PTK2 ELISA Kit for Human(Homo sapiens) | EIAab.comPTK2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PTK2(Gene name) > Human

PTK2 (Gene name),

Focal adhesion kinase 1 (Protein name ), FAK1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PTK2(FAK;FAK1);

Protein name:

Focal adhesion kinase 1(FADK 1);

Alternative:

pp125FAK(PPP1R71);Protein-tyrosine kinase 2(FRNK);p125FAK;Protein-tyrosine kinase 2;pp125FAK;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with CAS family members. Interacts with GIT1. Interacts with SORBS1. Interacts with BCAR3. Interacts with RGNEF. Interacts with SHB. Interacts with PXN (By similarity). Component of a complex that contains at least FER, CTTN and PTK2/FAK. Interacts with BMX. Interacts with TGFB1I1. Interacts with STEAP4. Interacts with ZFYVE21. Interacts with ESR1. Interacts with PIK3R1 or PIK3R2. Interacts with SRC. Interacts with EPHA2 (inactive form); participates to EPHA2 downstream signaling. Interacts with CD4; this interaction requires the presence of HIV-1 gp120. Interacts with EPHA1 (kinase activity-dependent).

Function:

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Subcellular Location:

Cell junction focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Constituent of focal adhesions.

Protein Attributes:

Sequence length:

1052

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1052:

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000341189

MIM:

600758

SMR:

Q05397

UniGene:

Hs.395482

String:

Q05397

KEGG:

hsa:5747

Pfam:

PF00373

Uniprot:

Q05397

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ELISA Kit for Human FADK 1

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E1178c

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96T

ELISA Kit for Human FADK 1

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E1178h

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ELISA Kit for Human FADK 1

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E1178r

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ELISA Kit for Human FADK 1

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E1178m

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96T

CLIA Kit for Human FADK 1

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U1178h

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CLIA Kit for Human FADK 1

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U1178c

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96T

CLIA Kit for Human FADK 1

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U1178r

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96T

CLIA Kit for Human FADK 1

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U1178m

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Polyclonal Antibody for Human FADK 1

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P1178Rb-m

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Polyclonal Antibody for Human FADK 1

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P1178Rb-r

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Polyclonal Antibody for Human FADK 1

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P1178Rb-h

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Monoclonal Antibody for Human FADK 1

Protein for Human FADK 1

R&D Technical Data

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Precision

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Recovery

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References

1.

"Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK."
Whitney G.S. , Chan P.Y. , Blake J. , Cosand W.L. , Neubauer M.G. , Aruffo A. , Kanner S.B.
DNA Cell Biol.12:823-830(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: T-cell.
2.

"Expression of an N-terminally truncated form of human focal adhesion kinase in brain."
Andre E. , Becker-Andre M.
Biochem. Biophys. Res. Commun.190:140-147(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);TISSUE SPECIFICITY
tissue: Brain.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
tissue: Trachea.
4.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
tissue: Placenta.
6.

Bienvenut W.V. , Glen H. , Brunton V.G. , Frame M.C.
Submitted (2007-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-19; 192-199; 222-236; 243-252; 350-364; 414-419; 468-476; 562-569; 674-690; 798-811; 832-838; 904-933; 963-981; 989-1000 AND 1003-1042;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Osteosarcoma.
7.

"A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes."
Lee S.-T. , Strunk K.M. , Spritz R.A.
Oncogene8:3403-3410(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 552-602;TISSUE SPECIFICITY
tissue: Melanocyte.
8.

"Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions."
Matsuya M. , Sasaki H. , Aoto H. , Mitaka T. , Nagura K. , Ohba T. , Ishino M. , Takahashi S. , Suzuki R. , Sasaki T.
J. Biol. Chem.273:1003-1014(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
9.

"Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase."
Fujita H. , Kamiguchi K. , Cho D. , Shibanuma M. , Morimoto C. , Tachibana K.
J. Biol. Chem.273:26516-26521(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1;MUTAGENESIS OF VAL-928 AND LEU-1034
10.

"Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation."
Miao H. , Burnett E. , Kinch M. , Simon E. , Wang B.
Nat. Cell Biol.2:62-69(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PXN PHOSPHORYLATION; REGULATION OF CELL SHAPE AND MIGRATION;INTERACTION WITH EPHA2;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;ENZYME REGULATION;DEPHOSPHORYLATION BY PTPN11;SUBCELLULAR LOCATION
11.

"Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain."
Chen R. , Kim O. , Li M. , Xiong X. , Guan J.L. , Kung H.J. , Chen H. , Shimizu Y. , Qiu Y.
Nat. Cell Biol.3:439-444(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION AND ACTIVATION OF BMX;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;MUTAGENESIS OF TYR-397;INTERACTION WITH BMX
12.

"Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples."
Hecker T.P. , Grammer J.R. , Gillespie G.Y. , Stewart J. Jr. , Gladson C.L.
Cancer Res.62:2699-2707(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SHC1;AUTOPHOSPHORYLATION;INTERACTION WITH SHC1 AND SRC;ROLE IN DISEASE
13.

"Regulation of focal adhesion kinase by a novel protein inhibitor FIP200."
Abbi S. , Ueda H. , Zheng C. , Cooper L.A. , Zhao J. , Christopher R. , Guan J.L.
Mol. Biol. Cell13:3178-3191(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RB1CC1
14.

"Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein."
Relou I.A.M. , Bax L.A.B. , Van Rijn H.J.M. , Akkerman J.-W.N.
Biochem. J.369:407-416(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-397; TYR-407; TYR-577; TYR-861 AND TYR-925;INTERACTION WITH FGR
15.

"Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway."
Xia H. , Nho R.S. , Kahm J. , Kleidon J. , Henke C.A.
J. Biol. Chem.279:33024-33034(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTEGRIN SIGNALING; REGULATION OF APOPTOSIS; REGULATION OF CELL SHAPE AND ACTIVATION OF PHOSPHATIDYLINOSITOL KINASE AND AKT1 SIGNALING PATHWAY
16.

"The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization."
Continolo S. , Baruzzi A. , Majeed M. , Caveggion E. , Fumagalli L. , Lowell C.A. , Berton G.
Exp. Cell Res.302:253-269(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF CELL MIGRATION;PHOSPHORYLATION AT TYR-407; TYR-397 AND TYR-576
17.

"Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53."
Golubovskaya V.M. , Finch R. , Cance W.G.
J. Biol. Chem.280:25008-25021(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH P53/TP53;SUBCELLULAR LOCATION
18.

"Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase."
Ezratty E.J. , Partridge M.A. , Gundersen G.G.
Nat. Cell Biol.7:581-590(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN FOCAL ADHESION DISASSEMBLY
19.

"Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells."
Garces C.A. , Kurenova E.V. , Golubovskaya V.M. , Cance W.G.
Cancer Res.66:1446-1454(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLT4
20.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"Expression of FAK-related non-kinase (FRNK) coincides with morphological change in the early stage of cell adhesion."
Nagoshi Y. , Yamamoto G. , Irie T. , Tachikawa T.
Med. Mol. Morphol.39:154-160(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE PROMOTER USAGE;IDENTIFICATION OF ISOFORM 6;DEVELOPMENTAL STAGE (ISOFORM 6)
22.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
23.

"Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma."
Halder J. , Lin Y.G. , Merritt W.M. , Spannuth W.A. , Nick A.M. , Honda T. , Kamat A.A. , Han L.Y. , Kim T.J. , Lu C. , Tari A.M. , Bornmann W. , Fernandez A. , Lopez-Berestein G. , Sood A.K.
Cancer Res.67:10976-10983(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;ROLE IN DISEASE;PHOSPHORYLATION AT TYR-397 AND TYR-861
24.

"Cellular characterization of a novel focal adhesion kinase inhibitor."
Slack-Davis J.K. , Martin K.H. , Tilghman R.W. , Iwanicki M. , Ung E.J. , Autry C. , Luzzio M.J. , Cooper B. , Kath J.C. , Roberts W.G. , Parsons J.T.
J. Biol. Chem.282:14845-14852(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;ROLE IN DISEASE;PHOSPHORYLATION AT TYR-397
25.

"Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5."
Salasznyk R.M. , Klees R.F. , Boskey A. , Plopper G.E.
J. Cell. Biochem.100:499-514(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN OSTEOBLAST DIFFERENTIATION
26.

"Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo."
Liu T.J. , LaFortune T. , Honda T. , Ohmori O. , Hatakeyama S. , Meyer T. , Jackson D. , de Groot J. , Yung W.K.
Mol. Cancer Ther.6:1357-1367(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;ROLE IN DISEASE;PHOSPHORYLATION AT TYR-397
27.

"The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription."
Sundberg-Smith L.J. , DiMichele L.A. , Sayers R.L. , Mack C.P. , Taylor J.M.
Circ. Res.102:1502-1511(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LPXN
28.

"Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways."
Semaan N. , Alsaleh G. , Gottenberg J.E. , Wachsmann D. , Sibilia J.
J. Immunol.180:3485-3491(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BMX
29.

"A novel Cas family member, HEPL, regulates FAK and cell spreading."
Singh M.K. , Dadke D. , Nicolas E. , Serebriiskii I.G. , Apostolou S. , Canutescu A. , Egleston B.L. , Golemis E.A.
Mol. Biol. Cell19:1627-1636(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CASS4
30.

"Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation."
Lim S.T. , Chen X.L. , Lim Y. , Hanson D.A. , Vo T.T. , Howerton K. , Larocque N. , Fisher S.J. , Schlaepfer D.D. , Ilic D.
Mol. Cell29:9-22(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF P53/TP53 LEVELS; CELL PROLIFERATION AND CELL SURVIVAL;SUBCELLULAR LOCATION
31.

"Regulation of estrogen rapid signaling through arginine methylation by PRMT1."
Le Romancer M. , Treilleux I. , Leconte N. , Robin-Lespinasse Y. , Sentis S. , Bouchekioua-Bouzaghou K. , Goddard S. , Gobert-Gosse S. , Corbo L.
Mol. Cell31:212-221(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ESR1; PIK3R1 AND/OR PIK3R2 AND SRC
32.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-13; SER-29; SER-887 AND SER-910;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
33.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
34.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
35.

"Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes."
Oh M.A. , Choi S. , Lee M.J. , Choi M.C. , Lee S.A. , Ko W. , Cance W.G. , Oh E.S. , Buday L. , Kim S.H. , Lee J.W.
Biochim. Biophys. Acta1793:781-791(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-397; TYR-576; TYR-577; SER-722; TYR-861 AND TYR-925;IDENTIFICATION IN A COMPLEX WITH CTTN AND FER
36.

"Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion."
Sachdev S. , Bu Y. , Gelman I.H.
BMC Cancer9:12-12(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SRC-MEDIATED PHOSPHORYLATION OF PXN
37.

"STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells."
Tamura T. , Chiba J.
Int. J. Mol. Med.24:599-604(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STEAP4
38.

"Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling."
Pylayeva Y. , Gillen K.M. , Gerald W. , Beggs H.E. , Reichardt L.F. , Giancotti F.G.
J. Clin. Invest.119:252-266(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SRC-MEDIATED PHOSPHORYLATION OF BCAR1;ROLE IN DISEASE
39.

"EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility."
Yamazaki T. , Masuda J. , Omori T. , Usui R. , Akiyama H. , Maru Y.
J. Cell Sci.122:243-255(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHA1
40.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-5; THR-13; SER-29; TYR-397; TYR-570; SER-580 AND SER-910;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
41.

"Bioluminescent imaging study: FAK inhibitor, PF-562,271, preclinical study in PC3M-luc-C6 local implant and metastasis xenograft models."
Sun H. , Pisle S. , Gardner E.R. , Figg W.D.
Cancer Biol. Ther.10:38-43(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN DISEASE;ENZYME REGULATION
42.

"LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin."
Tanaka T. , Moriwaki K. , Murata S. , Miyasaka M.
Cancer Sci.101:363-368(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LPXN
43.

"Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts."
Cai G.Q. , Zheng A. , Tang Q. , White E.S. , Chou C.F. , Gladson C.L. , Olman M.A. , Ding Q.
Exp. Cell Res.316:1600-1609(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 6);TISSUE SPECIFICITY
44.

"ZF21 protein regulates cell adhesion and motility."
Nagano M. , Hoshino D. , Sakamoto T. , Kawasaki N. , Koshikawa N. , Seiki M.
J. Biol. Chem.285:21013-21022(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZFYVE21;DEPHOSPHORYLATION AT TYR-397
45.

"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
Stewart C.R. , Stuart L.M. , Wilkinson K. , van Gils J.M. , Deng J. , Halle A. , Rayner K.J. , Boyer L. , Zhong R. , Frazier W.A. , Lacy-Hulbert A. , El Khoury J. , Golenbock D.T. , Moore K.J.
Nat. Immunol.11:155-161(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD36
46.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910 AND THR-914;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
47.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
48.

"Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism."
Plaza-Menacho I. , Morandi A. , Mologni L. , Boender P. , Gambacorti-Passerini C. , Magee A.I. , Hofstra R.M.W. , Knowles P. , McDonald N.Q. , Isacke C.M.
J. Biol. Chem.286:17292-17302(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RET;FUNCTION IN RET PHOSPHORYLATION;PHOSPHORYLATION AT TYR-576 AND TYR-577
49.

"A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis."
Armacki M. , Joodi G. , Nimmagadda S.C. , de Kimpe L. , Pusapati G.V. , Vandoninck S. , Van Lint J. , Illing A. , Seufferlein T.
Oncogene33:1167-1180(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CIB1 ISOFORM 2
tissue: Brain.
50.

"Signaling through focal adhesion kinase."
Schlaepfer D.D. , Hauck C.R. , Sieg D.J.
Prog. Biophys. Mol. Biol.71:435-478(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON SIGNALING AND ON DIRECT PTK2/FAK1 SUBSTRATES
51.

"Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning."
Nikolopoulos S.N. , Giancotti F.G.
Cell Cycle4:E131-E135(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN NETRIN SIGNALING
52.

"Integrin-regulated FAK-Src signaling in normal and cancer cells."
Mitra S.K. , Schlaepfer D.D.
Curr. Opin. Cell Biol.18:516-523(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN CELL MIGRATION; FOCAL ADHESION TURNOVER AND ACTIVATION OF SIGNALING PATHWAYS;ROLE IN DISEASE
53.

"Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions."
Vadali K. , Cai X. , Schaller M.D.
IUBMB Life59:709-716(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
54.

"FERM control of FAK function: implications for cancer therapy."
Lim S.T. , Mikolon D. , Stupack D.G. , Schlaepfer D.D.
Cell Cycle7:2306-2314(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN INTEGRIN SIGNALING AND IN REGULATION OF P53/TP53 ACTIVITIES;ROLE IN DISEASE;ENZYME REGULATION
55.

"Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility."
Tomar A. , Schlaepfer D.D.
Curr. Opin. Cell Biol.21:676-683(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN REGULATION OF RHO FAMILY GTPASE ACTIVITY
56.

"Focal adhesion kinase and cancer."
Golubovskaya V.M. , Kweh F.A. , Cance W.G.
Histol. Histopathol.24:503-510(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON EXPRESSION IN CANCER;ROLE IN DISEASE
57.

"Focal adhesion kinase and p53 signal transduction pathways in cancer."
Golubovskaya V.M. , Cance W.
Front. Biosci.15:901-912(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN REGULATION OF P53/TP53
58.

"The role of focal adhesion kinase in early development."
Chatzizacharias N.A. , Kouraklis G.P. , Theocharis S.E.
Histol. Histopathol.25:1039-1055(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN DEVELOPMENT
59.

"Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer."
Guan J.L.
IUBMB Life62:268-276(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN INTEGRIN SIGNALING AND ACTIVATION OF DOWNSTREAM SIGNALING PATHWAYS
60.

"Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions."
Schaller M.D.
J. Cell Sci.123:1007-1013(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SIGNALING
61.

"Focal adhesion kinase: exploring Fak structure to gain insight into function."
Hall J.E. , Fu W. , Schaller M.D.
Int. Rev. Cell Mol. Biol.288:185-225(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; SUBUNIT; PHOSPHORYLATION; ENZYME REGULATION AND ROLE IN DISEASE
62.

"MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression."
Zhu M. , Settele F. , Kotak S. , Sanchez-Pulido L. , Ehret L. , Ponting C.P. , Goenczy P. , Hoffmann I.
J. Cell Biol.200:773-787(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MISP
63.

"The structural basis of localization and signaling by the focal adhesion targeting domain."
Arold S.T. , Hoellerer M.K. , Noble M.E.
Structure10:319-327(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 891-1052;IDENTIFICATION BY MASS SPECTROMETRY
64.

"Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography."
Nowakowski J. , Cronin C.N. , McRee D.E. , Knuth M.W. , Nelson C.G. , Pavletich N.P. , Rogers J. , Sang B.C. , Scheibe D.N. , Swanson R.V. , Thompson D.A.
Structure10:1659-1667(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 411-686 IN COMPLEX WITH ATP
65.

"Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain."
Hoellerer M.K. , Noble M.E. , Labesse G. , Campbell I.D. , Werner J.M. , Arold S.T.
Structure11:1207-1217(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 892-1052 IN COMPLEX WITH PXN;INTERACTION WITH PXN
66.

"Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271."
Roberts W.G. , Ung E. , Whalen P. , Cooper B. , Hulford C. , Autry C. , Richter D. , Emerson E. , Lin J. , Kath J. , Coleman K. , Yao L. , Martinez-Alsina L. , Lorenzen M. , Berliner M. , Luzzio M. , Patel N. , Schmitt E. , more...
Cancer Res.68:1935-1944(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 414-689 IN COMPLEX WITH INHIBITOR;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION
67.

"Structural basis for the interaction between focal adhesion kinase and CD4."
Garron M.L. , Arthos J. , Guichou J.F. , McNally J. , Cicala C. , Arold S.T.
J. Mol. Biol.375:1320-1328(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.82 ANGSTROMS) OF 891-1052 IN COMPLEX WITH CD4;SUBCELLULAR LOCATION;INTERACTION WITH CD4
68.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-292; GLN-292; ALA-793; GLU-1030 AND GLU-1044

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