Gene name:
MS4A2 (APY;FCER1B;IGER) ;
Protein name:
High affinity immunoglobulin epsilon receptor subunit beta (FcERI) ;
Alternative:
IgE Fc receptor subunit beta ;Fc epsilon receptor I beta-chain ;Membrane-spanning 4-domains subfamily A member 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR and FES/FPS.
Function:
High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MDTESNRRAN | LALPQEPSSV | PAFEVLEISP | QEVSSGRLLK | SASSPPLHTW |
100:
LTVLKKEQEF | LGVTQILTAM | ICLCFGTVVC | SVLDISHIEG | DIFSSFKAGY |
150:
PFWGAIFFSI | SGMLSIISER | RNATYLVRGS | LGANTASSIA | GGTGITILII |
200:
NLKKSLAYIH | IHSCQKFFET | KCFMASFSTE | IVVMMLFLTI | LGLGSAVSLT |
244:
ICGAGEELKG | NKVPEDRVYE | ELNIYSATYS | ELEDPGEMSP | PIDL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Human FcERI
ELISA Kit for Human FcERI
ELISA Kit for Human FcERI
Polyclonal Antibody for Human FcERI
Polyclonal Antibody for Human FcERI
Polyclonal Antibody for Human FcERI
Monoclonal Antibody for Human FcERI
Monoclonal Antibody for Human FcERI
Monoclonal Antibody for Human FcERI
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLY-237
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLY-237
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM