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Index > Protein center > PLAU(Gene name) > Human
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  • PLAU (Gene name),
  • Urokinase-type plasminogen activator (Protein name ),  UROK_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    PLAU;
    Protein name:
    Urokinase-type plasminogen activator(U-plasminogen activator;uPA);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR.
    Function:
    Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    431
    Sequence:
    50:
    MRALLARLLL | CVLVVSDSKG | SNELHQVPSN | CDCLNGGTCV | SNKYFSNIHW | 
    100:
    CNCPKKFGGQ | HCEIDKSKTC | YEGNGHFYRG | KASTDTMGRP | CLPWNSATVL | 
    150:
    QQTYHAHRSD | ALQLGLGKHN | YCRNPDNRRR | PWCYVQVGLK | PLVQECMVHD | 
    200:
    CADGKKPSSP | PEELKFQCGQ | KTLRPRFKII | GGEFTTIENQ | PWFAAIYRRH | 
    250:
    RGGSVTYVCG | GSLISPCWVI | SATHCFIDYP | KKEDYIVYLG | RSRLNSNTQG | 
    300:
    EMKFEVENLI | LHKDYSADTL | AHHNDIALLK | IRSKEGRCAQ | PSRTIQTICL | 
    350:
    PSMYNDPQFG | TSCEITGFGK | ENSTDYLYPE | QLKMTVVKLI | SHRECQQPHY | 
    400:
    YGSEVTTKML | CAADPQWKTD | SCQGDSGGPL | VCSLQGRMTL | TGIVSWGRGC | 
    431:
    ALKDKPGVYT | RVSHFLPWIR | SHTKEENGLA | L
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human U-plasminogen activator
    Cat.:
    E0140h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human U-plasminogen activator
    Cat.:
    E0140m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human U-plasminogen activator
    Cat.:
    E0140b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human U-plasminogen activator
    Cat.:
    E0140c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human U-plasminogen activator
    Cat.:
    E0140p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human U-plasminogen activator
    Cat.:
    E0140r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human U-plasminogen activator
    MSDS:
    Please sign in first.
    CLIA Kit for Human U-plasminogen activator
    MSDS:
    Please sign in first.
    CLIA Kit for Human U-plasminogen activator
    Cat.:
    U0140h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human U-plasminogen activator
    Cat.:
    U0140p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human U-plasminogen activator
    Cat.:
    U0140c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human U-plasminogen activator
    Cat.:
    U0140m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human U-plasminogen activator
    Cat.:
    U0140r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human U-plasminogen activator
    Cat.:
    U0140b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human U-plasminogen activator
    Cat.:
    P0140Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human U-plasminogen activator
    Cat.:
    P0140Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human U-plasminogen activator
    Cat.:
    P0140Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human U-plasminogen activator
    Polyclonal Antibody for Human U-plasminogen activator
    Polyclonal Antibody for Human U-plasminogen activator
    Polyclonal Antibody for Human U-plasminogen activator
    Monoclonal Antibody for Human U-plasminogen activator
    Monoclonal Antibody for Human U-plasminogen activator
    Monoclonal Antibody for Human U-plasminogen activator
    Monoclonal Antibody for Human U-plasminogen activator
    Monoclonal Antibody for Human U-plasminogen activator
    Monoclonal Antibody for Human U-plasminogen activator
    Monoclonal Antibody for Human U-plasminogen activator
    Protein for Human U-plasminogen activator
    Cat.:
    R0140h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human U-plasminogen activator
    Cat.:
    R0140m
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human U-plasminogen activator
    Protein for Human U-plasminogen activator
    Protein for Human U-plasminogen activator
    Protein for Human U-plasminogen activator
    Protein for Human U-plasminogen activator

    R&D Technical Data

    12% SDS-PAGE analysis

             12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and expression of the gene for pro-urokinase in Escherichia coli."
      Holmes W.E. , Pennica D. , Blaber M. , Rey M.W. , Guenzler W.A. , Steffens G.J. , Heyneker H.L.
      Biotechnology (N.Y.)3:923-929(1985)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Molecular cloning, sequencing, and expression in Escherichia coli of human preprourokinase cDNA."
      Jacobs P. , Cravador A. , Loriau R. , Brockly F. , Colau B. , Chuchana P. , van Elsen A. , Herzog A. , Bollen A.
      DNA4:139-146(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Molecular cloning of cDNA coding for human preprourokinase."
      Nagai M. , Hiramatsu R. , Kaneda T. , Hayasuke N. , Arimura H. , Nishida M. , Suyama T.
      Gene36:183-188(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "The human urokinase-plasminogen activator gene and its promoter."
      Riccio A. , Grimaldi G. , Verde P. , Sebastio G. , Boast S. , Blasi F.
      Nucleic Acids Res.13:2759-2771(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-214
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) System Donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Mesangial cell.
    7. 7.
      SeattleSNPs variation discovery resource
      Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-15; LEU-141 AND GLN-231
    8. 8.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-141
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    11. 11.
      "Characterization of single chain urokinase-type plasminogen activator with a novel amino-acid substitution in the kringle structure."
      Yoshimoto M. , Ushiyama Y. , Sakai M. , Tamaki S. , Hara H. , Takahashi K. , Sawasaki Y. , Hanada K.
      Biochim. Biophys. Acta1293:83-89(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-431;VARIANT LEU-141
    12. 12.
      "Characterization of a posttranslational fucosylation in the growth factor domain of urinary plasminogen activator."
      Buko A.M. , Kentzer E.J. , Petros A. , Menon G. , Zuiderweg E.R. , Sarin V.K.
      Proc. Natl. Acad. Sci. U.S.A.88:3992-3996(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-43;GLYCOSYLATION AT THR-38;IDENTIFICATION BY MASS SPECTROMETRY
    13. 13.
      "Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA."
      Verde P. , Stoppelli M.P. , Galeffi P. , di Nocera P. , Blasi F.
      Proc. Natl. Acad. Sci. U.S.A.81:4727-4731(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 66-431;VARIANT MET-214
    14. 14.
      "The primary structure of high molecular mass urokinase from human urine. The complete amino acid sequence of the A chain."
      Gunzler W.A. , Steffens G.J. , Otting F. , Kim S.-M.A. , Frankus E. , Flohe L.
      Hoppe-Seyler's Z. Physiol. Chem.363:1155-1165(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-177
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      "Human low-molecular-weight urinary urokinase. Partial characterization and preliminary sequence data of the two polypeptide chains."
      Schaller J. , Nick H. , Rickli E.E. , Gillessen D. , Lergier W. , Studer R.O.
      Eur. J. Biochem.125:251-257(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 156-176 AND 179-224
    16. 16.
      "The complete amino acid sequence of low molecular mass urokinase from human urine."
      Steffens G.J. , Gunzler W.A. , Otting F. , Frankus E. , Flohe L.
      Hoppe-Seyler's Z. Physiol. Chem.363:1043-1058(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 158-410
    17. 17.
      "Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for identity of PCI and plasminogen activator inhibitor 3."
      Stief T.W. , Radtke K.P. , Heimburger N.
      Biol. Chem. Hoppe-Seyler368:1427-1433(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;HETERODIMER WITH SERPINA5
    18. 18.
      "Phosphorylation of human pro-urokinase on Ser138/303 impairs its receptor-dependent ability to promote myelomonocytic adherence and motility."
      Franco P. , Iaccarino C. , Chiaradonna F. , Brandazza A. , Iavarone C. , Mastronicola M.R. , Nolli M.L. , Stoppelli M.P.
      J. Cell Biol.137:779-791(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-158 AND SER-323;MUTAGENESIS OF SER-158 AND SER-323
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      "Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility."
      He S. , Lin Y.L. , Liu Y.X.
      Mol. Hum. Reprod.5:513-519(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HETERODIMER WITH SERPINA5
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      "A urokinase receptor-associated protein with specific collagen binding properties."
      Behrendt N. , Jensen O.N. , Engelholm L.H. , Moertz E. , Mann M. , Danoe K.
      J. Biol. Chem.275:1993-2002(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MRC2
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      "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein."
      Liu C.-X. , Li Y. , Obermoeller-McCormick L.M. , Schwartz A.L. , Bu G.
      J. Biol. Chem.276:28889-28896(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP1B
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      "Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma."
      Wakita T. , Hayashi T. , Nishioka J. , Tamaru H. , Akita N. , Asanuma K. , Kamada H. , Gabazza E.C. , Ido M. , Kawamura J. , Suzuki K.
      Int. J. Cancer108:516-523(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;HETERODIMER WITH SERPINA5
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      "Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells."
      Ustach C.V. , Kim H.-R.C.
      Mol. Cell. Biol.25:6279-6288(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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      "Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene."
      Paterson A.D. , Rommens J.M. , Bharaj B. , Blavignac J. , Wong I. , Diamandis M. , Waye J.S. , Rivard G.E. , Hayward C.P.
      Blood115:1264-1266(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN QPD
    25. 25.
      "Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR."
      Oswald R.E. , Bogusky M.J. , Bamberger M. , Smith R.A.G. , Dobson C.M.
      Nature337:579-582(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
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      "Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase."
      Li X. , Smith R.A.G. , Dobson C.M.
      Biochemistry31:9562-9571(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 67-155
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      "Solution structure of the kringle domain from urokinase-type plasminogen activator."
      Li X. , Bokman A.M. , Llinas M. , Smith R.A.G. , Dobson C.M.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 67-155
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      "The crystal structure of the catalytic domain of human urokinase-type plasminogen activator."
      Spraggon G. , Phillips C. , Nowak U.K. , Ponting C.P. , Saunders D. , Dobson C.M. , Stuart D.I. , Jones E.Y.
      Structure3:681-691(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
    29. 29.
      "(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase."
      Sperl S. , Jacob U. , Arroyo de Prada N. , Sturzebecher J. , Wilhelm O.G. , Bode W. , Magdolen V. , Huber R. , Moroder L.
      Proc. Natl. Acad. Sci. U.S.A.97:5113-5118(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 159-411
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      "Structure of human urokinase plasminogen activator in complex with its receptor."
      Huai Q. , Mazar A.P. , Kuo A. , Parry G.C. , Shaw D.E. , Callahan J. , Li Y. , Yuan C. , Bian C. , Chen L. , Furie B. , Furie B.C. , Cines D.B. , Huang M.
      Science311:656-659(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 31-152 IN COMPLEX WITH PLAUR
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      "Detection of polymorphisms in the human urokinase-type plasminogen activator gene."
      Conne B. , Berczy M. , Belin D.
      Thromb. Haemost.77:434-435(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-141
    32. 32.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    33. 33.
      "Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer."
      Turkmen B. , Schmitt M. , Schmalfeldt B. , Trommler P. , Hell W. , Creutzburg S. , Graeff H. , Magdolen V.
      Electrophoresis18:686-689(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-141
    34. 34.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-141
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