Gene name:
FCGR3B(CD16B;FCG3;FCGR3;IGFR3);
Protein name:
Low affinity immunoglobulin gamma Fc region receptor III-B;
Alternative:
FcR-10;Fc-gamma RIII-beta(Fc-gamma RIII;Fc-gamma RIIIb;FcRIII;FcRIIIb);IgG Fc receptor III-1;
CD:
CD16b;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Monomer. Interacts with INPP5D/SHIP1.
Function:
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Subcellular Location:
Cell membrane
Lipid-anchor
GPI-anchor
Secreted
Secreted after cleavage.
Protein Attributes:
50:
MWQLLLPTAL | LLLVSAGMRT | EDLPKAVVFL | EPQWYSVLEK | DSVTLKCQGA |
100:
YSPEDNSTQW | FHNESLISSQ | ASSYFIDAAT | VNDSGEYRCQ | TNLSTLSDPV |
150:
QLEVHIGWLL | LQAPRWVFKE | EDPIHLRCHS | WKNTALHKVT | YLQNGKDRKY |
200:
FHHNSDFHIP | KATLKDSGSY | FCRGLVGSKN | VSSETVNITI | TQGLAVSTIS |
233:
SFSPPGYQVS | FCLVMVLLFA | VDTGLYFSVK | TNI
Vaild Sequence:
Related Databases
Uniprot: