Fibrillin-1 (Protein name
), FBN1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Related Databases
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Gene name:
FBN1(FBN);
Protein name:
Fibrillin-1;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with COL16A1. Interacts with integrin alpha-V/beta-3.
Function:
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
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Precision
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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤3.9%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤7.7%
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Recovery
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Recovery was determined by spiking various levels of ACE into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
99
91-103
Plasma
98
93-106
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Linearity
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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
92-105%
90-101%
95-105%
92-109%
EDTA plasma(n=5)
89-95%
93105%
89-94%
90-106%
heparin plasma(n=5)
93-104%
94-110%
101-111%
91-110%
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MFS SER-2663
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT TYR-472
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT TYR-472
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT TYR-472
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Cited for: NUCLEOTIDE SEQUENCE [MRNA];NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-55;VARIANT TYR-472
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Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-448; ASN-1067; ASN-1484 AND ASN-1581
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Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 1486-1647 IN COMPLEX WITH CALCIUM IONS;FUNCTION;INTERACTION WITH INTEGRIN ALPHA-V/BETA-3;DISULFIDE BONDS
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Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 807-951 IN COMPLEX WITH CALCIUM;DISULFIDE BONDS
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Cited for: VARIANTS MFS SER-1249; ARG-1663; SER-2221 AND SER-2307
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Cited for: VARIANTS MFS ARG-862; TYR-1117; PRO-1137 AND PHE-1589;VARIANT ALA-1148
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Cited for: VARIANTS MFS GLY-217; ASN-1023; ARG-1074; TYR-1242; ARG-1513; GLU-2127; TRP-2151; LYS-2447 AND ARG-2511
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Cited for: VARIANTS MFS TYR-129; PHE-166; CYS-746; ARG-926; ARG-1013; LYS-1073; SER-1382 AND ARG-1928
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Cited for: VARIANTS MFS ARG-1053; GLY-1072; LYS-1073 AND GLY-1117
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Cited for: VARIANTS MFS THR-705; TYR-711; GLY-1055 AND TYR-1153
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Cited for: VARIANTS MFS PHE-504; TYR-1129; CYS-1261; SER-1833 AND TYR-2142
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Cited for: VARIANTS MFS CYS-114; ARG-890; GLY-1200; TYR-1835; ARG-2111; CYS-2474 AND GLY-2652;VARIANT ECTOL1 CYS-240
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Cited for: CHARACTERIZATION OF VARIANTS MFS CYS-627; GLY-750 AND ARG-926
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Cited for: VARIANTS SSKS SER-1564; CYS-1570; GLY-1577 AND ASP-1594