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Index > Protein center > EPCAM(Gene name) > Human
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  • EPCAM (Gene name),
  • Epithelial cell adhesion molecule (Protein name ),  EPCAM_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    EPCAM(GA733-2;M1S2;M4S1;MIC18;TACSTD1;TROP1);
    Protein name:
    Epithelial cell adhesion molecule(Ep-CAM);
    Alternative:
    Cell surface glycoprotein Trop-1;Adenocarcinoma-associated antigen;Epithelial glycoprotein(EGP);Epithelial cell surface antigen;KS 1/4 antigen;Epithelial glycoprotein 314(EGP314;hEGP314);Major gastrointestinal tumor-associated protein GA733-2;KSA;Tumor-associated calcium signal transducer 1;
    CD:
    CD326;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Interacts with phosphorylated CLDN7.
    Function:
    May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
    Subcellular Location:
    Lateral cell membrane Single-pass type I membrane protein Cell junction tight junction Co-localizes with CLDN7 at the lateral cell membrane and tight junction.
    Protein Attributes:
    Sequence length:
    314
    Sequence:
    50:
    MAPPQVLAFG | LLLAAATATF | AAAQEECVCE | NYKLAVNCFV | NNNRQCQCTS | 
    100:
    VGAQNTVICS | KLAAKCLVMK | AEMNGSKLGR | RAKPEGALQN | NDGLYDPDCD | 
    150:
    ESGLFKAKQC | NGTSMCWCVN | TAGVRRTDKD | TEITCSERVR | TYWIIIELKH | 
    200:
    KAREKPYDSK | SLRTALQKEI | TTRYQLDPKF | ITSILYENNV | ITIDLVQNSS | 
    250:
    QKTQNDVDIA | DVAYYFEKDV | KGESLFHSKK | MDLTVNGEQL | DLDPGQTLIY | 
    300:
    YVDEKAPEFS | MQGLKAGVIA | VIVVVVIAVV | AGIVVLVISR | KKRMAKYEKA | 
    314:
    EIKEMGEMHR | ELNA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    MIM:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ep-CAM
    Cat.:
    E1283h
    Price:
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    Packing:
    96T
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    ELISA Kit for Human Ep-CAM
    Cat.:
    E1283m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Ep-CAM
    Cat.:
    E1283r
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    96T
    ELISA Kit for Human Ep-CAM
    Cat.:
    E1283b
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    96T
    ELISA Kit for Human Ep-CAM
    Cat.:
    E1283c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ep-CAM
    Cat.:
    U1283b
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    96T
    CLIA Kit for Human Ep-CAM
    Cat.:
    U1283c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ep-CAM
    Cat.:
    U1283r
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    MSDS:
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    Packing:
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    CLIA Kit for Human Ep-CAM
    Cat.:
    U1283h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Ep-CAM
    Cat.:
    U1283m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Ep-CAM
    Polyclonal Antibody for Human Ep-CAM
    Cat.:
    P1283Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ep-CAM
    Cat.:
    P1283Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ep-CAM
    Polyclonal Antibody for Human Ep-CAM
    Cat.:
    P1283Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ep-CAM
    Monoclonal Antibody for Human Ep-CAM
    Monoclonal Antibody for Human Ep-CAM
    Monoclonal Antibody for Human Ep-CAM
    Monoclonal Antibody for Human Ep-CAM
    Protein for Human Ep-CAM
    Protein for Human Ep-CAM
    Protein for Human Ep-CAM
    Protein for Human Ep-CAM
    Protein for Human Ep-CAM

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    References
    1. 1.
      "Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA."
      Strnad J. , Hamilton A.E. , Beavers L.S. , Gamboa G.C. , Apelgren L.D. , Taber L.D. , Sportsman J.R. , Bumol T.F. , Sharp J.D. , Gadski R.A.
      Cancer Res.49:314-317(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-115
      tissue: Lung adenocarcinoma.
    2. 2.
      "Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker."
      Perez M.S. , Walker L.E.
      J. Immunol.142:3662-3667(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-115
    3. 3.
      "Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein."
      Simon B. , Podolsky D.K. , Moldenhauer G. , Isselbacher K.J. , Gattoni-Celli S. , Brand S.J.
      Proc. Natl. Acad. Sci. U.S.A.87:2755-2759(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-115
    4. 4.
      "Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2."
      Szala S. , Froehlich M. , Scollon M. , Kasai Y. , Steplewski Z. , Koprowski H. , Linnenbach A.J.
      Proc. Natl. Acad. Sci. U.S.A.87:3542-3546(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Colon carcinoma.
    5. 5.
      "Retroposition in a family of carcinoma-associated antigen genes."
      Linnenbach A.J. , Seng B.A. , Wu S. , Robbins S. , Scollon M. , Pyrc J.J. , Druck T. , Huebner K.
      Mol. Cell. Biol.13:1507-1515(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Lymphoma.
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-115
      tissue: Ovary.
    10. 10.
      "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733."
      Linnenbach A.J. , Wojcierowski J. , Wu S. , Pyrc J.J. , Ross A.H. , Dietzschold B. , Speicher D. , Koprowski H.
      Proc. Natl. Acad. Sci. U.S.A.86:27-31(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-126
      tissue: Placenta.
    11. 11.
      "Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody."
      Bjoerk P. , Joensson U. , Svedberg H. , Larsson K. , Lind P. , Dillner J. , Hedlund G. , Dohlsten M. , Kalland T.
      J. Biol. Chem.268:24232-24241(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 82-100;SUBUNIT
    12. 12.
      "Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)."
      Chong J.M. , Speicher D.W.
      J. Biol. Chem.276:5804-5813(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;GLYCOSYLATION AT ASN-74 AND ASN-111
    13. 13.
      "The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation."
      Muenz M. , Kieu C. , Mack B. , Schmitt B. , Zeidler R. , Gires O.
      Oncogene23:5748-5758(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    14. 14.
      "The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP."
      Muenz M. , Zeidler R. , Gires O.
      Cancer Lett.225:151-157(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      "The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7."
      Ladwein M. , Pape U.F. , Schmidt D.S. , Schnoelzer M. , Fiedler S. , Langbein L. , Franke W.W. , Moldenhauer G. , Zoeller M.
      Exp. Cell Res.309:345-357(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH CLDN7
    16. 16.
      "Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM."
      Munz M. , Fellinger K. , Hofmann T. , Schmitt B. , Gires O.
      Front. Biosci.13:5195-5201(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-74; ASN-111 AND ASN-198;MUTAGENESIS OF ASN-74; ASN-111 AND ASN-198
    17. 17.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198
      tissue: Liver.
    18. 18.
      "Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1."
      Ligtenberg M.J. , Kuiper R.P. , Chan T.L. , Goossens M. , Hebeda K.M. , Voorendt M. , Lee T.Y. , Bodmer D. , Hoenselaar E. , Hendriks-Cornelissen S.J. , Tsui W.Y. , Kong C.K. , Brunner H.G. , van Kessel A.G. , Yuen S.T. , van Krieken J.H. , Leung S.Y. , Hoogerbrugge N.
      Nat. Genet.41:112-117(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HNPCC8
    19. 19.
      "Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells."
      Lu T.Y. , Lu R.M. , Liao M.Y. , Yu J. , Chung C.H. , Kao C.F. , Wu H.C.
      J. Biol. Chem.285:8719-8732(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    20. 20.
      "Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells."
      Ng V.Y. , Ang S.N. , Chan J.X. , Choo A.B.
      Stem Cells28:29-35(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DIAR5 TYR-66
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