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Index > Protein center > ERCC1(Gene name) > Human
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  • ERCC1 (Gene name),
  • DNA excision repair protein ERCC-1 (Protein name ),  ERCC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    ERCC1;
    Protein name:
    DNA excision repair protein ERCC-1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer composed of ERCC1 and XPF/ERRC4.
    Function:
    Structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    297
    Sequence:
    50:
    MDPGKDKEGV | PQPSGPPARK | KFVIPLDEDE | VPPGVAKPLF | RSTQSLPTVD | 
    100:
    TSAQAAPQTY | AEYAISQPLE | GAGATCPTGS | EPLAGETPNQ | ALKPGAKSNS | 
    150:
    IIVSPRQRGN | PVLKFVRNVP | WEFGDVIPDY | VLGQSTCALF | LSLRYHNLHP | 
    200:
    DYIHGRLQSL | GKNFALRVLL | VQVDVKDPQQ | ALKELAKMCI | LADCTLILAW | 
    250:
    SPEEAGRYLE | TYKAYEQKPA | DLLMEKLEQD | FVSRVTECLT | TVKSVNKTDS | 
    297:
    QTLLTTFGSL | EQLIAASRED | LALCPGLGPQ | KARRLFDVLH | EPFLKVP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    Pfam:
    SMR:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human DNA excision repair protein ERCC-1
    Cat.:
    E1871h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human DNA excision repair protein ERCC-1
    Cat.:
    E1871b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human DNA excision repair protein ERCC-1
    Cat.:
    E1871m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA excision repair protein ERCC-1
    Cat.:
    U1871h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA excision repair protein ERCC-1
    Cat.:
    U1871m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA excision repair protein ERCC-1
    Cat.:
    U1871b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human DNA excision repair protein ERCC-1
    Polyclonal Antibody for Human DNA excision repair protein ERCC-1
    Cat.:
    P1871Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DNA excision repair protein ERCC-1
    Cat.:
    P1871Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human DNA excision repair protein ERCC-1
    Monoclonal Antibody for Human DNA excision repair protein ERCC-1
    Monoclonal Antibody for Human DNA excision repair protein ERCC-1
    Protein for Human DNA excision repair protein ERCC-1
    Protein for Human DNA excision repair protein ERCC-1
    Protein for Human DNA excision repair protein ERCC-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10."
      van Duin M. , de Wit J. , Odijk H. , Westerveld A. , Yasui A. , Koken M.H.M. , Hoeijmakers J.H.J. , Bootsma D.
      Cell44:913-923(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "A nucleotide polymorphism in ERCC1 in human ovarian cancer cell lines and tumor tissues."
      Yu J.J. , Mu C.J. , Lee K.B. , Okamoto A. , Reed E.L. , Bostick-Bruton F. , Mitchell K.C. , Reed E.
      Mutat. Res.382:13-20(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Human excision repair protein 1, transcript variant, mRNA."
      Hisatomi H. , Nagao K. , Ishikawa H. , Yokoyama Y. , Ishihara Y. , Hikiji K. , Iizuka T.
      Submitted (2001-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      NIEHS SNPs program
      Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-266
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
      tissue: Cerebellum.
    7. 7.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Lung.
      tissue: Uterus.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform."
      Friboulet L. , Postel-Vinay S. , Sourisseau T. , Adam J. , Stoclin A. , Ponsonnailles F. , Dorvault N. , Commo F. , Saulnier P. , Salome-Desmoulez S. , Pottier G. , Andre F. , Kroemer G. , Soria J.C. , Olaussen K.A.
      Cell Cycle12:3298-3306(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 1);SUBCELLULAR LOCATION;SUBUNIT
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
    14. 14.
      "Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1."
      Tsodikov O.V. , Enzlin J.H. , Scharer O.D. , Ellenberger T.
      Proc. Natl. Acad. Sci. U.S.A.102:11236-11241(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 96-227;X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 96-220-296 IN COMPLEX WIRH ERCC4;SUBUNIT
    15. 15.
      "The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair."
      Tripsianes K. , Folkers G. , Ab E. , Das D. , Odijk H. , Jaspers N.G. , Hoeijmakers J.H. , Kaptein R. , Boelens R.
      Structure13:1849-1858(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 220-297 IN COMPLEX WIRH ERCC4;SUBUNIT
    16. 16.
      "First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure."
      Jaspers N.G.J. , Raams A. , Silengo M.C. , Wijgers N. , Niedernhofer L.J. , Robinson A.R. , Giglia-Mari G. , Hoogstraten D. , Kleijer W.J. , Hoeijmakers J.H.J. , Vermeulen W.
      Am. J. Hum. Genet.80:457-466(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT COFS4 LEU-231
    17. 17.
      "Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia."
      Kashiyama K. , Nakazawa Y. , Pilz D.T. , Guo C. , Shimada M. , Sasaki K. , Fawcett H. , Wing J.F. , Lewin S.O. , Carr L. , Li T.S. , Yoshiura K. , Utani A. , Hirano A. , Yamashita S. , Greenblatt D. , Nardo T. , Stefanini M. , more...
      Am. J. Hum. Genet.92:807-819(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT COFS4 LEU-231;CHARACTERIZATION OF VARIANT COFS4 LEU-231
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