Gene name:
HSP90B1 (GRP94;TRA1) ;
Protein name:
Endoplasmin ;
Alternative:
Heat shock protein 90 kDa beta member 1 ;94 kDa glucose-regulated protein (GRP-94) ;gp96 homolog ;Tumor rejection antigen 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9.
Function:
Molecular chaperone that functions in the processing and transport of secreted proteins. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
Subcellular Location:
Endoplasmic reticulum lumen
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Attributes:
50:
MRALWVLGLC | CVLLTFGSVR | ADDEVDVDGT | VEEDLGKSRE | GSRTDDEVVQ |
100:
REEEAIQLDG | LNASQIRELR | EKSEKFAFQA | EVNRMMKLII | NSLYKNKEIF |
150:
LRELISNASD | ALDKIRLISL | TDENALSGNE | ELTVKIKCDK | EKNLLHVTDT |
200:
GVGMTREELV | KNLGTIAKSG | TSEFLNKMTE | AQEDGQSTSE | LIGQFGVGFY |
250:
SAFLVADKVI | VTSKHNNDTQ | HIWESDSNEF | SVIADPRGNT | LGRGTTITLV |
300:
LKEEASDYLE | LDTIKNLVKK | YSQFINFPIY | VWSSKTETVE | EPMEEEEAAK |
350:
EEKEESDDEA | AVEEEEEEKK | PKTKKVEKTV | WDWELMNDIK | PIWQRPSKEV |
400:
EEDEYKAFYK | SFSKESDDPM | AYIHFTAEGE | VTFKSILFVP | TSAPRGLFDE |
450:
YGSKKSDYIK | LYVRRVFITD | DFHDMMPKYL | NFVKGVVDSD | DLPLNVSRET |
500:
LQQHKLLKVI | RKKLVRKTLD | MIKKIADDKY | NDTFWKEFGT | NIKLGVIEDH |
550:
SNRTRLAKLL | RFQSSHHPTD | ITSLDQYVER | MKEKQDKIYF | MAGSSRKEAE |
600:
SSPFVERLLK | KGYEVIYLTE | PVDEYCIQAL | PEFDGKRFQN | VAKEGVKFDE |
650:
SEKTKESREA | VEKEFEPLLN | WMKDKALKDK | IEKAVVSQRL | TESPCALVAS |
700:
QYGWSGNMER | IMKAQAYQTG | KDISTNYYAS | QKKTFEINPR | HPLIRDMLRR |
750:
IKEDEDDKTV | LDLAVVLFET | ATLRSGYLLP | DTKAYGDRIE | RMLRLSLNID |
800:
PDAKVEEEPE | EEPEETAEDT | TEDTEQDEDE | EMDVGTDEEE | ETAKESTAEK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rabbit
Dog
Chicken
Pig
Bovine
Rat
ELISA Kit for Human Endoplasmin
ELISA Kit for Human Endoplasmin
ELISA Kit for Human Endoplasmin
ELISA Kit for Human Endoplasmin
ELISA Kit for Human Endoplasmin
ELISA Kit for Human Endoplasmin
ELISA Kit for Human Endoplasmin
ELISA Kit for Human Endoplasmin
CLIA Kit for Human Endoplasmin
CLIA Kit for Human Endoplasmin
CLIA Kit for Human Endoplasmin
CLIA Kit for Human Endoplasmin
CLIA Kit for Human Endoplasmin
CLIA Kit for Human Endoplasmin
CLIA Kit for Human Endoplasmin
CLIA Kit for Human Endoplasmin
Polyclonal Antibody for Human Endoplasmin
Polyclonal Antibody for Human Endoplasmin
Polyclonal Antibody for Human Endoplasmin
Polyclonal Antibody for Human Endoplasmin
Polyclonal Antibody for Human Endoplasmin
Polyclonal Antibody for Human Endoplasmin
Polyclonal Antibody for Human Endoplasmin
Polyclonal Antibody for Human Endoplasmin
Monoclonal Antibody for Human Endoplasmin
Monoclonal Antibody for Human Endoplasmin
Monoclonal Antibody for Human Endoplasmin
Monoclonal Antibody for Human Endoplasmin
Monoclonal Antibody for Human Endoplasmin
Monoclonal Antibody for Human Endoplasmin
Monoclonal Antibody for Human Endoplasmin
Monoclonal Antibody for Human Endoplasmin
Protein for Human Endoplasmin
Protein for Human Endoplasmin
Protein for Human Endoplasmin
Protein for Human Endoplasmin
Protein for Human Endoplasmin
Protein for Human Endoplasmin
Protein for Human Endoplasmin
Protein for Human Endoplasmin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16
tissue :
Blood .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Skin .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16
tissue :
Liver .
4.
"The association of heat shock protein gp96 with HBV-derived peptides in vitro."
Meng S.
,
Tien P.
Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 22-803
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 22-39
tissue :
Platelet .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : COMPONENT OF A CHAPERONE COMPLEX
7.
"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
Basrur V.
,
Yang F.
,
Kushimoto T.
,
Higashimoto Y.
,
Yasumoto K.
,
Valencia J.
,
Muller J.
,
Vieira W.D.
,
Watabe H.
,
Shabanowitz J.
,
Hearing V.J.
,
Hunt D.F.
,
Appella E.
J. Proteome Res.2:69-79(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Melanoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-217 AND ASN-445
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
10.
"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
Liu B.
,
Yang Y.
,
Qiu Z.
,
Staron M.
,
Hong F.
,
Li Y.
,
Wu S.
,
Li Y.
,
Hao B.
,
Bona R.
,
Han D.
,
Li Z.
Nat. Commun.1:79-79(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CNPY3; TLR4 AND TLR9
11.
Liu B.
,
Yang Y.
,
Qiu Z.
,
Staron M.
,
Hong F.
,
Li Y.
,
Wu S.
,
Li Y.
,
Hao B.
,
Bona R.
,
Han D.
,
Li Z.
Nat. Commun.3:653-653(2012)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
12.
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A.
,
Valencia J.C.
,
Hu Z.-Z.
,
Watabe H.
,
Yamaguchi H.
,
Mangini N.J.
,
Huang H.
,
Canfield V.A.
,
Cheng K.C.
,
Yang F.
,
Abe R.
,
Yamagishi S.
,
Shabanowitz J.
,
Hearing V.J.
,
Wu C.
,
Appella E.
,
Hunt D.F.
J. Proteome Res.5:3135-3144(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Melanoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-107
tissue :
Platelet .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH OS9
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-62; ASN-107; ASN-217 AND ASN-445
tissue :
Liver .
16.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH METTL23