ESR2 ELISA Kit for Human(Homo sapiens) | EIAab.comESR2 ELISA Kit for Human(Homo sapiens)

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ESR2 (Gene name),

Estrogen receptor beta (Protein name ), ESR2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ESR2(ESTRB;NR3A2);

Protein name:

Estrogen receptor beta(ER-beta);

Alternative:

Nuclear receptor subfamily 3 group A member 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1 and UBE1C. Isoform beta-2/cx preferentially forms a hetereodimer with ESR1 rather than ESR2 and inhibits DNA-binding by ESR1. Interacts with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes, including cyclin-D1/CCND1 AP-1 promoter. Interacts with DYX1C1 (By similarity). Interacts with PRMT2.

Function:

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

530

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

530:

RGCKSSITGS | ECSPAEDSKS | KEGSQNPQSQ |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q92731

UniGene:

Hs.660607

KEGG:

hsa:2100

Pfam:

PF12497

String:

Q92731

MIM:

601663

Uniprot:

Q92731

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ELISA Kit for Human ER-beta

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E2300h

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96T

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ELISA Kit for Human ER-beta

Cat.:

E2300r

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96T

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ELISA Kit for Human ER-beta

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E2300p

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96T

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ELISA Kit for Human ER-beta

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E2300c

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96T

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ELISA Kit for Human ER-beta

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E2300b

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96T

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ELISA Kit for Human ER-beta

Cat.:

E2300m

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96T

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CLIA Kit for Human ER-beta

Cat.:

U2300m

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96T

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CLIA Kit for Human ER-beta

Cat.:

U2300h

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96T

CLIA Kit for Human ER-beta

Cat.:

U2300p

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96T

CLIA Kit for Human ER-beta

Cat.:

U2300b

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96T

CLIA Kit for Human ER-beta

Cat.:

U2300r

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96T

CLIA Kit for Human ER-beta

Cat.:

U2300c

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96T

Polyclonal Antibody for Human ER-beta

Cat.:

P2300Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human ER-beta

Cat.:

P2300Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human ER-beta

Cat.:

P2300Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human ER-beta

Monoclonal Antibody for Human ER-beta

Protein for Human ER-beta

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The complete primary structure of human estrogen receptor beta (hERbeta) and its heterodimerization with ER alpha in vivo and in vitro."
Ogawa S. , Inoue S. , Watanabe T. , Hiroi H. , Orimo A. , Hosoi T. , Ouchi Y. , Muramatsu M.
Biochem. Biophys. Res. Commun.243:122-126(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Cloning and characterization of human estrogen receptor beta isoforms."
Moore J.T. , McKee D.D. , Slentz-Kesler K. , Moore L.B. , Jones S.A. , Horne E.L. , Su J.-L. , Kliewer S.A. , Lehmann J.M. , Willson T.M.
Biochem. Biophys. Res. Commun.247:75-78(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4);NUCLEOTIDE SEQUENCE [MRNA] OF 409-482 (ISOFORM 5);NUCLEOTIDE SEQUENCE [MRNA] OF 409-472 (ISOFORM 6)
tissue: Mammary gland.
tissue: Testis.
3.

"Estrogen receptor-beta mRNA variants in human and murine tissues."
Lu B. , Leygue E. , Dotzlaw H. , Murphy L.J. , Murphy L.C. , Watson P.H.
Mol. Cell. Endocrinol.138:199-203(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Ovary.
4.

"Molecular cloning and characterization of human estrogen receptor beta cx: a potential inhibitor of estrogen action in human."
Ogawa S. , Inoue S. , Watanabe T. , Orimo A. , Hosoi T. , Ouchi Y. , Muramatsu M.
Nucleic Acids Res.26:3505-3512(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);CHARACTERIZATION
tissue: Testis.
5.

"Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling."
Leung Y.K. , Mak P. , Hassan S. , Ho S.M.
Proc. Natl. Acad. Sci. U.S.A.103:13162-13167(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6)
tissue: Prostate.
6.

SeattleSNPs variation discovery resource
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
8.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Testis.
11.

"Cloning and characterization of human estrogen receptor beta promoter."
Li L.C. , Yeh C.C. , Nojima D. , Dahiya R.
Biochem. Biophys. Res. Commun.275:682-689(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69
12.

"ER beta: identification and characterization of a novel human estrogen receptor."
Mosselman S. , Polman J. , Dijkema R.
FEBS Lett.392:49-53(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-530 (ISOFORM 1);CHARACTERIZATION
tissue: Testis.
13.

Brandenberger A.W. , Lebovic D. , Taylor R.N. , Jaffe R.B.
Submitted (1998-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-530 (ISOFORMS 7 AND 8)
tissue: Endometrium.
14.

"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."
Chen H. , Lin R.J. , Schiltz R.L. , Chakravarti D. , Nash A. , Nagy L. , Privalsky M.L. , Nakatani Y. , Evans R.M.
Cell90:569-580(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA3
15.

"Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha."
Pace P. , Taylor J. , Suntharalingam S. , Coombes R.C. , Ali S.
J. Biol. Chem.272:25832-25838(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
16.

"Cloning and characterization of RAP250, a nuclear receptor coactivator."
Caira F. , Antonson P. , Pelto-Huikko M. , Treuter E. , Gustafsson J.-A.
J. Biol. Chem.275:5308-5317(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
17.

"CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant."
Sauve F. , McBroom L.D.B. , Gallant J. , Moraitis A.N. , Labrie F. , Giguere V.
Mol. Cell. Biol.21:343-353(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA5
18.

"The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway."
Driggers P.H. , Segars J.H. , Rubino D.M.
J. Biol. Chem.276:46792-46797(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKAP13
19.

"Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."
Qi C. , Chang J. , Zhu Y. , Yeldandi A.V. , Rao S.M. , Zhu Y.-J.
J. Biol. Chem.277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRMT2
20.

"Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade."
Wong C.-W. , McNally C. , Nickbarg E. , Komm B.S. , Cheskis B.J.
Proc. Natl. Acad. Sci. U.S.A.99:14783-14788(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELP1
21.

"ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor."
Bu H. , Kashireddy P. , Chang J. , Zhu Y.T. , Zhang Z. , Zheng W. , Rao S.M. , Zhu Y.-J.
Biochem. Biophys. Res. Commun.317:54-59(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNTTIP2
22.

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
23.

"An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling."
Damdimopoulos A.E. , Miranda-Vizuete A. , Treuter E. , Gustafsson J.-A. , Spyrou G.
J. Biol. Chem.279:38721-38729(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TXNRD1
24.

"Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway."
St-Laurent V. , Sanchez M. , Charbonneau C. , Tremblay A.
J. Steroid Biochem. Mol. Biol.94:23-37(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-87 AND SER-105;MUTAGENESIS OF SER-87 AND SER-105
25.

"CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells."
Chen M. , Ni J. , Chang H.C. , Lin C.Y. , Muyan M. , Yeh S.
Carcinogenesis30:841-850(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCDC62;SUBCELLULAR LOCATION

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