | 
    4400:
    EKDPQQEDFL | QGRMPGNPYS | SNEPGIGPLM | RDIKNKICQD | CDLVALLEDD | 
    4450:
    SGMELLVNNK | IISLDLPVAE | VYKKVWCATN | EGEPMRIVYR | MRGLLGDATE | 
    4500:
    EFIESLDSTT | DEEEDEEEVY | RMAGVMAQCG | GLQCMLNRLA | GVKDFKQGRH | 
    4550:
    LLTVLLKLFS | YCVKVKVNRQ | QLVKLETNTL | NVMLGTLNLA | LVAEQESKDS | 
    4600:
    GGAAVAEQVL | SIMEIILDES | NAEPLSEDKG | NLLLTGDKDQ | LVMLLDQINS | 
    4650:
    TFVRSNPSVL | QGLLRIIPYL | SFGEVEKMQI | LVERFKPYCS | FEKYDEDHSG | 
    4700:
    DDKVFLDCFC | KIAAGIKNNS | NGHQLKDLIL | QKGITQNALD | YMKKHIPSAK | 
    4750:
    NLDADIWKKF | LSRPALPFIL | RLLRGLAMQH | PATQVLIGTD | SITSLHKLEQ | 
    4800:
    VSSDEGIGTL | AENLLEALRE | HPDVNKKIDA | ARRETRAEKK | RMAMAMRQKA | 
    4850:
    LGTLGMTTNE | KGQVVTKTAL | LKQMEELIEE | PGLTCCICRE | GYKFQPTKVL | 
    4900:
    GIYTFTKRVA | LEEMENKPRK | QQGYSTVSHF | NIVHYDCHLA | AVRLARGREE | 
    4950:
    WESAALQNAN | TKCNGLLPVW | GPHVPESAFA | TCLARHNTYL | QECTGQREPT | 
    5000:
    YQLNIHDIKL | LFLRFAMEQS | FSADTGGGGR | ESNIHLIPYI | IHTVLYVLNT | 
    5050:
    TRATSREEKN | LQGFLEQPKE | KWTESAFDVD | GPHYFTILAL | HVLPPEQWKA | 
    5100:
    IRVEILRRLL | VASHARAVAP | GGATRLTDKA | VKDYSAYRSS | LLFWALVDLI | 
    5150:
    YNMFKKVPTS | NTEGGWSCSL | AEYIRHNDMP | IYEAADKALK | TFQEEFMPVE | 
    5180:
    TFSEFLDAAG | LLSEITDPES | FLKDLLNSVP | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase UBR4
    Cat.:
    E0192h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse E3 ubiquitin-protein ligase UBR4
    Cat.:
    E0192m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse E3 ubiquitin-protein ligase UBR4
    Cat.:
    E0192r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase UBR4
    Cat.:
    U0192r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase UBR4
    Cat.:
    U0192m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase UBR4
    Cat.:
    U0192h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase UBR4
    Cat.:
    P0192Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase UBR4
    Cat.:
    P0192Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase UBR4
    Cat.:
    P0192Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase UBR4
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase UBR4
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase UBR4
    Protein for Mouse E3 ubiquitin-protein ligase UBR4
    Protein for Mouse E3 ubiquitin-protein ligase UBR4
    Protein for Mouse E3 ubiquitin-protein ligase UBR4

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-4461 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2599-5180 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Embryo.
      tissue: Head.
      tissue: Retina.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Hara Y. , Nagase T. , Ohara O. , Koga H.
      Submitted (2002-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1290-3369 (ISOFORM 3)
      tissue: Brain.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4020-5180
      strain: C57BL/6.
      strain: FVB/N-3.
      tissue: Brain.
      tissue: Eye.
      tissue: Mammary tumor.
    5. 5.
      "A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons."
      Tasaki T. , Mulder L.C.F. , Iwamatsu A. , Lee M.J. , Davydov I.V. , Varshavsky A. , Muesing M. , Kwon Y.T.
      Mol. Cell. Biol.25:7120-7136(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;IDENTIFICATION BY MASS SPECTROMETRY
    6. 6.
      "Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding."
      DeMasi J. , Huh K.-W. , Nakatani Y. , Muenger K. , Howley P.M.
      Proc. Natl. Acad. Sci. U.S.A.102:11486-11491(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
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