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Index > Protein center > ENO2(Gene name) > Human
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  • ENO2 (Gene name),
  • Gamma-enolase (Protein name ),  ENOG_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (4)
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  • Gene name:
    ENO2;
    Protein name:
    Gamma-enolase;
    Alternative:
    Neuron-specific enolase(NSE);Neural enolase;2-phospho-D-glycerate hydro-lyase;Enolase 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific.
    Function:
    Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.
    Subcellular Location:
    Cytoplasm Cell membrane Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form.
    Protein Attributes:
    Sequence length:
    434
    Sequence:
    50:
    MSIEKIWARE | ILDSRGNPTV | EVDLYTAKGL | FRAAVPSGAS | TGIYEALELR | 
    100:
    DGDKQRYLGK | GVLKAVDHIN | STIAPALISS | GLSVVEQEKL | DNLMLELDGT | 
    150:
    ENKSKFGANA | ILGVSLAVCK | AGAAERELPL | YRHIAQLAGN | SDLILPVPAF | 
    200:
    NVINGGSHAG | NKLAMQEFMI | LPVGAESFRD | AMRLGAEVYH | TLKGVIKDKY | 
    250:
    GKDATNVGDE | GGFAPNILEN | SEALELVKEA | IDKAGYTEKI | VIGMDVAASE | 
    300:
    FYRDGKYDLD | FKSPTDPSRY | ITGDQLGALY | QDFVRDYPVV | SIEDPFDQDD | 
    350:
    WAAWSKFTAN | VGIQIVGDDL | TVTNPKRIER | AVEEKACNCL | LLKVNQIGSV | 
    400:
    TEAIQACKLA | QENGWGVMVS | HRSGETEDTF | IADLVVGLCT | GQIKTGAPCR | 
    434:
    SERLAKYNQL | MRIEEELGDE | ARFAGHNFRN | PSVL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    String:
    Pfam:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Gamma-enolase
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    E0537r
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    ELISA Kit for Human Gamma-enolase
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    E0537h
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    ELISA Kit for Human Gamma-enolase
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    E0537m
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    ELISA Kit for Human Gamma-enolase
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    E0537c
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    Packing:
    96T
    CLIA Kit for Human Gamma-enolase
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    U0537m
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    96T
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    CLIA Kit for Human Gamma-enolase
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    U0537c
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    Packing:
    96T
    CLIA Kit for Human Gamma-enolase
    Cat.:
    U0537h
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    Packing:
    96T
    CLIA Kit for Human Gamma-enolase
    Cat.:
    U0537r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Gamma-enolase
    Cat.:
    P0537Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Gamma-enolase
    Cat.:
    P0537Rb-r
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    40ug/0.2ml
    Polyclonal Antibody for Human Gamma-enolase
    Cat.:
    P0537Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Gamma-enolase
    Monoclonal Antibody for Human Gamma-enolase
    Monoclonal Antibody for Human Gamma-enolase
    Monoclonal Antibody for Human Gamma-enolase
    Monoclonal Antibody for Human Gamma-enolase
    Protein for Human Gamma-enolase
    Protein for Human Gamma-enolase
    Protein for Human Gamma-enolase
    Protein for Human Gamma-enolase

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    Linearity
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    References
    1. 1.
      "Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)."
      McAleese S.M. , Dunbar B. , Fothergill J. , Hinks L. , Day I.N.M.
      Eur. J. Biochem.178:413-417(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
      tissue: Retina.
    2. 2.
      "Human gamma enolase: isolation of a cDNA clone and expression in normal and tumor tissues of human origin."
      van Obberghen E. , Kamholz J. , Bishop J.G. III , Zomzely-Neurath C. , Lazzarini R.A.
      J. Neurosci. Res.19:450-456(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "Cloning, expression and sequence homologies of cDNA for human gamma enolase."
      Oliva D. , Barba G. , Barbieri G. , Giallongo A. , Feo S.
      Gene79:355-360(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Complete structure of the human gene encoding neuron-specific enolase."
      Oliva D. , Cali L. , Feo S. , Giallongo A.
      Genomics10:157-165(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Hematopoietic.
    5. 5.
      "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination."
      Ansari-Lari M.A. , Shen Y. , Muzny D.M. , Lee W. , Gibbs R.A.
      Genome Res.7:268-280(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Brain.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Caudate nucleus.
    7. 7.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    10. 10.
      Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 16-28; 33-50; 90-103; 163-179; 184-193; 240-262; 270-285; 336-372 AND 413-422;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    11. 11.
      "Sequence conservation in the 3'-untranslated regions of neurone-specific enolase, lymphokine and protooncogene mRNAs."
      Day I.N.M. , Allsopp M.T.E.P. , Moore D.C.M. , Thompson R.J.
      FEBS Lett.222:139-143(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 425-434 (ISOFORM 1/2)
    12. 12.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-44;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-26;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Expression, purification and the 1.8 angstroms resolution crystal structure of human neuron specific enolase."
      Chai G. , Brewer J.M. , Lovelace L.L. , Aoki T. , Minor W. , Lebioda L.
      J. Mol. Biol.341:1015-1021(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH MAGNESIUM IONS
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