EPHA3 ELISA Kit for Human(Homo sapiens) | EIAab.comEPHA3 ELISA Kit for Human(Homo sapiens)

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EPHA3 (Gene name),

Ephrin type-A receptor 3 (Protein name ), EPHA3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

EPHA3(ETK;ETK1;HEK;TYRO4);

Protein name:

Ephrin type-A receptor 3;

Alternative:

HEK(Human embryo kinase);EPH-like kinase 4(EK4;hEK4);Tyrosine-protein kinase receptor ETK1(Eph-like tyrosine kinase 1);Tyrosine-protein kinase TYRO4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation.

Function:

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

Subcellular Location:

Isoform 2 Secreted

Protein Attributes:

Sequence length:

983

Sequence:

50:

100:

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300:

350:

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750:

800:

850:

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950:

983:

MKKVGVTVVG | PQKKIISSIK | ALETQSKNGP | VPV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P29320

STRING:

9606.ENSP00000337451

UniGene:

Hs.123642

Pfam:

PF01404

String:

P29320

KEGG:

hsa:2042

Pfam:

PF14575

MIM:

114500

Uniprot:

P29320

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ELISA Kit for Human Ephrin type-A receptor 3

Cat.:

E1114c

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Packing:

96T

ELISA Kit for Human Ephrin type-A receptor 3

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E1114r

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96T

ELISA Kit for Human Ephrin type-A receptor 3

Cat.:

E1114h

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96T

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ELISA Kit for Human Ephrin type-A receptor 3

Cat.:

E1114m

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96T

CLIA Kit for Human Ephrin type-A receptor 3

Cat.:

U1114h

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96T

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CLIA Kit for Human Ephrin type-A receptor 3

Cat.:

U1114c

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96T

CLIA Kit for Human Ephrin type-A receptor 3

Cat.:

U1114r

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MSDS:

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96T

CLIA Kit for Human Ephrin type-A receptor 3

Cat.:

U1114m

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96T

Polyclonal Antibody for Human Ephrin type-A receptor 3

Cat.:

P1114Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Ephrin type-A receptor 3

Cat.:

P1114Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Ephrin type-A receptor 3

Cat.:

P1114Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Ephrin type-A receptor 3

Protein for Human Ephrin type-A receptor 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines."
Wicks I.P. , Wilkinson D. , Salvaris E. , Boyd A.W.
Proc. Natl. Acad. Sci. U.S.A.89:1611-1615(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-924
2.

"Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules."
Chiari R. , Hames G. , Stroobant V. , Texier C. , Maillere B. , Boon T. , Coulie P.G.
Cancer Res.60:4855-4863(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Melanoma.
3.

"Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line."
Boyd A.W. , Ward L.D. , Wicks I.P. , Simpson R.J. , Salvaris E. , Wilks A. , Welch K. , Loudovaris M. , Rockman S. , Busmanis I.
J. Biol. Chem.267:3262-3267(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-29 AND 840-860;CHARACTERIZATION
4.

"Unified nomenclature for Eph family receptors and their ligands, the ephrins."
Eph nomenclature committee
Cell90:403-404(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NOMENCLATURE
5.

"Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling."
Lawrenson I.D. , Wimmer-Kleikamp S.H. , Lock P. , Schoenwaelder S.M. , Down M. , Boyd A.W. , Alewood P.F. , Lackmann M.
J. Cell Sci.115:1059-1072(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL-CELL ADHESION;EFNA5-BINDING;SUBCELLULAR LOCATION;INTERACTION WITH CRK;PHOSPHORYLATION AT TYR-596; TYR-602 AND TYR-779
6.

"Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen."
Smith F.M. , Vearing C. , Lackmann M. , Treutlein H. , Himanen J. , Chen K. , Saul A. , Nikolov D. , Boyd A.W.
J. Biol. Chem.279:9522-9531(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EPHRIN LIGAND-BINDING;OLIGOMERIZATION;MUTAGENESIS OF VAL-133 AND PHE-152;INTERACTION WITH CRK
7.

"Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans."
Janes P.W. , Saha N. , Barton W.A. , Kolev M.V. , Wimmer-Kleikamp S.H. , Nievergall E. , Blobel C.P. , Himanen J.P. , Lackmann M. , Nikolov D.B.
Cell123:291-304(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH ADAM10 AND EFNA5
8.

"Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3."
Day B. , To C. , Himanen J.P. , Smith F.M. , Nikolov D.B. , Boyd A.W. , Lackmann M.
J. Biol. Chem.280:26526-26532(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EFNA5 LIGAND-BINDING
9.

"PTP1B regulates Eph receptor function and trafficking."
Nievergall E. , Janes P.W. , Stegmayer C. , Vail M.E. , Haj F.G. , Teng S.W. , Neel B.G. , Bastiaens P.I. , Lackmann M.
J. Cell Biol.191:1189-1203(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN1;PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN1;SUBCELLULAR LOCATION
10.

"Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3)."
Davis T.L. , Walker J.R. , Loppnau P. , Butler-Cole C. , Allali-Hassani A. , Dhe-Paganon S.
Structure16:873-884(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.07 ANGSTROMS) OF 577-947 IN COMPLEX WITH ATP ANALOG;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT TYR-596; TYR-602 AND TYR-701;MUTAGENESIS OF TYR-596; TYR-602; TYR-742 AND SER-768
11.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-37; SER-85; LEU-621 AND ASN-806
12.

"Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers."
Wood L.D. , Calhoun E.S. , Silliman N. , Ptak J. , Szabo S. , Powell S.M. , Riggins G.J. , Wang T.L. , Yan H. , Gazdar A. , Kern S.E. , Pennacchio L. , Kinzler K.W. , Vogelstein B. , Velculescu V.E.
Hum. Mutat.27:1060-1061(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-660 AND MET-933
13.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] TYR-229; PHE-449; LEU-518; VAL-564; SER-568; PRO-590; GLU-766; GLY-777; HIS-914 AND ARG-924
14.

"Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas."
Corbo V. , Ritelli R. , Barbi S. , Funel N. , Campani D. , Bardelli A. , Scarpa A.
PLoS ONE5:E12653-E12653(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-207

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