Fbln1 ELISA Kit for Mouse(Mus musculus) | EIAab.comFbln1 ELISA Kit for Mouse(Mus musculus)

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Fbln1 (Gene name),

Fibulin-1 (Protein name ), FBLN1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fbln1;

Protein name:

Fibulin-1(FIBL-1);

Alternative:

Basement-membrane protein 90(BM-90);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LMA2, NID, ACAN, CSPG2 and type IV collagen. Interacts also with papillomavirus E6 proteins. Binding analysis demonstrated for isoform C a 100-fold stronger binding to the basement membrane protein NID than for isoform D. Interacts with FBLN7.

Function:

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

705

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

705:

SEYWF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q08879

UniGene:

Mm.297992

Pfam:

PF01821

String:

Q08879

KEGG:

mmu:14114

Uniprot:

Q08879

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ELISA Kit for Mouse FIBL-1

Cat.:

E0136m

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Packing:

96T

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ELISA Kit for Mouse FIBL-1

Cat.:

E0136h

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96T

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ELISA Kit for Mouse FIBL-1

Cat.:

E0136c

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Packing:

96T

CLIA Kit for Mouse FIBL-1

Cat.:

U0136h

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96T

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CLIA Kit for Mouse FIBL-1

Cat.:

U0136c

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MSDS:

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Packing:

96T

CLIA Kit for Mouse FIBL-1

Cat.:

U0136m

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Packing:

96T

Polyclonal Antibody for Mouse FIBL-1

Cat.:

P0136Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse FIBL-1

Cat.:

P0136Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse FIBL-1

Protein for Mouse FIBL-1

Cat.:

R0136h

Price:

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands."
Pan T.-C. , Kluge M. , Zhang R.Z. , Mayer U. , Timpl R. , Chu M.-L.
Eur. J. Biochem.215:733-740(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS C AND D);LIGANDS INTERACTION
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C)
strain: C57BL/6J.
tissue: Head.
tissue: Urinary bladder.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C)
tissue: Mammary tumor.
4.

"Structural and functional characterization of the human and mouse fibulin-1 gene promoters: role of Sp1 and Sp3."
Castoldi M. , Chu M.-L.
Biochem. J.362:41-50(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26
5.

"Characterization of a novel calcium-binding 90-kDa glycoprotein (BM-90) shared by basement membranes and serum."
Kluge M. , Mann K. , Dziadek M. , Timpl R.
Eur. J. Biochem.193:651-659(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-53; 110-117; 231-243; 339-387; 434-439; 469-476; 553-563 AND 574-581
6.

"Structural characterization of two variants of fibulin-1 that differ in nidogen affinity."
Sasaki T. , Kostka G. , Goehring W. , Wiedemann H. , Mann K. , Chu M.-L. , Timpl R.
J. Mol. Biol.245:241-250(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF NID AFFINITY
7.

"Fibulin-1 and fibulin-2 expression during organogenesis in the developing mouse embryo."
Zhang H.-Y. , Timpl R. , Sasaki T. , Chu M.-L. , Ekblom P.
Dev. Dyn.205:348-364(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
8.

"Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules."
Adam S. , Goehring W. , Wiedemann H. , Chu M.-L. , Timpl R. , Kostka G.
J. Mol. Biol.272:226-236(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NID-BINDING SITE
strain: 129/Sv.
9.

"Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins."
Talts J.F. , Andac Z. , Goehring W. , Brancaccio A. , Timpl R.
EMBO J.18:863-870(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LAMA2
10.

"Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican."
Aspberg A. , Adam S. , Kostka G. , Timpl R. , Heinegaard D.
J. Biol. Chem.274:20444-20449(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACAN AND CSPG2
11.

"Recombinant domains of mouse nidogen-1 and their binding to basement membrane proteins and monoclonal antibodies."
Ries A. , Goehring W. , Fox J.W. , Timpl R. , Sasaki T.
Eur. J. Biochem.268:5119-5128(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NID
12.

"Glucocorticoids down-regulate the extracellular matrix proteins fibronectin, fibulin-1 and fibulin-2 in bone marrow stroma."
Gu Y.-C. , Talts J.F. , Gullberg D. , Timpl R. , Ekblom M.
Eur. J. Haematol.67:176-184(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOWN-REGULATION BY GLUCOCORTICOIDS
13.

"Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function."
Ohsawa I. , Takamura C. , Kohsaka S.
J. Neurochem.76:1411-1420(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
14.

"Interaction of oncogenic papillomavirus E6 proteins with fibulin-1."
Du M. , Fan X. , Hong E. , Chen J.J.
Biochem. Biophys. Res. Commun.296:962-969(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH E6;INHIBITION OF E6-MEDIATED TRANSFORMATION
15.

"The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly."
Debeer P. , Schoenmakers E.F.P.M. , Twal W.O. , Argraves W.S. , De Smet L. , Fryns J.-P. , Van De Ven W.J.M.
J. Med. Genet.39:98-104(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
16.

"TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding."
de Vega S. , Iwamoto T. , Nakamura T. , Hozumi K. , McKnight D.A. , Fisher L.W. , Fukumoto S. , Yamada Y.
J. Biol. Chem.282:30878-30888(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBLN7

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