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Index > Protein center > ESR1(Gene name) > Human
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  • ESR1 (Gene name),
  • Estrogen receptor (Protein name ),  ESR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    ESR1(ESR;NR3A1);
    Protein name:
    Estrogen receptor(ER);
    Alternative:
    Estradiol receptor;ER-alpha;Nuclear receptor subfamily 3 group A member 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with FOXC2, MAP1S, SLC30A9, UBE1C and NCOA3 coactivator (By similarity). Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent. Interacts with NCOA5 and NCOA6 coactivators. Interacts with NCOA7; the interaction is a ligand-inducible. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via C-terminus). Interacts with MACROD1. Interacts with SH2D4A and PLCG. Interaction with SH2D4A blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with DYX1C1. Interacts with PRMT2. Interacts with PI3KR1 or PI3KR2, SRC and PTK2. Interacts with RBFOX2. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa.
    Function:
    Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
    Subcellular Location:
    Isoform 3 Nucleus Cytoplasm Cell membrane Peripheral membrane protein Cytoplasmic side Associated with the inner membrane via palmitoylation.
    Protein Attributes:
    Sequence length:
    595
    Sequence:
    50:
    MTMTLHTKAS | GMALLHQIQG | NELEPLNRPQ | LKIPLERPLG | EVYLDSSKPA | 
    100:
    VYNYPEGAAY | EFNAAAAANA | QVYGQTGLPY | GPGSEAAAFG | SNGLGGFPPL | 
    150:
    NSVSPSPLML | LHPPPQLSPF | LQPHGQQVPY | YLENEPSGYT | VREAGPPAFY | 
    200:
    RPNSDNRRQG | GRERLASTND | KGSMAMESAK | ETRYCAVCND | YASGYHYGVW | 
    250:
    SCEGCKAFFK | RSIQGHNDYM | CPATNQCTID | KNRRKSCQAC | RLRKCYEVGM | 
    300:
    MKGGIRKDRR | GGRMLKHKRQ | RDDGEGRGEV | GSAGDMRAAN | LWPSPLMIKR | 
    350:
    SKKNSLALSL | TADQMVSALL | DAEPPILYSE | YDPTRPFSEA | SMMGLLTNLA | 
    400:
    DRELVHMINW | AKRVPGFVDL | TLHDQVHLLE | CAWLEILMIG | LVWRSMEHPG | 
    450:
    KLLFAPNLLL | DRNQGKCVEG | MVEIFDMLLA | TSSRFRMMNL | QGEEFVCLKS | 
    500:
    IILLNSGVYT | FLSSTLKSLE | EKDHIHRVLD | KITDTLIHLM | AKAGLTLQQQ | 
    550:
    HQRLAQLLLI | LSHIRHMSNK | GMEHLYSMKC | KNVVPLYDLL | LEMLDAHRLH | 
    595:
    APTSRGGASV | EETDQSHLAT | AGSTSSHSLQ | KYYITGEAEG | FPATV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    Pfam:
    SMR:
    MIM:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human ER
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    E1050h
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    Packing:
    96T
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    ELISA Kit for Human ER
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    E1050r
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    MSDS:
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    96T
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    ELISA Kit for Human ER
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    E1050m
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    96T
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    ELISA Kit for Human ER
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    E1050c
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    ELISA Kit for Human ER
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    E1050p
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    ELISA Kit for Human ER
    Cat.:
    E1050b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ER
    Cat.:
    U1050c
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human ER
    Cat.:
    U1050m
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ER
    Cat.:
    U1050r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ER
    Cat.:
    U1050h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human ER
    Cat.:
    U1050b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ER
    Cat.:
    U1050p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ER
    Polyclonal Antibody for Human ER
    Polyclonal Antibody for Human ER
    Cat.:
    P1050Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ER
    Cat.:
    P1050Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ER
    Polyclonal Antibody for Human ER
    Cat.:
    P1050Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ER
    Monoclonal Antibody for Human ER
    Monoclonal Antibody for Human ER
    Monoclonal Antibody for Human ER
    Monoclonal Antibody for Human ER
    Monoclonal Antibody for Human ER
    Protein for Human ER
    Protein for Human ER
    Protein for Human ER
    Protein for Human ER
    Protein for Human ER
    Protein for Human ER

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    Linearity
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    References
    1. 1.
      "Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A."
      Green S. , Walter P. , Kumar V. , Krust A. , Bornert J.-M. , Argos P. , Chambon P.
      Nature320:134-139(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Sequence and expression of human estrogen receptor complementary DNA."
      Greene G.L. , Gilna P. , Waterfield M. , Baker A. , Hort Y. , Shine J.
      Science231:1150-1154(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "A novel 80 kDa human estrogen receptor containing a duplication of exons 6 and 7."
      Pink J.J. , Wu S.Q. , Wolf D.M. , Bilimoria M.M. , Jordan V.C.
      Nucleic Acids Res.24:962-969(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Mammary gland.
    4. 4.
      NIEHS SNPs program
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-77
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
    6. 6.
      "Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66."
      Wang Z. , Zhang X. , Shen P. , Loggie B.W. , Chang Y. , Deuel T.F.
      Biochem. Biophys. Res. Commun.336:1023-1027(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);ALTERNATIVE PROMOTER USAGE;SUBCELLULAR LOCATION
      tissue: Placenta.
    7. 7.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    10. 10.
      "Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor."
      Joel P.B. , Traish A.M. , Lannigan D.A.
      Mol. Endocrinol.9:1041-1052(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 110-117;PHOSPHORYLATION;MUTAGENESIS
    11. 11.
      "Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene and breast cancer susceptibility."
      Schubert E.L. , Lee M.K. , Newman B. , King M.C.
      J. Steroid Biochem. Mol. Biol.71:21-27(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-595 (ISOFORM 1)
    12. 12.
      "Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer cell lines."
      Pfeffer U. , Fecarotta E. , Castagnetta L. , Vidali G.
      Cancer Res.53:741-743(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-434;ALTERNATIVE SPLICING
      tissue: Mammary carcinoma.
    13. 13.
      "Mechanisms of acquired tamoxifen resistance in a xenotransplanted human breast carcinoma."
      Naundorf H. , Becker M. , Fiebig C. , Buettner B. , Fichtner I.
      Submitted (1996-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 354-548
      tissue: Mammary carcinoma.
    14. 14.
      "Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro."
      Arnold S.F. , Obourn J.D. , Jaffe H. , Notides A.C.
      Mol. Endocrinol.9:24-33(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 532-542;PHOSPHORYLATION AT TYR-537
    15. 15.
      "Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation."
      Reese J.C. , Katzenellenbogen B.S.
      J. Biol. Chem.267:9868-9873(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-447
    16. 16.
      "Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor."
      Arnold S.F. , Obourn J.D. , Jaffe H. , Notides A.C.
      Mol. Endocrinol.8:1208-1214(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-167 BY CK2
    17. 17.
      "Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta."
      Stein B. , Yang M.X.
      Mol. Cell. Biol.15:4971-4979(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSREPRESSION OF NF-KAPPA-B
    18. 18.
      "Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha."
      Endoh H. , Maruyama K. , Masuhiro Y. , Kobayashi Y. , Goto M. , Tai H. , Yanagisawa J. , Metzger D. , Hashimoto S. , Kato S.
      Mol. Cell. Biol.19:5363-5372(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDX5;MUTAGENESIS OF SER-118
    19. 19.
      "Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1."
      Flouriot G. , Brand H. , Denger S. , Metivier R. , Kos M. , Reid G. , Sonntag-Buck V. , Gannon F.
      EMBO J.19:4688-4700(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 3);TISSUE SPECIFICITY;ALTERNATIVE PROMOTER USAGE (ISOFORM 3);SUBUNIT
    20. 20.
      "Function of N-terminal transactivation domain of the estrogen receptor requires a potential alpha-helical structure and is negatively regulated by the A domain."
      Metivier R. , Petit F.G. , Valotaire Y. , Pakdel F.
      Mol. Endocrinol.14:1849-1871(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-39 AND TYR-43
    21. 21.
      "Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells."
      Bai Y. , Giguere V.
      Mol. Endocrinol.17:589-599(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA1; NCOA2 AND NCOA3;SUBUNIT;MUTAGENESIS OF LEU-539
    22. 22.
      "Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells."
      Li L. , Haynes M.P. , Bender J.R.
      Proc. Natl. Acad. Sci. U.S.A.100:4807-4812(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION (ISOFORMS 1 AND 3);PALMITOYLATION (ISOFORM 3)
    23. 23.
      "A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine."
      Jiang M.S. , Hart G.W.
      J. Biol. Chem.272:2421-2428(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
    24. 24.
      "Functional synergy between the transcription factor Sp1 and the estrogen receptor."
      Porter W. , Saville B. , Hoivik D. , Safe S.
      Mol. Endocrinol.11:1569-1580(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SP1
    25. 25.
      "Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action."
      Rubino D. , Driggers P. , Arbit D. , Kemp L. , Miller B. , Coso O. , Pagliai K. , Gray K. , Gutkind S. , Segars J.
      Oncogene16:2513-2526(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKAP13
    26. 26.
      "Potentiation of human estrogen receptor alpha transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex."
      Rogatsky I. , Trowbridge J.M. , Garabedian M.J.
      J. Biol. Chem.274:22296-22302(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-104 AND SER-106;MUTAGENESIS
    27. 27.
      "A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."
      Lee S.-K. , Anzick S.L. , Choi J.-E. , Bubendorf L. , Guan X.-Y. , Jung Y.-K. , Kallioniemi O.-P. , Kononen J. , Trent J.M. , Azorsa D. , Jhun B.-H. , Cheong J.H. , Lee Y.C. , Meltzer P.S. , Lee J.W.
      J. Biol. Chem.274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
    28. 28.
      "An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens."
      Montano M.M. , Ekena K. , Delage-Mourroux R. , Chang W. , Martini P. , Katzenellenbogen B.S.
      Proc. Natl. Acad. Sci. U.S.A.96:6947-6952(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PHB2
    29. 29.
      "Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2."
      Benecke A. , Chambon P. , Gronemeyer H.
      EMBO Rep.1:151-157(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA2
    30. 30.
      "Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements."
      Saville B. , Wormke M. , Wang F. , Nguyen T. , Enmark E. , Kuiper G. , Gustafsson J.A. , Safe S.
      J. Biol. Chem.275:5379-5387(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SP1
    31. 31.
      "Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins."
      Stoner M. , Wang F. , Wormke M. , Nguyen T. , Samudio I. , Vyhlidal C. , Marme D. , Finkenzeller G. , Safe S.
      J. Biol. Chem.275:22769-22779(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SP3
    32. 32.
      "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein."
      Yahata T. , Shao W. , Endoh H. , Hur J. , Coser K.R. , Sun H. , Ueda Y. , Kato S. , Isselbacher K.J. , Brown M. , Shioda T.
      Genes Dev.15:2598-2612(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CITED1 AND EP300
    33. 33.
      "Characterization of the physical interaction between estrogen receptor alpha and JUN proteins."
      Teyssier C. , Belguise K. , Galtier F. , Chalbos D.
      J. Biol. Chem.276:36361-36369(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH JUN; JUNB AND JUND
    34. 34.
      "Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription."
      Chan S.W. , Hong W.
      J. Biol. Chem.276:28402-28412(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDM5A
    35. 35.
      "CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant."
      Sauve F. , McBroom L.D.B. , Gallant J. , Moraitis A.N. , Labrie F. , Giguere V.
      Mol. Cell. Biol.21:343-353(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA5
    36. 36.
      "Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains."
      Metivier R. , Penot G. , Flouriot G. , Pakdel F.
      Mol. Endocrinol.15:1953-1970(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NCOA1 AND DDX5
    37. 37.
      "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."
      Qi C. , Chang J. , Zhu Y. , Yeldandi A.V. , Rao S.M. , Zhu Y.-J.
      J. Biol. Chem.277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRMT2
    38. 38.
      "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor."
      Hu Y.C. , Shyr C.R. , Che W. , Mu X.M. , Kim E. , Chang C.
      J. Biol. Chem.277:33571-33579(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NR2C1
    39. 39.
      "ERAP140, a conserved tissue-specific nuclear receptor coactivator."
      Shao W. , Halachmi S. , Brown M.
      Mol. Cell. Biol.22:3358-3372(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA7
    40. 40.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBFOX2
    41. 41.
      "Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade."
      Wong C.-W. , McNally C. , Nickbarg E. , Komm B.S. , Cheskis B.J.
      Proc. Natl. Acad. Sci. U.S.A.99:14783-14788(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELP1
    42. 42.
      "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation."
      Hsiao P.W. , Fryer C.J. , Trotter K.W. , Wang W. , Archer T.K.
      Mol. Cell. Biol.23:6210-6220(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMARD1
    43. 43.
      "ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor."
      Bu H. , Kashireddy P. , Chang J. , Zhu Y.T. , Zhang Z. , Zheng W. , Rao S.M. , Zhu Y.-J.
      Biochem. Biophys. Res. Commun.317:54-59(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNTTIP2
    44. 44.
      "The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha transcriptional activity depends upon the differentiation stage of the cell."
      Merot Y. , Metivier R. , Penot G. , Manu D. , Saligaut C. , Gannon F. , Pakdel F. , Kah O. , Flouriot G.
      J. Biol. Chem.279:26184-26191(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    45. 45.
      "An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling."
      Damdimopoulos A.E. , Miranda-Vizuete A. , Treuter E. , Gustafsson J.-A. , Spyrou G.
      J. Biol. Chem.279:38721-38729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TXNRD1
    46. 46.
      "Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription."
      Ikeda K. , Ogawa S. , Tsukui T. , Horie-Inoue K. , Ouchi Y. , Kato S. , Muramatsu M. , Inoue S.
      Mol. Endocrinol.18:1131-1143(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-118;DEPHOSPHORYLATION AT SER-118 BY PPP5C;MUTAGENESIS OF SER-118
    47. 47.
      "Estrogen receptor inhibits interleukin-6 gene expression by disruption of nuclear factor kappaB transactivation."
      Liu H. , Liu K. , Bodenner D.L.
      Cytokine31:251-257(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NF-KAPPA-B TRANSREPRESSION
    48. 48.
      "Functional regulation of oestrogen receptor pathway by the dynein light chain 1."
      Rayala S.K. , den Hollander P. , Balasenthil S. , Yang Z. , Broaddus R.R. , Kumar R.
      EMBO Rep.6:538-544(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH DYNLL1
    49. 49.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    50. 50.
      "The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1."
      Wittmann B.M. , Fujinaga K. , Deng H. , Ogba N. , Montano M.M.
      Oncogene24:5576-5588(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HEXIM1
    51. 51.
      "Identification of the MLL2 complex as a coactivator for estrogen receptor alpha."
      Mo R. , Rao S.M. , Zhu Y.-J.
      J. Biol. Chem.281:15714-15720(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KMT2D
    52. 52.
      "Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells."
      Rayala S.K. , den Hollander P. , Manavathi B. , Talukder A.H. , Song C. , Peng S. , Barnekow A. , Kremerskothen J. , Kumar R.
      J. Biol. Chem.281:19092-19099(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    53. 53.
      "MUC1 oncoprotein stabilizes and activates estrogen receptor alpha."
      Wei X. , Xu H. , Kufe D.
      Mol. Cell21:295-305(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MUC1
    54. 54.
      "ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases."
      Lopez-Garcia J. , Periyasamy M. , Thomas R.S. , Christian M. , Leao M. , Jat P. , Kindle K.B. , Heery D.M. , Parker M.G. , Buluwela L. , Kamalati T. , Ali S.
      Nucleic Acids Res.34:6126-6136(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF366
    55. 55.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    56. 56.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    57. 57.
      "An inherent role of microtubule network in the action of nuclear receptor."
      Manavathi B. , Acconcia F. , Rayala S.K. , Kumar R.
      Proc. Natl. Acad. Sci. U.S.A.103:15981-15986(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PBXIP1
    58. 58.
      "The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain."
      Eriksson M. , Samuelsson H. , Samuelsson E.-B. , Liu L. , McKeehan W.L. , Benedikz E. , Sundstroem E.
      Biochem. Biophys. Res. Commun.361:127-132(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP1S
    59. 59.
      "CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome."
      Zhang P.-J. , Zhao J. , Li H.-Y. , Man J.-H. , He K. , Zhou T. , Pan X. , Li A.-L. , Gong W.-L. , Jin B.-F. , Xia Q. , Yu M. , Shen B.-F. , Zhang X.-M.
      EMBO J.26:1831-1842(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CUEDC2
    60. 60.
      "Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity."
      Han W.-D. , Zhao Y.-L. , Meng Y.G. , Zang L. , Wu Z.-Q. , Li Q. , Si Y.-L. , Huang K. , Ba J.-M. , Morinaga H. , Nomura M. , Mu Y.-M.
      Endocr. Relat. Cancer14:741-753(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MACROD1
    61. 61.
      "MS-KIF18A, a kinesin, is associated with estrogen receptor."
      Luboshits G. , Benayahu D.
      J. Cell. Biochem.100:693-702(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH KIF18A
    62. 62.
      "PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor."
      Meyer R. , Wolf S.S. , Obendorf M.
      J. Steroid Biochem. Mol. Biol.107:1-14(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRMT2
    63. 63.
      "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)."
      Gururaj A.E. , Peng S. , Vadlamudi R.K. , Kumar R.
      Mol. Endocrinol.21:1847-1860(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCAS3
    64. 64.
      "Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha."
      Yan J. , Kim Y.S. , Yang X.-P. , Albers M. , Koegl M. , Jetten A.M.
      Nucleic Acids Res.35:1673-1686(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UIMC1
    65. 65.
      "ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification."
      Zou J.X. , Revenko A.S. , Li L.B. , Gemo A.T. , Chen H.-W.
      Proc. Natl. Acad. Sci. U.S.A.104:18067-18072(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATAD2
    66. 66.
      "ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts."
      Lambertini E. , Tavanti E. , Torreggiani E. , Penolazzi L. , Gambari R. , Piva R.
      J. Cell. Physiol.216:101-110(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ASSOCIATION WITH AP-1
    67. 67.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT ARG-260 BY PRMT1;MUTAGENESIS OF ARG-260;SUBCELLULAR LOCATION;INTERACTION WITH PI3KR1/2; SRC AND PTK2/FAK1
    68. 68.
      "CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor."
      Nettles K.W. , Gil G. , Nowak J. , Metivier R. , Sharma V.B. , Greene G.L.
      Mol. Endocrinol.22:263-272(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NF-KAPPA-B TRANSREPRESSION;INTERACTION WITH RELA
    69. 69.
      "MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene."
      Molli P.R. , Singh R.R. , Lee S.W. , Kumar R.
      Oncogene27:1971-1980(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    70. 70.
      "ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells."
      Chen M. , Ni J. , Zhang Y. , Muyan M. , Yeh S.
      Prostate68:1273-1282(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCDC62
    71. 71.
      "SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway."
      Li T. , Li W. , Lu J. , Liu H. , Li Y. , Zhao Y.
      BMB Rep.42:516-522(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2D4A AND PLCG
    72. 72.
      "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer."
      Johnsen S.A. , Guengoer C. , Prenzel T. , Riethdorf S. , Riethdorf L. , Taniguchi-Ishigaki N. , Rau T. , Tursun B. , Furlow J.D. , Sauter G. , Scheffner M. , Pantel K. , Gannon F. , Bach I.
      Cancer Res.69:128-136(2009) [PubMed] [Europe PMC] [Abstract]
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    73. 73.
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      Massinen S. , Tammimies K. , Tapia-Paez I. , Matsson H. , Hokkanen M.E. , Soederberg O. , Landegren U. , Castren E. , Gustafsson J.A. , Treuter E. , Kere J.
      Hum. Mol. Genet.18:2802-2812(2009) [PubMed] [Europe PMC] [Abstract]
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      Gionet N. , Jansson D. , Mader S. , Pratt M.A.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MUTUAL TRANSREPRESSION WITH NF-KAPPA-B;INTERACTION WITH NFKB1 AND RELA
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      Stanisic V. , Malovannaya A. , Qin J. , Lonard D.M. , O'Malley B.W.
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      Nucleic Acids Res.37:3110-3123(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CSNK1D/CK1;INTERACTION WITH CSNK1D
    77. 77.
      "The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer."
      Wortham N.C. , Ahamed E. , Nicol S.M. , Thomas R.S. , Periyasamy M. , Jiang J. , Ochocka A.M. , Shousha S. , Huson L. , Bray S.E. , Coombes R.C. , Ali S. , Fuller-Pace F.V.
      Oncogene28:4053-4064(2009) [PubMed] [Europe PMC] [Abstract]
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      Zusev M. , Benayahu D.
      PLoS ONE4:E6407-E6407(2009) [PubMed] [Europe PMC] [Abstract]
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    79. 79.
      "Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements."
      Pradhan M. , Bembinster L.A. , Baumgarten S.C. , Frasor J.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 3);SUBCELLULAR LOCATION (ISOFORM 3);TOPOLOGY (ISOFORM 3);MUTAGENESIS OF ILE-386
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      Mol. Endocrinol.25:564-574(2011) [PubMed] [Europe PMC] [Abstract]
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      Li S. , Wang M. , Ao X. , Chang A.K. , Yang C. , Zhao F. , Bi H. , Liu Y. , Xiao L. , Wu H.
      Oncogene32:4883-4891(2013) [PubMed] [Europe PMC] [Abstract]
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      Tanenbaum D.M. , Wang Y. , Williams S.P. , Sigler P.B.
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      Cell95:927-937(1998) [PubMed] [Europe PMC] [Abstract]
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      Maalouf G.J. , Xu W. , Smith T. , Mohr S.C.
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      Tora L. , Mullick A. , Metzger D. , Ponglikitmongkol M. , Park I. , Chambon P.
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      "A transcriptionally active estrogen receptor mutant is a novel type of dominant negative inhibitor of estrogen action."
      McInerney E.M. , Ince B.A. , Shapiro D.J. , Katzenellenbogen B.S.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ESTRR GLU-364
    94. 94.
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    95. 95.
      "Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women."
      Becherini L. , Gennari L. , Masi L. , Mansani R. , Massart F. , Morelli A. , Falchetti A. , Gonnelli S. , Fiorelli G. , Tanini A. , Brandi M.L.
      Hum. Mol. Genet.9:2043-2050(2000) [PubMed] [Europe PMC] [Abstract]
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      "G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells."
      Vivacqua A. , Lappano R. , De Marco P. , Sisci D. , Aquila S. , De Amicis F. , Fuqua S.A. , Ando S. , Maggiolini M.
      Mol. Endocrinol.23:1815-1826(2009) [PubMed] [Europe PMC] [Abstract]
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    97. 97.
      "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
      Chanock S.J. , Burdett L. , Yeager M. , Llaca V. , Langeroed A. , Presswalla S. , Kaaresen R. , Strausberg R.L. , Gerhard D.S. , Kristensen V. , Perou C.M. , Boerresen-Dale A.-L.
      Breast Cancer Res.9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TYR-6 AND ILE-264
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      "Delayed puberty and estrogen resistance in a woman with estrogen receptor alpha variant."
      Quaynor S.D. , Stradtman E.W. Jr. , Kim H.G. , Shen Y. , Chorich L.P. , Schreihofer D.A. , Layman L.C.
      N. Engl. J. Med.369:164-171(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ESTRR HIS-375;CHARACTERIZATION OF VARIANT ESTRR HIS-375
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