FBLN1 ELISA Kit for Human(Homo sapiens) | EIAab.comFBLN1 ELISA Kit for Human(Homo sapiens)

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FBLN1 (Gene name),

Fibulin-1 (Protein name ), FBLN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

FBLN1(PP213);

Protein name:

Fibulin-1(FIBL-1);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen. Interacts also with APP, NOV, FGB and HPV type 16, HPV type 18, HPV type 31 and BPV type 1 E6 proteins. Interacts with FBLN7.

Function:

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

703

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

703:

YWF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P23142

UniGene:

Hs.24601

KEGG:

hsa:2192

Pfam:

PF01821

SMR:

P23142

MIM:

135820

Uniprot:

P23142

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ELISA Kit for Human FIBL-1

Cat.:

E0136m

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96T

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ELISA Kit for Human FIBL-1

Cat.:

E0136h

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96T

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ELISA Kit for Human FIBL-1

Cat.:

E0136c

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Packing:

96T

CLIA Kit for Human FIBL-1

Cat.:

U0136h

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Manual:

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96T

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CLIA Kit for Human FIBL-1

Cat.:

U0136c

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MSDS:

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Packing:

96T

CLIA Kit for Human FIBL-1

Cat.:

U0136m

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Packing:

96T

Polyclonal Antibody for Human FIBL-1

Cat.:

P0136Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human FIBL-1

Cat.:

P0136Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human FIBL-1

Protein for Human FIBL-1

Cat.:

R0136h

Price:

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Fibulin-1 is associated with cardiovascular risk in non-obese, non-diabetic individuals"

K Bergmann, A Mańkowska-Cyl, Marek Kretowicz, et al.

From:Folia Medica Copernicana

References

1.

"Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure."
Argraves W.S. , Tran H. , Burgess W.H. , Dickerson K.
J. Cell Biol.111:3155-3164(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C);VARIANT ARG-141
2.

"Human fibulin-1D: molecular cloning, expression and similarity with S1-5 protein, a new member of the fibulin gene family."
Tran H. , Mattei M.-G. , Godyna S. , Argraves W.S.
Matrix Biol.15:479-493(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D);TISSUE SPECIFICITY;VARIANT ARG-141;INTERACTION WITH FN1 AND FGB
3.

"Translational control of specific genes during differentiation of HL-60 cells."
Krichevsky A.M. , Metzer E. , Rosen H.
J. Biol. Chem.274:14295-14305(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D);VARIANTS ARG-141 AND ARG-695
4.

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C);VARIANT ARG-141
5.

"The DNA sequence of human chromosome 22."
Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C);VARIANT ARG-141
tissue: Brain.
7.

"Structural and functional characterization of the human and mouse fibulin-1 gene promoters: role of Sp1 and Sp3."
Castoldi M. , Chu M.-L.
Biochem. J.362:41-50(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26
8.

"Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain."
Argraves W.S. , Dickerson K. , Burgess W.H. , Ruoslahti E.
Cell58:623-629(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-44
9.

"Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin."
Balbona K. , Tran H. , Godyna S. , Ingham K.C. , Strickland D.K. , Argraves W.S.
J. Biol. Chem.267:20120-20125(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SELF-ASSOCIATION;INTERACTION WITH FN1
10.

"The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study."
Roark E.F. , Keene D.R. , Haudenschild C.C. , Godyna S. , Little C.D. , Argraves W.S.
J. Histochem. Cytochem.43:401-411(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE FUNCTION
11.

"The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis."
Tran H. , Tanaka A. , Litvinovich S.V. , Medved L.V. , Haudenschild C.C. , Argraves W.S.
J. Biol. Chem.270:19458-19464(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGB
12.

"The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo."
Miosge N. , Gotz W. , Sasaki T. , Chu M.-L. , Timpl R. , Herken R.
Histochem. J.28:109-116(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
13.

"Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells."
Clinton G.M. , Rougeot C. , Derancourt J. , Roger P. , Defrenne A. , Godyna S. , Argraves W.S. , Rochefort H.
Proc. Natl. Acad. Sci. U.S.A.93:316-320(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
14.

"The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains."
Tran H. , VanDusen W.J. , Argraves W.S.
J. Biol. Chem.272:22600-22606(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CALCIUM-BINDING;SELF-ASSOCIATION;FN1-BINDING SITES
15.

"Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines."
Qing J. , Maher V.M. , Tran H. , Argraves W.S. , Dunstan R.W. , McCormick J.J.
Oncogene15:2159-2168(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN TUMOR FORMATION AND INVASION
16.

"Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors."
Roger P. , Pujol P. , Lucas A. , Baldet P. , Rochefort H.
Am. J. Pathol.153:1579-1588(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
17.

"Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin."
Hayashido Y. , Lucas A. , Rougeot C. , Godyna S. , Argraves W.S. , Rochefort H.
Int. J. Cancer75:654-658(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN TUMOR FORMATION AND INVASION
18.

"The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling."
Perbal B. , Martinerie C. , Sainson R. , Werner M. , He B. , Roizman B.
Proc. Natl. Acad. Sci. U.S.A.96:869-874(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOV
19.

"Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility."
Twal W.O. , Czirok A. , Hegedus B. , Knaak C. , Chintalapudi M.R. , Okagawa H. , Sugi Y. , Argraves W.S.
J. Cell Sci.114:4587-4598(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN CELL ADHESION AND MOTILITY
20.

"Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function."
Ohsawa I. , Takamura C. , Kohsaka S.
J. Neurochem.76:1411-1420(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APP
21.

"Interaction of oncogenic papillomavirus E6 proteins with fibulin-1."
Du M. , Fan X. , Hong E. , Chen J.J.
Biochem. Biophys. Res. Commun.296:962-969(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIGH-RISK HUMAN PAPILLOMAVIRUSES E6 PROTEIN;INHIBITION OF E6-MEDIATED TRANSFORMATION
22.

"The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly."
Debeer P. , Schoenmakers E.F.P.M. , Twal W.O. , Argraves W.S. , De Smet L. , Fryns J.-P. , Van De Ven W.J.M.
J. Med. Genet.39:98-104(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION
23.

"Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells."
Moll F. , Katsaros D. , Lazennec G. , Hellio N. , Roger P. , Giacalone P.-L. , Chalbos D. , Maudelonde T. , Rochefort H. , Pujol P.
Oncogene21:1097-1107(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
24.

"Elevated expression and altered processing of fibulin-1 protein in human breast cancer."
Greene L.M. , Twal W.O. , Duffy M.J. , McDermott E.W. , Hill A.D. , O'Higgins N.J. , McCann A.H. , Dervan P.A. , Argraves W.S. , Gallagher W.M.
Br. J. Cancer88:871-878(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH BREAST CANCER
25.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-98

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