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Index > Protein center > CES2(Gene name) > Human
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  • CES2 (Gene name),
  • Cocaine esterase (Protein name ),  EST2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CES2(ICE);
    Protein name:
    Cocaine esterase;
    Alternative:
    3.1.1.1;Carboxylesterase 2(CE-2;hCE-2);3.1.1.56;Methylumbelliferyl-acetate deacetylase 2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.
    Subcellular Location:
    Endoplasmic reticulum lumen
    Protein Attributes:
    Sequence length:
    559
    Sequence:
    50:
    MRLHRLRARL | SAVACGLLLL | LVRGQGQDSA | SPIRTTHTGQ | VLGSLVHVKG | 
    100:
    ANAGVQTFLG | IPFAKPPLGP | LRFAPPEPPE | SWSGVRDGTT | HPAMCLQDLT | 
    150:
    AVESEFLSQF | NMTFPSDSMS | EDCLYLSIYT | PAHSHEGSNL | PVMVWIHGGA | 
    200:
    LVFGMASLYD | GSMLAALENV | VVVIIQYRLG | VLGFFSTGDK | HATGNWGYLD | 
    250:
    QVAALRWVQQ | NIAHFGGNPD | RVTIFGESAG | GTSVSSLVVS | PISQGLFHGA | 
    300:
    IMESGVALLP | GLIASSADVI | STVVANLSAC | DQVDSEALVG | CLRGKSKEEI | 
    350:
    LAINKPFKMI | PGVVDGVFLP | RHPQELLASA | DFQPVPSIVG | VNNNEFGWLI | 
    400:
    PKVMRIYDTQ | KEMDREASQA | ALQKMLTLLM | LPPTFGDLLR | EEYIGDNGDP | 
    450:
    QTLQAQFQEM | MADSMFVIPA | LQVAHFQCSR | APVYFYEFQH | QPSWLKNIRP | 
    500:
    PHMKADHGDE | LPFVFRSFFG | GNYIKFTEEE | EQLSRKMMKY | WANFARNGNP | 
    550:
    NGEGLPHWPL | FDQEEQYLQL | NLQPAVGRAL | KAHRLQFWKK | ALPQKIQELE | 
    559:
    EPEERHTEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cocaine esterase
    Cat.:
    E15085h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Cocaine esterase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Cocaine esterase
    Cat.:
    U15085h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cocaine esterase
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Cocaine esterase
    Polyclonal Antibody for Human Cocaine esterase
    Monoclonal Antibody for Human Cocaine esterase
    Monoclonal Antibody for Human Cocaine esterase
    Protein for Human Cocaine esterase
    Protein for Human Cocaine esterase

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver."
      Schwer H. , Langmann T. , Daig R. , Becker A. , Aslanidis C. , Schmitz G.
      Biochem. Biophys. Res. Commun.233:117-120(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Small intestine.
    2. 2.
      "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin."
      Pindel E.V. , Kedishvili N.Y. , Abraham T.L. , Brzezinski M.R. , Zhang J. , Dean R.A. , Bosron W.F.
      J. Biol. Chem.272:14769-14775(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 27-34; 57-70; 227-235; 300-305; 346-351; 447-454; 458-466; 535-540 AND 546-551;FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;GLYCOSYLATION;BIOPHYSICOCHEMICAL PROPERTIES
      tissue: Liver.
    3. 3.
      "Molecular cloning and expression of a human liver cDNA encoding a novel carboxylesterase."
      Sone T. , Ishida Y. , Takabatake E. , Wang C. , Pohl L. , Isobe M.
      Submitted (1997-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Endometrial adenocarcinoma.
      tissue: Testis.
    6. 6.
      NIEHS SNPs program
      Submitted (2004-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skin.
    9. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-111
      tissue: Liver.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."
      Saito S. , Iida A. , Sekine A. , Kawauchi S. , Higuchi S. , Ogawa C. , Nakamura Y.
      J. Hum. Genet.48:249-270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-206
    12. 12.
      "Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2)."
      Kim S.-R. , Nakamura T. , Saito Y. , Sai K. , Nakajima T. , Saito H. , Shirao K. , Minami H. , Ohtsu A. , Yoshida T. , Saijo N. , Ozawa S. , Sawada J.
      Drug Metab. Pharmacokinet.18:327-332(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-34
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