FCGR1A ELISA Kit for Human(Homo sapiens) | EIAab.comFCGR1A ELISA Kit for Human(Homo sapiens)

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FCGR1A (Gene name),

High affinity immunoglobulin gamma Fc receptor I (Protein name ), FCGR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FCGR1A(FCG1;FCGR1;IGFR1);

Protein name:

High affinity immunoglobulin gamma Fc receptor I(IgG Fc receptor I);

Alternative:

Fc-gamma RIA(FcgammaRIa);Fc-gamma RI(FcRI);

CD:

CD64;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL.

Function:

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Stabilized at the cell membrane through interaction with FCER1G.

Protein Attributes:

Sequence length:

374

Sequence:

50:

100:

150:

200:

250:

300:

350:

374:

LKCQEQKEEQ | LQEGVHRKEP | QGAT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:2209

UniGene:

Hs.77424

String:

P12314

MIM:

146760

Pfam:

PF00047

STRING:

9606.ENSP00000358165

SMR:

P12314

Uniprot:

P12314

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ELISA Kit for Human IgG Fc receptor I

Cat.:

E1578h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human IgG Fc receptor I

Cat.:

U1578h

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Manual:

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Packing:

96T

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Polyclonal Antibody for Human IgG Fc receptor I

Cat.:

P1578Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IgG Fc receptor I

Protein for Human IgG Fc receptor I

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI)."
Allen J.M. , Seed B.
Nucleic Acids Res.16:11824-11824(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
2.

"Isolation and expression of functional high-affinity Fc receptor complementary DNAs."
Allen J.M. , Seed B.
Science243:378-381(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Novel Fc gamma receptor I family gene products in human mononuclear cells."
Porges A.J. , Redecha P.B. , Doebele R. , Pan L.C. , Salmon J.E. , Kimberly R.P.
J. Clin. Invest.90:2102-2109(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Blood.
4.

"Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure."
Benech P.D. , Sastry K.N. , Iyer R.R. , Eichbaum Q.G. , Raveh D.P. , Ezekowitz R.A.
J. Exp. Med.176:1115-1123(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Blood.
5.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 16-30
7.

"Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products."
Ernst L.K. , van de Winkel J.G. , Chiu I.M. , Anderson C.L.
J. Biol. Chem.267:15692-15700(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
8.

"Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn."
Wang A.V. , Scholl P.R. , Geha R.S.
J. Exp. Med.180:1165-1170(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCK AND LYN
9.

"FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo."
van Vugt M.J. , Heijnen I.A.F.M. , Capel P.J.A. , Park S.Y. , Ra C. , Saito T. , Verbeek J.S. , van de Winkel J.G.J.
Blood87:3593-3599(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FCER1G;SUBCELLULAR LOCATION
10.

"Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts."
Ernst L.K. , Duchemin A.-M. , Miller K.L. , Anderson C.L.
Mol. Immunol.35:943-954(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ALTERNATIVE SPLICING;GLYCOSYLATION
11.

"The FcgammaRIa (CD64) ligand binding chain triggers major histocompatibility complex class II antigen presentation independently of its associated FcR gamma-chain."
van Vugt M.J. , Kleijmeer M.J. , Keler T. , Zeelenberg I. , van Dijk M.A. , Leusen J.H.W. , Geuze H.J. , van de Winkel J.G.J.
Blood94:808-817(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complex."
Edberg J.C. , Yee A.M. , Rakshit D.S. , Chang D.J. , Gokhale J.A. , Indik Z.K. , Schreiber A.D. , Kimberly R.P.
J. Biol. Chem.274:30328-30333(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FCER1G
13.

"The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells."
Tridandapani S. , Lyden T.W. , Smith J.L. , Carter J.E. , Coggeshall K.M. , Anderson C.L.
J. Biol. Chem.275:20480-20487(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LAT
14.

"Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis."
Kim M.-K. , Huang Z.-Y. , Hwang P.-H. , Jones B.A. , Sato N. , Hunter S. , Kim-Han T.-H. , Worth R.G. , Indik Z.K. , Schreiber A.D.
Blood101:4479-4484(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASN-306;SUBCELLULAR LOCATION
15.

"Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity."
Beekman J.M. , Bakema J.E. , van de Winkel J.G.J. , Leusen J.H.W.
Proc. Natl. Acad. Sci. U.S.A.101:10392-10397(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPL
16.

"Filamin A stabilizes FcgammaRI surface expression and prevents its lysosomal routing."
Beekman J.M. , van der Poel C.E. , van der Linden J.A. , van den Berg D.L.C. , van den Berghe P.V.E. , van de Winkel J.G.J. , Leusen J.H.W.
J. Immunol.180:3938-3945(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLNA
17.

"Protein 4.1G binds to a unique motif within the FcgammaRI cytoplasmic tail."
Beekman J.M. , Bakema J.E. , van der Poel C.E. , van der Linden J.A. , van de Winkel J.G.J. , Leusen J.H.W.
Mol. Immunol.45:2069-2075(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPB41L2
18.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78
tissue: Liver.
19.

"Crystal structure of Fcgamma receptor I and its implication in high affinity gamma-immunoglobulin binding."
Lu J. , Ellsworth J.L. , Hamacher N. , Oak S.W. , Sun P.D.
J. Biol. Chem.286:40608-40613(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 21-282;FUNCTION;DISULFIDE BONDS;GLYCOSYLATION AT ASN-59; ASN-78; ASN-152; ASN-159; ASN-163 AND ASN-195

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