FCGR3A ELISA Kit for Human(Homo sapiens) | EIAab.comFCGR3A ELISA Kit for Human(Homo sapiens)

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FCGR3A (Gene name),

Low affinity immunoglobulin gamma Fc region receptor III-A (Protein name ), FCG3A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FCGR3A(CD16A;FCG3;FCGR3;IGFR3);

Protein name:

Low affinity immunoglobulin gamma Fc region receptor III-A;

Alternative:

Fc-gamma RIII-alpha(Fc-gamma RIII;Fc-gamma RIIIa;FcRIII;FcRIIIa);CD16a antigen;IgG Fc receptor III-2;FcR-10;

CD:

CD16a;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1.

Function:

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Secreted Exists also as a soluble receptor.

Protein Attributes:

Sequence length:

254

Sequence:

50:

100:

150:

200:

250:

254:

PQDK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P08637

STRING:

9606.ENSP00000356946

MIM:

146740

SMR:

P08637

KEGG:

hsa:2214

UniGene:

Hs.372679

Uniprot:

P08637

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ELISA Kit for Human Low affinity immunoglobulin gamma Fc region receptor III-A

Cat.:

E1580h

Price:

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human Low affinity immunoglobulin gamma Fc region receptor III-A

Cat.:

U1580h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Low affinity immunoglobulin gamma Fc region receptor III-A

Cat.:

P1580Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Low affinity immunoglobulin gamma Fc region receptor III-A

Protein for Human Low affinity immunoglobulin gamma Fc region receptor III-A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions."
Ravetch J.V. , Perussia B.
J. Exp. Med.170:481-497(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"IgG Fc receptor III homologues in nonhuman primate species: genetic characterization and ligand interactions."
Rogers K.A. , Scinicariello F. , Attanasio R.
J. Immunol.177:3848-3856(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Blood.
3.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-176
tissue: Synovium.
4.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-176
tissue: Lung.
6.

"The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions."
Gessner J.E. , Grussenmeyer T. , Kolanus W. , Schmidt R.E.
J. Biol. Chem.270:1350-1361(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39
tissue: Placenta.
7.

"Human glomerular mesangial cells express CD16 and may be stimulated via this receptor."
Morcos M. , Hansch G.M. , Schonermark M. , Ellwanger S. , Harle M. , Heckl-Ostreicher B.
Kidney Int.46:1627-1634(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-254;VARIANT VAL-176
8.

"A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms."
Scallon B.J. , Scigliano E. , Freedman V.H. , Miedel M.C. , Pan Y.C. , Unkeless J.C. , Kochan J.P.
Proc. Natl. Acad. Sci. U.S.A.86:5079-5083(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-254
tissue: Lung.
9.

"Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans."
Mizushima T. , Yagi H. , Takemoto E. , Shibata-Koyama M. , Isoda Y. , Iida S. , Masuda K. , Satoh M. , Kato K.
Genes Cells16:1071-1080(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 21-193 IN COMPLEX WITH IGHG1;FUNCTION;DISULFIDE BONDS;GLYCOSYLATION AT ASN-63 AND ASN-180
10.

"Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose."
Ferrara C. , Grau S. , Jager C. , Sondermann P. , Brunker P. , Waldhauer I. , Hennig M. , Ruf A. , Rufer A.C. , Stihle M. , Umana P. , Benz J.
Proc. Natl. Acad. Sci. U.S.A.108:12669-12674(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 19-208 IN COMPLEX WITH IGHG1;FUNCTION;DISULFIDE BONDS;GLYCOSYLATION AT ASN-63 AND ASN-180
11.

"A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa."
de Haas M. , Koene H.R. , Kleijer M. , de Vries E. , Simsek S. , van Tol M.J.D. , Roos D. , von dem Borne A.E.G.K.
J. Immunol.156:2948-2955(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IMD20 HIS-66;VARIANT ARG-66
12.

"Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype."
Koene H.R. , Kleijer M. , Algra J. , Roos D. , von dem Borne A.E.G.K. , de Haas M.
Blood90:1109-1114(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-176
13.

"A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease."
Wu J. , Edberg J.C. , Redecha P.B. , Bansal V. , Guyre P.M. , Coleman K. , Salmon J.E. , Kimberly R.P.
J. Clin. Invest.100:1059-1070(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-176
14.

"Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections."
de Vries E. , Koene H.R. , Vossen J.M. , Gratama J.W. , von dem Borne A.E. , Waaijer J.L. , Haraldsson A. , de Haas M. , van Tol M.J.
Blood88:3022-3027(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RP VARIANT IMD20 HIS-66
15.

"Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II)."
Jawahar S. , Moody C. , Chan M. , Finberg R. , Geha R. , Chatila T.
Clin. Exp. Immunol.103:408-413(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RP VARIANT IMD20 HIS-66
16.

"Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity."
Grier J.T. , Forbes L.R. , Monaco-Shawver L. , Oshinsky J. , Atkinson T.P. , Moody C. , Pandey R. , Campbell K.S. , Orange J.S.
J. Clin. Invest.122:3769-3780(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RP VARIANT IMD20 HIS-66

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