FCGR2A ELISA Kit for Human(Homo sapiens) | EIAab.comFCGR2A ELISA Kit for Human(Homo sapiens)

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FCGR2A (Gene name),

Low affinity immunoglobulin gamma Fc region receptor II-a (Protein name ), FCG2A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FCGR2A(CD32;FCG2;FCGR2A1;IGFR2);

Protein name:

Low affinity immunoglobulin gamma Fc region receptor II-a(IgG Fc receptor II-a);

Alternative:

Fc-gamma RII-a(Fc-gamma-RIIa;FcRII-a);CDw32;

CD:

CD32;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR.

Function:

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

317

Sequence:

50:

100:

150:

200:

250:

300:

317:

KNIYLTLPPN | DHVNSNN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P12318

String:

P12318

STRING:

9606.ENSP00000271450

KEGG:

hsa:2212

UniGene:

Hs.352642

MIM:

146790

Uniprot:

P12318

FOR

ELISA Kit for Human IgG Fc receptor II-a

Cat.:

E1579h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human IgG Fc receptor II-a

Cat.:

U1579h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human IgG Fc receptor II-a

Cat.:

P1579Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IgG Fc receptor II-a

Protein for Human IgG Fc receptor II-a

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)."
Stuart S.G. , Trounstine M.L. , Vaux D.J.T. , Koch T. , Martens C.L. , Moore K.W.
J. Exp. Med.166:1668-1684(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-167
2.

"Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes."
Brooks D.G. , Qiu W.Q. , Luster A.D. , Ravetch J.V.
J. Exp. Med.170:1369-1385(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-167
3.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS ARG-167 AND VAL-218
tissue: Lung.
tissue: Testis.
5.

"Molecular cloning of a human immunoglobulin G Fc receptor."
Hibbs M.L. , Bonadonna L. , Scott B.M. , McKenzie I.F.C. , Hogarth P.M.
Proc. Natl. Acad. Sci. U.S.A.85:2240-2244(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-317 (ISOFORM 1);VARIANT ARG-167
6.

"Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning."
Stengelin S. , Stamenkovic I. , Seed B.
EMBO J.7:1053-1059(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-317 (ISOFORM 1);VARIANT ARG-167
7.

"Identification of multiple isoforms of the low-affinity human IgG Fc receptor."
Seki T.
Immunogenetics30:5-12(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-317 (ISOFORM 1)
8.

"Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG."
Powell M.S. , Barton P.A. , Emmanouilidis D. , Wines B.D. , Neumann G.M. , Peitersz G.A. , Maxwell K.F. , Garrett T.P. , Hogarth P.M.
Immunol. Lett.68:17-23(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;GLYCOSYLATION AT ASN-97 AND ASN-178;CRYSTALLIZATION
9.

"Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils."
Hamada F. , Aoki M. , Akiyama T. , Toyoshima K.
Proc. Natl. Acad. Sci. U.S.A.90:6305-6309(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGR
10.

"Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells."
Ghazizadeh S. , Bolen J.B. , Fleit H.B.
J. Biol. Chem.269:8878-8884(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCK;PHOSPHORYLATION
11.

"In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."
Bewarder N. , Weinrich V. , Budde P. , Hartmann D. , Flaswinkel H. , Reth M. , Frey J.
Mol. Cell. Biol.16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-288 AND TYR-304
12.

"SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling."
Pengal R.A. , Ganesan L.P. , Fang H. , Marsh C.B. , Anderson C.L. , Tridandapani S.
J. Biol. Chem.278:22657-22663(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INPPL1
13.

"Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa."
Maxwell K.F. , Powell M.S. , Hulett M.D. , Barton P.A. , McKenzie I.F. , Garrett T.P. , Hogarth P.M.
Nat. Struct. Biol.6:437-442(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 37-207
14.

"Molecular basis for immune complex recognition: a comparison of Fc-receptor structures."
Sondermann P. , Kaiser J. , Jacob U.
J. Mol. Biol.309:737-749(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 37-208;DISULFIDE BONDS
15.

"Structural recognition and functional activation of FcgammaR by innate pentraxins."
Lu J. , Marnell L.L. , Marjon K.D. , Mold C. , Du Clos T.W. , Sun P.D.
Nature456:989-992(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 37-207 IN COMPLEX WITH APCS;SUBCELLULAR LOCATION;FUNCTION;DISULFIDE BONDS
16.

"Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans."
Salmon J.E. , Millard S. , Schachter L.A. , Arnett F.C. , Ginzler E.M. , Gourley M.F. , Ramsey-Goldman R. , Peterson M.G.E. , Kimberly R.P.
J. Clin. Invest.97:1348-1354(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-167

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