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Index > Protein center > Fabp4(Gene name) > Mouse
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  • Fabp4 (Gene name),
  • Fatty acid-binding protein, adipocyte (Protein name ),  FABP4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Fabp4(Ap2);
    Protein name:
    Fatty acid-binding protein, adipocyte;
    Alternative:
    Adipocyte lipid-binding protein(ALBP);3T3-L1 lipid-binding protein;Fatty acid-binding protein 4;Adipocyte-type fatty acid-binding protein(A-FABP;AFABP);P15;Myelin P2 protein homolog;Protein 422;P2 adipocyte protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer (By similarity). Homodimer. Interacts with PPARG.
    Function:
    Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
    Subcellular Location:
    Cytoplasm Nucleus Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.
    Protein Attributes:
    Sequence length:
    132
    Sequence:
    50:
    MCDAFVGTWK | LVSSENFDDY | MKEVGVGFAT | RKVAGMAKPN | MIISVNGDLV | 
    100:
    TIRSESTFKN | TEISFKLGVE | FDEITADDRK | VKSIITLDGG | ALVQVQKWDG | 
    132:
    KSTTIKRKRD | GDKLVVECVM | KGVTSTRVYE | RA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Fatty acid-binding protein, adipocyte
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    ELISA Kit for Mouse Fatty acid-binding protein, adipocyte
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    E0184r
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    ELISA Kit for Mouse Fatty acid-binding protein, adipocyte
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    ELISA Kit for Mouse Fatty acid-binding protein, adipocyte
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    E0184p
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    96T
    ELISA Kit for Mouse Fatty acid-binding protein, adipocyte
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    E0184b
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    96T
    CLIA Kit for Mouse Fatty acid-binding protein, adipocyte
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    U0184p
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    96T
    CLIA Kit for Mouse Fatty acid-binding protein, adipocyte
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    CLIA Kit for Mouse Fatty acid-binding protein, adipocyte
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    U0184r
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    CLIA Kit for Mouse Fatty acid-binding protein, adipocyte
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    U0184h
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    CLIA Kit for Mouse Fatty acid-binding protein, adipocyte
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    U0184b
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    Packing:
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    Polyclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
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    P0184Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
    Polyclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
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    P0184Rb-h
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    Packing:
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    Polyclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
    Polyclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
    Monoclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
    Monoclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
    Monoclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
    Monoclonal Antibody for Mouse Fatty acid-binding protein, adipocyte
    Protein for Mouse Fatty acid-binding protein, adipocyte
    Protein for Mouse Fatty acid-binding protein, adipocyte
    Protein for Mouse Fatty acid-binding protein, adipocyte
    Protein for Mouse Fatty acid-binding protein, adipocyte
    Protein for Mouse Fatty acid-binding protein, adipocyte
    Cat.:
    R0184h
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    Packing:
    1mg
    Purity:
    >90%

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    References
    1. 1.
      "Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein."
      Bernlohr D.A. , Angus C.W. , Lane M.D. , Bolanowski M.A. , Kelly T.J. Jr.
      Proc. Natl. Acad. Sci. U.S.A.81:5468-5472(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes."
      Hunt C.R. , Ro J.H.-S. , Dobson D.E. , Min H.Y. , Spiegelman B.M.
      Proc. Natl. Acad. Sci. U.S.A.83:3786-3790(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The nucleotide sequence of three genes participating in the adipose differentiation of 3T3 cells."
      Phillips M. , Djian P. , Green H.
      J. Biol. Chem.261:10821-10827(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Mammary gland.
    6. 6.
      "Purification of murine adipocyte lipid-binding protein. Characterization as a fatty acid- and retinoic acid-binding protein."
      Matarese V. , Bernlohr D.A.
      J. Biol. Chem.263:14544-14551(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-132
    7. 7.
      "Expression of the differentiation-induced gene for fatty acid-binding protein is activated by glucocorticoid and cAMP."
      Cook J.S. , Lucas J.J. , Sibley E. , Bolanowski M.A. , Christy R.J. , Kelly T.J. Jr. , Lane M.D.
      Proc. Natl. Acad. Sci. U.S.A.85:2949-2953(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11
    8. 8.
      "Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control."
      Cook K.S. , Hunt C.R. , Spiegelman B.M.
      J. Cell Biol.100:514-520(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-132
    9. 9.
      "Expression of fatty acid-binding proteins in the developing mouse mammary gland."
      Bansal M.P. , Medina D.
      Biochem. Biophys. Res. Commun.191:61-69(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-35; 37-51 AND 59-88
      tissue: Mammary gland.
    10. 10.
      "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription."
      Tan N.-S. , Shaw N.S. , Vinckenbosch N. , Liu P. , Yasmin R. , Desvergne B. , Wahli W. , Noy N.
      Mol. Cell. Biol.22:5114-5127(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PPARG
    11. 11.
      "Adipocyte-type fatty acid-binding protein as inter-compartmental shuttle for peroxisome proliferator activated receptor gamma agonists in cultured cell."
      Adida A. , Spener F.
      Biochim. Biophys. Acta1761:172-181(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PPARG
    12. 12.
      "Continuous nucleocytoplasmic shuttling underlies transcriptional activation of PPARgamma by FABP4."
      Ayers S.D. , Nedrow K.L. , Gillilan R.E. , Noy N.
      Biochemistry46:6744-6752(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-22; ARG-31; LYS-32; LEU-67; LEU-87 AND LEU-92
    13. 13.
      "Crystal structure of recombinant murine adipocyte lipid-binding protein."
      Xu Z. , Bernlohr D.A. , Banaszak L.J.
      Biochemistry31:3484-3492(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
    14. 14.
      "The adipocyte lipid-binding protein at 1.6-A resolution. Crystal structures of the apoprotein and with bound saturated and unsaturated fatty acids."
      Xu Z. , Bernlohr D.A. , Banaszak L.J.
      J. Biol. Chem.268:7874-7884(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS)
    15. 15.
      "Studies of the ligand binding reaction of adipocyte lipid binding protein using the fluorescent probe 1, 8-anilinonaphthalene-8-sulfonate."
      Ory J.J. , Banaszak L.J.
      Biophys. J.77:1107-1116(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
    16. 16.
      "X-ray crystallographic structures of adipocyte lipid-binding protein complexed with palmitate and hexadecanesulfonic acid. Properties of cavity binding sites."
      LaLonde J.M. , Bernlohr D.A. , Banaszak L.J.
      Biochemistry33:4885-4895(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH FATTY ACID
    17. 17.
      "Adipocyte lipid-binding protein complexed with arachidonic acid. Titration calorimetry and X-ray crystallographic studies."
      LaLonde J.M. , Levenson M.A. , Roe J.J. , Bernlohr D.A. , Banaszak L.J.
      J. Biol. Chem.269:25339-25347(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH FATTY ACID
    18. 18.
      "Specificity determinants for lipids bound to beta-barrel proteins."
      Reese A.J. , Banaszak L.J.
      J. Lipid Res.45:232-243(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) IN COMPLEX WITH FATTY ACID
    19. 19.
      "Structural basis for activation of fatty acid-binding protein 4."
      Gillilan R.E. , Ayers S.D. , Noy N.
      J. Mol. Biol.372:1246-1260(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEXES WITH TROGLITAZONE AND LINOLEIC ACID;SUBUNIT;MUTAGENESIS OF PHE-58; LEU-67; LEU-87 AND LEU-92;SUBCELLULAR LOCATION
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