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Index > Protein center > ETFB(Gene name) > Human
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  • ETFB (Gene name),
  • Electron transfer flavoprotein subunit beta (Protein name ),  ETFB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ETFB(FP585);
    Protein name:
    Electron transfer flavoprotein subunit beta(Beta-ETF);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit.
    Function:
    The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    255
    Sequence:
    50:
    MAELRVLVAV | KRVIDYAVKI | RVKPDRTGVV | TDGVKHSMNP | FCEIAVEEAV | 
    100:
    RLKEKKLVKE | VIAVSCGPAQ | CQETIRTALA | MGADRGIHVE | VPPAEAERLG | 
    150:
    PLQVARVLAK | LAEKEKVDLV | LLGKQAIDDD | CNQTGQMTAG | FLDWPQGTFA | 
    200:
    SQVTLEGDKL | KVEREIDGGL | ETLRLKLPAV | VTADLRLNEP | RYATLPNIMK | 
    250:
    AKKKKIEVIK | PGDLGVDLTS | KLSVISVEDP | PQRTAGVKVE | TTEDLVAKLK | 
    255:
    EIGRI
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    KEGG:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Beta-ETF
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    Packing:
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    Polyclonal Antibody for Human Beta-ETF
    Monoclonal Antibody for Human Beta-ETF
    Monoclonal Antibody for Human Beta-ETF
    Monoclonal Antibody for Human Beta-ETF
    Monoclonal Antibody for Human Beta-ETF
    Monoclonal Antibody for Human Beta-ETF
    Protein for Human Beta-ETF
    Protein for Human Beta-ETF
    Protein for Human Beta-ETF
    Protein for Human Beta-ETF
    Protein for Human Beta-ETF

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein."
      Finocchiaro G. , Colombo I. , Garavaglia B. , Gellera C. , Valdameri G. , Garbuglio N. , Didonato S.
      Eur. J. Biochem.213:1003-1008(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal liver.
    2. 2.
      "Clear relationship between ETF/ETFDH genotype and phenotype in patients with multiple acyl-CoA dehydrogenation deficiency."
      Olsen R.K.J. , Andresen B.S. , Christensen E. , Bross P. , Skovby F. , Gregersen N.
      Hum. Mutat.22:12-23(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GA2B ASN-128
    3. 3.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT MET-154
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT MET-154
      tissue: Brain.
      tissue: Skeletal muscle.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cerebellum.
    7. 7.
      "Mutations and polymorphisms of the gene encoding the beta-subunit of the electron transfer flavoprotein in three patients with glutaric acidemia type II."
      Colombo I. , Finocchiaro G. , Garavaglia B. , Garbuglio N. , Yamaguchi S. , Frerman F. , Berra B. , Didonato S.
      Hum. Mol. Genet.3:429-435(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-199;VARIANT GA2B GLN-164
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria."
      Rhein V.F. , Carroll J. , He J. , Ding S. , Fearnley I.M. , Walker J.E.
      J. Biol. Chem.289:24640-24651(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT LYS-200 AND LYS-203
    10. 10.
      "Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution."
      Roberts D.L. , Frerman F.E. , Kim J.-J.P.
      Proc. Natl. Acad. Sci. U.S.A.93:14355-14360(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH ETFA;COFACTORS;SUBUNIT;FAD BINDING SITES
    11. 11.
      "Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain acyl-CoA dehydrogenase complex."
      Toogood H.S. , van Thiel A. , Basran J. , Sutcliffe M.J. , Scrutton N.S. , Leys D.
      J. Biol. Chem.279:32904-32912(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) IN COMPLEX WITH ETFA AND ACADM;MUTAGENESIS OF LEU-195
    12. 12.
      "Stabilization of non-productive conformations underpins rapid electron transfer to electron-transferring flavoprotein."
      Toogood H.S. , van Thiel A. , Scrutton N.S. , Leys D.
      J. Biol. Chem.280:30361-30366(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.11 ANGSTROMS) OF MUTANT ALA-165 IN COMPLEX WITH ETFA AND ACADM;MUTAGENESIS OF GLU-165
    13. 13.
      "A polymorphic variant in the human electron transfer flavoprotein alpha-chain (alpha-T171) displays decreased thermal stability and is overrepresented in very-long-chain acyl-CoA dehydrogenase-deficient patients with mild childhood presentation."
      Bross P. , Pedersen P. , Winter V. , Nyholm M. , Johansen B.N. , Olsen R.K. , Corydon M.J. , Andresen B.S. , Eiberg H. , Kolvraa S. , Gregersen N.
      Mol. Genet. Metab.67:138-147(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-154
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