Protein name:
Fatty acid desaturase 2 ;
Alternative:
Delta(6) fatty acid desaturase (D6D;Delta(6) desaturase;Delta-6 desaturase) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Protein Attributes:
50:
MGKGGNQGEG | AAEREVSVPT | FSWEEIQKHN | LRTDRWLVID | RKVYNITKWS |
100:
IQHPGGQRVI | GHYAGEDATD | AFRAFHPDLE | FVGKFLKPLL | IGELAPEEPS |
150:
QDHGKNSKIT | EDFRALRKTA | EDMNLFKTNH | VFFLLLLAHI | IALESIAWFT |
200:
VFYFGNGWIP | TLITAFVLAT | SQAQAGWLQH | DYGHLSVYRK | PKWNHLVHKF |
250:
VIGHLKGASA | NWWNHRHFQH | HAKPNIFHKD | PDVNMLHVFV | LGEWQPIEYG |
300:
KKKLKYLPYN | HQHEYFFLIG | PPLLIPMYFQ | YQIIMTMIVH | KNWVDLAWAV |
350:
SYYIRFFITY | IPFYGILGAL | LFLNFIRFLE | SHWFVWVTQM | NHIVMEIDQE |
400:
AYRDWFSSQL | TATCNVEQSF | FNDWFSGHLN | FQIEHHLFPT | MPRHNLHKIA |
444:
PLVKSLCAKH | GIEYQEKPLL | RALLDIIRSL | KKSGKLWLDA | YLHK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
ELISA Kit for Human Fatty acid desaturase 2
ELISA Kit for Human Fatty acid desaturase 2
ELISA Kit for Human Fatty acid desaturase 2
ELISA Kit for Human Fatty acid desaturase 2
CLIA Kit for Human Fatty acid desaturase 2
CLIA Kit for Human Fatty acid desaturase 2
CLIA Kit for Human Fatty acid desaturase 2
CLIA Kit for Human Fatty acid desaturase 2
Polyclonal Antibody for Human Fatty acid desaturase 2
Polyclonal Antibody for Human Fatty acid desaturase 2
Polyclonal Antibody for Human Fatty acid desaturase 2
Polyclonal Antibody for Human Fatty acid desaturase 2
Monoclonal Antibody for Human Fatty acid desaturase 2
Monoclonal Antibody for Human Fatty acid desaturase 2
Monoclonal Antibody for Human Fatty acid desaturase 2
Monoclonal Antibody for Human Fatty acid desaturase 2
Protein for Human Fatty acid desaturase 2
Protein for Human Fatty acid desaturase 2
Protein for Human Fatty acid desaturase 2
Protein for Human Fatty acid desaturase 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 277-444 (ISOFORMS 1/2)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]